ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	185/1103	423/7206	8.99064899371e-48
ko04724	Glutamatergic synapse	89/1103	152/7206	3.45149653938e-35
ko05033	Nicotine addiction	47/1103	56/7206	3.91314062568e-30
ko05032	Morphine addiction	66/1103	110/7206	3.57560514392e-27
ko04727	GABAergic synapse	64/1103	110/7206	2.54761091336e-25
ko04713	Circadian entrainment	70/1103	136/7206	2.72680112504e-23
ko04725	Cholinergic synapse	75/1103	160/7206	1.12922135122e-21
ko04728	Dopaminergic synapse	82/1103	185/7206	1.23328381769e-21
ko04721	Synaptic vesicle cycle	49/1103	80/7206	5.19102964463e-21
ko04723	Retrograde endocannabinoid signaling	76/1103	175/7206	1.77796639014e-19
ko04024	cAMP signaling pathway	98/1103	279/7206	5.75532796458e-17
ko04744	Phototransduction	28/1103	36/7206	9.72253797859e-17
ko04020	Calcium signaling pathway	92/1103	265/7206	1.88162877839e-15
ko04911	Insulin secretion	53/1103	117/7206	7.25372403097e-15
ko04742	Taste transduction	35/1103	61/7206	3.88699735486e-14
ko04921	Oxytocin signaling pathway	75/1103	209/7206	1.03760540786e-13
ko04726	Serotonergic synapse	55/1103	137/7206	1.07350316163e-12
ko05031	Amphetamine addiction	40/1103	91/7206	4.96435039963e-11
ko04720	Long-term potentiation	42/1103	99/7206	6.55900296326e-11
ko04261	Adrenergic signaling in cardiomyocytes	68/1103	205/7206	8.82339879453e-11
ko04970	Salivary secretion	38/1103	95/7206	4.01983428641e-09
ko03040	Spliceosome	2/1103	145/7206	1.63778421741e-08
ko05203	Viral carcinogenesis	14/1103	277/7206	8.76336415587e-08
ko04925	Aldosterone synthesis and secretion	38/1103	105/7206	1.21152668972e-07
ko04740	Olfactory transduction	31/1103	80/7206	2.5611710383e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1103	74/7206	4.7072327686e-07
ko04971	Gastric acid secretion	35/1103	98/7206	5.29297571033e-07
ko05168	Herpes simplex infection	7/1103	182/7206	1.03091279063e-06
ko04060	Cytokine-cytokine receptor interaction	8/1103	191/7206	1.18666748471e-06
ko05030	Cocaine addiction	28/1103	73/7206	1.23900509569e-06
ko04621	NOD-like receptor signaling pathway	6/1103	157/7206	5.31634523226e-06
ko04966	Collecting duct acid secretion	14/1103	26/7206	5.64622156316e-06
ko04514	Cell adhesion molecules (CAMs)	40/1103	130/7206	6.45291743583e-06
ko04022	cGMP-PKG signaling pathway	58/1103	216/7206	8.25135854896e-06
ko03013	RNA transport	7/1103	166/7206	9.03522698057e-06
ko04360	Axon guidance	61/1103	233/7206	1.15996005859e-05
ko05322	Systemic lupus erythematosus	6/1103	151/7206	1.65495986295e-05
ko04010	MAPK signaling pathway	77/1103	321/7206	3.24717583128e-05
ko04745	Phototransduction - fly	16/1103	38/7206	6.4138912867e-05
ko04120	Ubiquitin mediated proteolysis	6/1103	138/7206	6.53098673383e-05
ko04612	Antigen processing and presentation	1/1103	77/7206	8.08962671959e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1103	79/7206	9.73495943104e-05
ko04260	Cardiac muscle contraction	30/1103	98/7206	0.000103854224269
ko04141	Protein processing in endoplasmic reticulum	11/1103	184/7206	0.000111295002845
ko04072	Phospholipase D signaling pathway	51/1103	197/7206	0.000114736191314
ko05110	Vibrio cholerae infection	22/1103	63/7206	0.000118268831224
ko04070	Phosphatidylinositol signaling system	33/1103	112/7206	0.000156524532013
ko04064	NF-kappa B signaling pathway	3/1103	96/7206	0.000170195238107
ko04730	Long-term depression	25/1103	78/7206	0.000186030018832
ko04924	Renin secretion	27/1103	86/7206	0.000204273107563
ko04972	Pancreatic secretion	32/1103	111/7206	0.000259181555954
ko05164	Influenza A	10/1103	167/7206	0.000289277272953
ko04110	Cell cycle	8/1103	145/7206	0.00040268244413
ko03008	Ribosome biogenesis in eukaryotes	2/1103	79/7206	0.00041045419431
ko04540	Gap junction	35/1103	128/7206	0.000432517862522
ko05169	Epstein-Barr virus infection	15/1103	206/7206	0.000557928479327
ko05140	Leishmaniasis	2/1103	75/7206	0.000600148995007
ko05414	Dilated cardiomyopathy	31/1103	112/7206	0.000778105391403
ko04976	Bile secretion	24/1103	80/7206	0.000807362189338
ko05205	Proteoglycans in cancer	23/1103	271/7206	0.00101486604851
ko04915	Estrogen signaling pathway	34/1103	131/7206	0.00132819607671
ko04750	Inflammatory mediator regulation of TRP channels	32/1103	122/7206	0.00143670887433
ko04014	Ras signaling pathway	62/1103	279/7206	0.0016572323637
ko05162	Measles	7/1103	120/7206	0.00198034454691
ko00480	Glutathione metabolism	1/1103	55/7206	0.00208972936846
ko04610	Complement and coagulation cascades	3/1103	79/7206	0.00236621794324
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1103	14/7206	0.00246311772518
ko05161	Hepatitis B	13/1103	173/7206	0.00261680654848
ko04626	Plant-pathogen interaction	8/1103	18/7206	0.00306053715274
ko04330	Notch signaling pathway	2/1103	62/7206	0.00409082594668
ko00562	Inositol phosphate metabolism	24/1103	89/7206	0.00433484005495
ko05166	HTLV-I infection	28/1103	292/7206	0.00464912313242
ko04350	TGF-beta signaling pathway	6/1103	103/7206	0.00530189978963
ko03420	Nucleotide excision repair	1/1103	46/7206	0.00694862742036
ko00240	Pyrimidine metabolism	7/1103	110/7206	0.00702292929842
ko04146	Peroxisome	5/1103	89/7206	0.00725693737702
ko05219	Bladder cancer	1/1103	48/7206	0.00732734368975
ko05206	MicroRNAs in cancer	15/1103	177/7206	0.00812350689439
ko04964	Proximal tubule bicarbonate reclamation	10/1103	29/7206	0.0084315948234
ko05321	Inflammatory bowel disease (IBD)	2/1103	56/7206	0.00869256457301
ko04973	Carbohydrate digestion and absorption	13/1103	42/7206	0.00885013782053
ko04657	IL-17 signaling pathway	5/1103	87/7206	0.0101127663991
ko03022	Basal transcription factors	1/1103	44/7206	0.0104203625495
ko04510	Focal adhesion	23/1103	240/7206	0.0105210051688
ko04371	Apelin signaling pathway	40/1103	177/7206	0.0106997680559
ko05144	Malaria	1/1103	45/7206	0.0107574029721
ko00071	Fatty acid degradation	1/1103	45/7206	0.0107574029721
ko05016	Huntington's disease	20/1103	215/7206	0.0120772865178
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1103	92/7206	0.0129692935865
ko03018	RNA degradation	5/1103	84/7206	0.01389859023
ko04923	Regulation of lipolysis in adipocytes	20/1103	77/7206	0.0155971106657
ko04961	Endocrine and other factor-regulated calcium reabsorption	16/1103	59/7206	0.0171820385738
ko05145	Toxoplasmosis	10/1103	126/7206	0.0174425641825
ko05131	Shigellosis	5/1103	82/7206	0.0193565396095
ko00330	Arginine and proline metabolism	3/1103	61/7206	0.0193950707197
ko04622	RIG-I-like receptor signaling pathway	3/1103	62/7206	0.0196818893488
ko04214	Apoptosis - fly	4/1103	72/7206	0.0198302779003
ko04912	GnRH signaling pathway	28/1103	122/7206	0.0222335056583
ko00630	Glyoxylate and dicarboxylate metabolism	1/1103	38/7206	0.0229895497356
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1103	100/7206	0.0239257973781
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1103	40/7206	0.0242760468863
ko05133	Pertussis	6/1103	87/7206	0.0244297500006
ko04922	Glucagon signaling pathway	29/1103	128/7206	0.0252218936664
ko05217	Basal cell carcinoma	4/1103	68/7206	0.0270294215689
ko04630	Jak-STAT signaling pathway	11/1103	132/7206	0.02709069023
ko04710	Circadian rhythm	12/1103	43/7206	0.0311903063272
ko04114	Oocyte meiosis	31/1103	139/7206	0.0312427986227
ko05215	Prostate cancer	9/1103	111/7206	0.0329265606945
ko00512	Mucin type O-glycan biosynthesis	9/1103	29/7206	0.0329652123478
ko00500	Starch and sucrose metabolism	1/1103	35/7206	0.0341535926807
ko00982	Drug metabolism - cytochrome P450	1/1103	37/7206	0.0354762151823
ko04930	Type II diabetes mellitus	14/1103	54/7206	0.0365277268818
ko05200	Pathways in cancer	59/1103	492/7206	0.0376545911153
ko04978	Mineral absorption	11/1103	40/7206	0.0443070653072
ko04210	Apoptosis	18/1103	180/7206	0.0460650206662
ko04062	Chemokine signaling pathway	41/1103	201/7206	0.0467273020911
ko04960	Aldosterone-regulated sodium reabsorption	11/1103	41/7206	0.0491062243173
ko04115	p53 signaling pathway	5/1103	74/7206	0.0492004844697