ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko03040	Spliceosome	100/921	145/7206	1.02302635272e-56
ko05322	Systemic lupus erythematosus	74/921	151/7206	6.42524608776e-28
ko03013	RNA transport	78/921	166/7206	7.89712307582e-28
ko04110	Cell cycle	68/921	145/7206	2.65270753709e-24
ko03460	Fanconi anemia pathway	37/921	51/7206	9.96446410444e-23
ko03440	Homologous recombination	32/921	41/7206	1.76815868889e-21
ko03008	Ribosome biogenesis in eukaryotes	44/921	79/7206	7.32523492833e-20
ko04111	Cell cycle - yeast	47/921	90/7206	1.41930173761e-19
ko03030	DNA replication	29/921	38/7206	4.29947105533e-19
ko05034	Alcoholism	79/921	238/7206	7.76925603968e-17
ko05203	Viral carcinogenesis	83/921	277/7206	1.13538899963e-14
ko04020	Calcium signaling pathway	2/921	265/7206	1.42149262333e-13
ko03420	Nucleotide excision repair	27/921	46/7206	1.97115592532e-13
ko04113	Meiosis - yeast	34/921	70/7206	2.66295462229e-13
ko03430	Mismatch repair	18/921	22/7206	3.15481850103e-13
ko03022	Basal transcription factors	26/921	44/7206	4.45880099323e-13
ko03018	RNA degradation	37/921	84/7206	1.04987555215e-12
ko00240	Pyrimidine metabolism	43/921	110/7206	2.19946034687e-12
ko04144	Endocytosis	10/921	342/7206	1.2701871661e-10
ko03015	mRNA surveillance pathway	35/921	93/7206	8.60412918623e-10
ko04024	cAMP signaling pathway	7/921	279/7206	1.23973519896e-09
ko04060	Cytokine-cytokine receptor interaction	2/921	191/7206	2.07547957988e-09
ko03410	Base excision repair	20/921	38/7206	3.85721145003e-09
ko03020	RNA polymerase	17/921	29/7206	6.49728427574e-09
ko05010	Alzheimer's disease	4/921	202/7206	4.5077002214e-08
ko04723	Retrograde endocannabinoid signaling	3/921	175/7206	2.17667718261e-07
ko04270	Vascular smooth muscle contraction	2/921	154/7206	2.73723204222e-07
ko04022	cGMP-PKG signaling pathway	6/921	216/7206	3.95125332689e-07
ko04724	Glutamatergic synapse	2/921	152/7206	4.208075214e-07
ko04151	PI3K-Akt signaling pathway	20/921	390/7206	4.51733181173e-07
ko04932	Non-alcoholic fatty liver disease (NAFLD)	4/921	182/7206	4.56784126711e-07
ko04015	Rap1 signaling pathway	11/921	278/7206	5.33717229225e-07
ko04921	Oxytocin signaling pathway	6/921	209/7206	8.08062686104e-07
ko04261	Adrenergic signaling in cardiomyocytes	6/921	205/7206	1.1430728377e-06
ko04621	NOD-like receptor signaling pathway	3/921	157/7206	1.46464189313e-06
ko04510	Focal adhesion	9/921	240/7206	1.76218747219e-06
ko04713	Circadian entrainment	2/921	136/7206	3.0827786914e-06
ko04911	Insulin secretion	1/921	117/7206	3.84653071581e-06
ko05414	Dilated cardiomyopathy	1/921	112/7206	5.52819452088e-06
ko04725	Cholinergic synapse	4/921	160/7206	6.43873615294e-06
ko04120	Ubiquitin mediated proteolysis	37/921	138/7206	7.22155960606e-06
ko04810	Regulation of actin cytoskeleton	12/921	264/7206	7.92655739219e-06
ko00190	Oxidative phosphorylation	2/921	127/7206	1.03118514235e-05
ko04010	MAPK signaling pathway	17/921	321/7206	1.04685085918e-05
ko05012	Parkinson's disease	4/921	155/7206	1.38736088181e-05
ko04014	Ras signaling pathway	14/921	279/7206	1.48787480508e-05
ko04380	Osteoclast differentiation	3/921	134/7206	2.16428644513e-05
ko05410	Hypertrophic cardiomyopathy (HCM)	1/921	100/7206	2.84554111296e-05
ko04915	Estrogen signaling pathway	3/921	131/7206	3.15558765938e-05
ko04062	Chemokine signaling pathway	8/921	201/7206	3.57769927181e-05
ko04971	Gastric acid secretion	1/921	98/7206	4.42067075507e-05
ko04728	Dopaminergic synapse	7/921	185/7206	4.55259893235e-05
ko04514	Cell adhesion molecules (CAMs)	3/921	130/7206	4.75797444153e-05
ko04070	Phosphatidylinositol signaling system	2/921	112/7206	4.76014078516e-05
ko05145	Toxoplasmosis	3/921	126/7206	6.77500881475e-05
ko04727	GABAergic synapse	2/921	110/7206	7.06435003614e-05
ko04726	Serotonergic synapse	4/921	137/7206	8.50671528906e-05
ko04371	Apelin signaling pathway	7/921	177/7206	8.7814913948e-05
ko04611	Platelet activation	6/921	163/7206	0.000115330091742
ko04360	Axon guidance	12/921	233/7206	0.000131476134659
ko04072	Phospholipase D signaling pathway	9/921	197/7206	0.000132972757173
ko04668	TNF signaling pathway	3/921	120/7206	0.000144713019642
ko04114	Oocyte meiosis	34/921	139/7206	0.00015062723897
ko04920	Adipocytokine signaling pathway	1/921	89/7206	0.000152198222584
ko03450	Non-homologous end-joining	8/921	15/7206	0.000193915853183
ko04620	Toll-like receptor signaling pathway	2/921	100/7206	0.000224290952429
ko04924	Renin secretion	1/921	86/7206	0.000229645213892
ko03010	Ribosome	4/921	129/7206	0.000255739165254
ko03060	Protein export	10/921	23/7206	0.000262892338726
ko05142	Chagas disease (American trypanosomiasis)	4/921	130/7206	0.000264517846106
ko04976	Bile secretion	1/921	80/7206	0.000322775361718
ko04740	Olfactory transduction	1/921	80/7206	0.000322775361718
ko05152	Tuberculosis	9/921	187/7206	0.00034373203422
ko05032	Morphine addiction	3/921	110/7206	0.000435211974408
ko04972	Pancreatic secretion	3/921	111/7206	0.000448967634307
ko04912	GnRH signaling pathway	4/921	122/7206	0.000515240939347
ko04750	Inflammatory mediator regulation of TRP channels	4/921	122/7206	0.000515240939347
ko04530	Tight junction	13/921	228/7206	0.000554160404825
ko04925	Aldosterone synthesis and secretion	3/921	105/7206	0.000620207726026
ko04659	Th17 cell differentiation	3/921	106/7206	0.000620260872129
ko05031	Amphetamine addiction	2/921	91/7206	0.000712989593547
ko05140	Leishmaniasis	1/921	75/7206	0.000722800488808
ko04630	Jak-STAT signaling pathway	5/921	132/7206	0.000834571279117
ko00230	Purine metabolism	41/921	194/7206	0.00096643957719
ko05200	Pathways in cancer	40/921	492/7206	0.000973202225883
ko05168	Herpes simplex infection	39/921	182/7206	0.000987186368023
ko04146	Peroxisome	2/921	89/7206	0.00108258866353
ko00562	Inositol phosphate metabolism	2/921	89/7206	0.00108258866353
ko05030	Cocaine addiction	1/921	73/7206	0.00111901506295
ko04922	Glucagon signaling pathway	5/921	128/7206	0.00114716660601
ko04933	AGE-RAGE signaling pathway in diabetic complications	6/921	135/7206	0.00163435665918
ko04931	Insulin resistance	6/921	137/7206	0.00168057195901
ko04152	AMPK signaling pathway	8/921	161/7206	0.00169216640655
ko04658	Th1 and Th2 cell differentiation	3/921	96/7206	0.00183432465581
ko05169	Epstein-Barr virus infection	42/921	206/7206	0.00195734094672
ko04721	Synaptic vesicle cycle	2/921	80/7206	0.00219174044926
ko04666	Fc gamma R-mediated phagocytosis	5/921	122/7206	0.00227249076518
ko05231	Choline metabolism in cancer	6/921	134/7206	0.00233929032753
ko04670	Leukocyte transendothelial migration	8/921	151/7206	0.00300733797352
ko04540	Gap junction	6/921	128/7206	0.00310413976215
ko04923	Regulation of lipolysis in adipocytes	2/921	77/7206	0.00318212230546
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	2/921	79/7206	0.0032911002415
ko04512	ECM-receptor interaction	2/921	79/7206	0.0032911002415
ko00561	Glycerolipid metabolism	1/921	63/7206	0.00361236197459
ko04640	Hematopoietic cell lineage	1/921	64/7206	0.00377187811151
ko04218	Cellular senescence	36/921	177/7206	0.00409534705556
ko05167	Kaposi's sarcoma-associated herpesvirus infection	12/921	191/7206	0.00418358241696
ko05205	Proteoglycans in cancer	20/921	271/7206	0.00522542212903
ko04962	Vasopressin-regulated water reabsorption	1/921	58/7206	0.00523373216884
ko05133	Pertussis	3/921	87/7206	0.00536504378761
ko04662	B cell receptor signaling pathway	3/921	88/7206	0.00549369390859
ko05132	Salmonella infection	4/921	98/7206	0.00570360769851
ko00564	Glycerophospholipid metabolism	4/921	99/7206	0.0057562656739
ko04066	HIF-1 signaling pathway	6/921	123/7206	0.00590427121664
ko04660	T cell receptor signaling pathway	6/921	124/7206	0.00603310297554
ko04712	Circadian rhythm - plant	4/921	7/7206	0.00673870557384
ko05166	HTLV-I infection	53/921	292/7206	0.00708235690394
ko05418	Fluid shear stress and atherosclerosis	11/921	173/7206	0.00779057295098
ko01200	Carbon metabolism	7/921	128/7206	0.0104476162179
ko04930	Type II diabetes mellitus	1/921	54/7206	0.0119817873161
ko04115	p53 signaling pathway	17/921	74/7206	0.0133168258811
ko05130	Pathogenic Escherichia coli infection	3/921	77/7206	0.0151272133057
ko04720	Long-term potentiation	5/921	99/7206	0.0151580740424
ko04730	Long-term depression	3/921	78/7206	0.0154321706145
ko04914	Progesterone-mediated oocyte maturation	22/921	104/7206	0.0166828808487
ko04071	Sphingolipid signaling pathway	11/921	162/7206	0.0172026402636
ko04142	Lysosome	10/921	151/7206	0.0189323054309
ko04622	RIG-I-like receptor signaling pathway	2/921	62/7206	0.0201206321885
ko04650	Natural killer cell mediated cytotoxicity	5/921	97/7206	0.0207088006536
ko04916	Melanogenesis	9/921	142/7206	0.0212840614514
ko00010	Glycolysis / Gluconeogenesis	3/921	74/7206	0.0213406347546
ko05134	Legionellosis	3/921	74/7206	0.0213406347546
ko04918	Thyroid hormone synthesis	4/921	86/7206	0.0214917090505
ko00620	Pyruvate metabolism	1/921	46/7206	0.0250227573154
ko05164	Influenza A	12/921	167/7206	0.0256613289527
ko04068	FoxO signaling pathway	12/921	167/7206	0.0256613289527
ko05204	Chemical carcinogenesis	1/921	48/7206	0.0264810805716
ko00260	Glycine, serine and threonine metabolism	1/921	48/7206	0.0264810805716
ko05016	Huntington's disease	17/921	215/7206	0.0290101463011
ko05230	Central carbon metabolism in cancer	4/921	81/7206	0.0291516044768
ko05202	Transcriptional misregulation in cancer	34/921	188/7206	0.034696349328
ko00565	Ether lipid metabolism	1/921	42/7206	0.0366990081569
ko05160	Hepatitis C	11/921	153/7206	0.0367247842101
ko04910	Insulin signaling pathway	13/921	172/7206	0.0370644452991
ko05323	Rheumatoid arthritis	5/921	89/7206	0.037822490401