ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 78/401 145/7206 6.221316993e-61 ko03030 DNA replication 19/401 38/7206 1.27809094216e-14 ko03460 Fanconi anemia pathway 21/401 51/7206 6.59537324738e-14 ko03022 Basal transcription factors 19/401 44/7206 3.73337122959e-13 ko03420 Nucleotide excision repair 19/401 46/7206 9.92525218733e-13 ko04110 Cell cycle 33/401 145/7206 1.65556625148e-12 ko04111 Cell cycle - yeast 24/401 90/7206 5.77826132812e-11 ko03013 RNA transport 32/401 166/7206 3.74687946017e-10 ko03430 Mismatch repair 11/401 22/7206 5.60362183696e-09 ko03015 mRNA surveillance pathway 21/401 93/7206 2.41678880517e-08 ko04113 Meiosis - yeast 18/401 70/7206 2.85590432608e-08 ko03410 Base excision repair 13/401 38/7206 6.12253348573e-08 ko03018 RNA degradation 17/401 84/7206 2.72564225145e-06 ko04144 Endocytosis 3/401 342/7206 5.48551787424e-06 ko00240 Pyrimidine metabolism 19/401 110/7206 8.41855045165e-06 ko03440 Homologous recombination 11/401 41/7206 9.58072755828e-06 ko03008 Ribosome biogenesis in eukaryotes 15/401 79/7206 2.3686458587e-05 ko04120 Ubiquitin mediated proteolysis 20/401 138/7206 6.94628635578e-05 ko04921 Oxytocin signaling pathway 1/401 209/7206 0.000159556744524 ko04072 Phospholipase D signaling pathway 1/401 197/7206 0.000225067498298 ko04022 cGMP-PKG signaling pathway 2/401 216/7206 0.000720927824079 ko04024 cAMP signaling pathway 4/401 279/7206 0.000731823754267 ko03020 RNA polymerase 7/401 29/7206 0.000840792751049 ko04151 PI3K-Akt signaling pathway 8/401 390/7206 0.000871465161486 ko04145 Phagosome 1/401 162/7206 0.00152907526684 ko04060 Cytokine-cytokine receptor interaction 2/401 191/7206 0.00209152744088 ko04270 Vascular smooth muscle contraction 1/401 154/7206 0.00223493387346 ko04621 NOD-like receptor signaling pathway 1/401 157/7206 0.00226006958138 ko04725 Cholinergic synapse 1/401 160/7206 0.00236395335432 ko04014 Ras signaling pathway 5/401 279/7206 0.00298736804495 ko05152 Tuberculosis 2/401 187/7206 0.00305574140498 ko05166 HTLV-I infection 28/401 292/7206 0.00398495582686 ko05205 Proteoglycans in cancer 5/401 271/7206 0.00407758922467 ko04371 Apelin signaling pathway 2/401 177/7206 0.00427646562024 ko04261 Adrenergic signaling in cardiomyocytes 3/401 205/7206 0.0049375639598 ko04810 Regulation of actin cytoskeleton 5/401 264/7206 0.00560551519592 ko04713 Circadian entrainment 1/401 136/7206 0.00702002463854 ko04015 Rap1 signaling pathway 6/401 278/7206 0.00733828497575 ko03450 Non-homologous end-joining 4/401 15/7206 0.00789547301973 ko01200 Carbon metabolism 1/401 128/7206 0.0101163670697 ko03010 Ribosome 1/401 129/7206 0.0102123991646 ko05142 Chagas disease (American trypanosomiasis) 1/401 130/7206 0.0103434504 ko04915 Estrogen signaling pathway 1/401 131/7206 0.0105098418416 ko04010 MAPK signaling pathway 8/401 321/7206 0.0120087066087 ko00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 5/401 26/7206 0.0129758582876 ko04932 Non-alcoholic fatty liver disease (NAFLD) 3/401 182/7206 0.013378746681 ko04728 Dopaminergic synapse 3/401 185/7206 0.013566298703 ko04510 Focal adhesion 5/401 240/7206 0.0138842866415 ko04668 TNF signaling pathway 1/401 120/7206 0.0145887967532 ko04750 Inflammatory mediator regulation of TRP channels 1/401 122/7206 0.0148324434238 ko04660 T cell receptor signaling pathway 1/401 124/7206 0.0152714233774 ko04670 Leukocyte transendothelial migration 2/401 151/7206 0.0177433942108 ko04062 Chemokine signaling pathway 4/401 201/7206 0.0188004562213 ko04360 Axon guidance 5/401 233/7206 0.0188077055962 ko04911 Insulin secretion 1/401 117/7206 0.0221495673582 ko04068 FoxO signaling pathway 3/401 167/7206 0.0255995920628 ko04659 Th17 cell differentiation 1/401 106/7206 0.0305510598174 ko05203 Viral carcinogenesis 24/401 277/7206 0.0310586304461 ko05168 Herpes simplex infection 17/401 182/7206 0.0320436421101 ko05032 Morphine addiction 1/401 110/7206 0.0320608705038 ko04380 Osteoclast differentiation 2/401 134/7206 0.0344049880891 ko05231 Choline metabolism in cancer 2/401 134/7206 0.0344049880891 ko04933 AGE-RAGE signaling pathway in diabetic complications 2/401 135/7206 0.0346387822607 ko04071 Sphingolipid signaling pathway 3/401 162/7206 0.0355474088466 ko04611 Platelet activation 3/401 163/7206 0.0357997658472 ko03060 Protein export 4/401 23/7206 0.0360797457733 ko04650 Natural killer cell mediated cytotoxicity 1/401 97/7206 0.0437279371273 ko04658 Th1 and Th2 cell differentiation 1/401 96/7206 0.0437398804795 ko04064 NF-kappa B signaling pathway 1/401 96/7206 0.0437398804795 ko05132 Salmonella infection 1/401 98/7206 0.0438429069137 ko00564 Glycerophospholipid metabolism 1/401 99/7206 0.0440841885886 ko04620 Toll-like receptor signaling pathway 1/401 100/7206 0.0444512589867 ko05160 Hepatitis C 3/401 153/7206 0.0483570179983