ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 51/633 191/7206 1.4552099875e-13 ko04380 Osteoclast differentiation 37/633 134/7206 1.26378227834e-10 ko04621 NOD-like receptor signaling pathway 39/633 157/7206 1.21066152225e-09 ko05340 Primary immunodeficiency 14/633 30/7206 5.45198717115e-08 ko04630 Jak-STAT signaling pathway 32/633 132/7206 7.15121964558e-08 ko04064 NF-kappa B signaling pathway 26/633 96/7206 1.15267608209e-07 ko00120 Primary bile acid biosynthesis 11/633 20/7206 1.77557708855e-07 ko05164 Influenza A 36/633 167/7206 4.44124596909e-07 ko04620 Toll-like receptor signaling pathway 25/633 100/7206 1.05576687361e-06 ko05162 Measles 28/633 120/7206 1.0905430453e-06 ko04217 Necroptosis 36/633 178/7206 1.42623923843e-06 ko04650 Natural killer cell mediated cytotoxicity 24/633 97/7206 2.11738911137e-06 ko05145 Toxoplasmosis 28/633 126/7206 3.0679214797e-06 ko05321 Inflammatory bowel disease (IBD) 17/633 56/7206 3.341712547e-06 ko05140 Leishmaniasis 20/633 75/7206 4.370706297e-06 ko04610 Complement and coagulation cascades 20/633 79/7206 1.0306311668e-05 ko05150 Staphylococcus aureus infection 12/633 36/7206 3.30695724679e-05 ko03040 Spliceosome 1/633 145/7206 3.97522793726e-05 ko04390 Hippo signaling pathway 3/633 188/7206 6.38748756099e-05 ko03013 RNA transport 2/633 166/7206 6.84516929645e-05 ko04612 Antigen processing and presentation 18/633 77/7206 8.87485419263e-05 ko04640 Hematopoietic cell lineage 16/633 64/7206 9.25936157259e-05 ko05152 Tuberculosis 33/633 187/7206 0.000104962170865 ko04668 TNF signaling pathway 24/633 120/7206 0.000109845017955 ko05168 Herpes simplex infection 32/633 182/7206 0.000148192479132 ko04660 T cell receptor signaling pathway 24/633 124/7206 0.00017263472002 ko03010 Ribosome 1/633 129/7206 0.000203170674789 ko04146 Peroxisome 19/633 89/7206 0.000207113770113 ko04110 Cell cycle 2/633 145/7206 0.00029203296246 ko00360 Phenylalanine metabolism 7/633 17/7206 0.000346698041516 ko04659 Th17 cell differentiation 21/633 106/7206 0.000348857020413 ko05144 Malaria 12/633 45/7206 0.000363643264953 ko00350 Tyrosine metabolism 10/633 33/7206 0.00036516694615 ko05167 Kaposi's sarcoma-associated herpesvirus infection 32/633 191/7206 0.000369563325434 ko05034 Alcoholism 7/633 238/7206 0.000416417292996 ko05133 Pertussis 18/633 87/7206 0.000453392509174 ko04137 Mitophagy - animal 17/633 82/7206 0.000631970219569 ko04210 Apoptosis 30/633 180/7206 0.000692380520382 ko05330 Allograft rejection 8/633 24/7206 0.000699558487519 ko00051 Fructose and mannose metabolism 11/633 42/7206 0.000751110616398 ko04622 RIG-I-like receptor signaling pathway 14/633 62/7206 0.000770210631701 ko04672 Intestinal immune network for IgA production 10/633 37/7206 0.000995859252898 ko04658 Th1 and Th2 cell differentiation 18/633 96/7206 0.00166316578545 ko04662 B cell receptor signaling pathway 17/633 88/7206 0.0017449040875 ko05323 Rheumatoid arthritis 17/633 89/7206 0.00191953079828 ko04623 Cytosolic DNA-sensing pathway 10/633 41/7206 0.00232544001737 ko05224 Breast cancer 5/633 174/7206 0.00263508238537 ko05320 Autoimmune thyroid disease 8/633 29/7206 0.00275398594172 ko03015 mRNA surveillance pathway 1/633 93/7206 0.00288261982125 ko05332 Graft-versus-host disease 6/633 18/7206 0.00331921202993 ko00071 Fatty acid degradation 10/633 45/7206 0.00480697952237 ko04310 Wnt signaling pathway 6/633 181/7206 0.00499921836084 ko05161 Hepatitis B 26/633 173/7206 0.0060625320389 ko04062 Chemokine signaling pathway 29/633 201/7206 0.00740184657495 ko04068 FoxO signaling pathway 25/633 167/7206 0.00789010476764 ko00950 Isoquinoline alkaloid biosynthesis 4/633 10/7206 0.00805502284391 ko05160 Hepatitis C 23/633 153/7206 0.00905559413877 ko04723 Retrograde endocannabinoid signaling 6/633 175/7206 0.00940743316727 ko04080 Neuroactive ligand-receptor interaction 23/633 423/7206 0.0101061872568 ko00380 Tryptophan metabolism 10/633 50/7206 0.0103998387441 ko00362 Benzoate degradation 3/633 6/7206 0.0110230097874 ko04611 Platelet activation 24/633 163/7206 0.0110269443781 ko04360 Axon guidance 10/633 233/7206 0.0127934815395 ko05310 Asthma 5/633 17/7206 0.0130510271487 ko04972 Pancreatic secretion 3/633 111/7206 0.0171205532643 ko00592 alpha-Linolenic acid metabolism 5/633 19/7206 0.0211860168912 ko05142 Chagas disease (American trypanosomiasis) 19/633 130/7206 0.0268555223731 ko00983 Drug metabolism - other enzymes 8/633 42/7206 0.0275613283949 ko05217 Basal cell carcinoma 1/633 68/7206 0.0285289651294 ko05132 Salmonella infection 15/633 98/7206 0.0296354462794 ko05131 Shigellosis 13/633 82/7206 0.0301924200133 ko04350 TGF-beta signaling pathway 3/633 103/7206 0.0333276240228 ko05134 Legionellosis 12/633 74/7206 0.0354505820913 ko00982 Drug metabolism - cytochrome P450 7/633 37/7206 0.039429467292 ko05418 Fluid shear stress and atherosclerosis 23/633 173/7206 0.0406916856866 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/633 4/7206 0.0410099006008 ko00643 Styrene degradation 2/633 4/7206 0.0410099006008 ko04721 Synaptic vesicle cycle 2/633 80/7206 0.0449947733812 ko04932 Non-alcoholic fatty liver disease (NAFLD) 24/633 182/7206 0.0450782381204