ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	191/1186	423/7206	7.44542174108e-47
ko04724	Glutamatergic synapse	86/1186	152/7206	4.86824542928e-30
ko05033	Nicotine addiction	46/1186	56/7206	2.80657880207e-27
ko05032	Morphine addiction	66/1186	110/7206	2.73541966716e-25
ko04727	GABAergic synapse	65/1186	110/7206	2.15048705653e-24
ko04713	Circadian entrainment	70/1186	136/7206	2.1079140939e-21
ko04725	Cholinergic synapse	77/1186	160/7206	4.18196246754e-21
ko04728	Dopaminergic synapse	81/1186	185/7206	6.20673979341e-19
ko04721	Synaptic vesicle cycle	48/1186	80/7206	1.05192492102e-18
ko04024	cAMP signaling pathway	105/1186	279/7206	4.5262239022e-18
ko04723	Retrograde endocannabinoid signaling	76/1186	175/7206	1.39617302125e-17
ko04020	Calcium signaling pathway	96/1186	265/7206	1.82041731738e-15
ko04744	Phototransduction	27/1186	36/7206	1.11404481929e-14
ko04911	Insulin secretion	54/1186	117/7206	3.5186113033e-14
ko04742	Taste transduction	36/1186	61/7206	4.98297940525e-14
ko04726	Serotonergic synapse	58/1186	137/7206	4.07920959111e-13
ko04921	Oxytocin signaling pathway	76/1186	209/7206	1.61476172314e-12
ko04261	Adrenergic signaling in cardiomyocytes	74/1186	205/7206	4.53731377154e-12
ko03040	Spliceosome	1/1186	145/7206	1.92711451944e-10
ko04970	Salivary secretion	41/1186	95/7206	5.82420975289e-10
ko05031	Amphetamine addiction	38/1186	91/7206	7.62882669671e-09
ko04720	Long-term potentiation	40/1186	99/7206	9.62393853373e-09
ko05203	Viral carcinogenesis	16/1186	277/7206	8.19107000914e-08
ko05322	Systemic lupus erythematosus	4/1186	151/7206	8.74275309503e-08
ko04925	Aldosterone synthesis and secretion	38/1186	105/7206	7.87803919882e-07
ko04022	cGMP-PKG signaling pathway	64/1186	216/7206	9.00306586602e-07
ko04971	Gastric acid secretion	36/1186	98/7206	1.26752018478e-06
ko03013	RNA transport	7/1186	166/7206	1.2762976014e-06
ko04740	Olfactory transduction	31/1186	80/7206	1.83671032503e-06
ko04070	Phosphatidylinositol signaling system	39/1186	112/7206	1.88957607291e-06
ko04360	Axon guidance	67/1186	233/7206	2.20580727274e-06
ko05168	Herpes simplex infection	9/1186	182/7206	2.35241363822e-06
ko04060	Cytokine-cytokine receptor interaction	10/1186	191/7206	2.55806652484e-06
ko04072	Phospholipase D signaling pathway	58/1186	197/7206	3.59280441434e-06
ko04514	Cell adhesion molecules (CAMs)	42/1186	130/7206	6.64352768964e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1186	74/7206	8.87954859759e-06
ko04972	Pancreatic secretion	37/1186	111/7206	1.24770515065e-05
ko04966	Collecting duct acid secretion	14/1186	26/7206	1.34986394142e-05
ko04621	NOD-like receptor signaling pathway	8/1186	157/7206	1.75289080472e-05
ko05164	Influenza A	9/1186	167/7206	1.87463093246e-05
ko05030	Cocaine addiction	27/1186	73/7206	1.91958162562e-05
ko04120	Ubiquitin mediated proteolysis	7/1186	138/7206	6.49108871215e-05
ko04141	Protein processing in endoplasmic reticulum	12/1186	184/7206	7.28574010153e-05
ko04010	MAPK signaling pathway	80/1186	321/7206	7.71790729866e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1186	79/7206	9.71180242098e-05
ko04745	Phototransduction - fly	16/1186	38/7206	0.000156595380762
ko04923	Regulation of lipolysis in adipocytes	26/1186	77/7206	0.000160898655494
ko03008	Ribosome biogenesis in eukaryotes	2/1186	79/7206	0.000173318221164
ko04976	Bile secretion	27/1186	80/7206	0.000184669960668
ko05414	Dilated cardiomyopathy	34/1186	112/7206	0.000251458364053
ko05140	Leishmaniasis	2/1186	75/7206	0.000251458505775
ko04730	Long-term depression	26/1186	78/7206	0.000287082546044
ko04915	Estrogen signaling pathway	38/1186	131/7206	0.000297228304925
ko04540	Gap junction	37/1186	128/7206	0.000403329881023
ko04064	NF-kappa B signaling pathway	4/1186	96/7206	0.000413926044423
ko04014	Ras signaling pathway	68/1186	279/7206	0.000513983961294
ko04924	Renin secretion	27/1186	86/7206	0.00059396638433
ko04750	Inflammatory mediator regulation of TRP channels	35/1186	122/7206	0.000746463264538
ko05110	Vibrio cholerae infection	21/1186	63/7206	0.000907564202727
ko04110	Cell cycle	10/1186	145/7206	0.000926903712837
ko04626	Plant-pathogen interaction	9/1186	18/7206	0.001013054388
ko04612	Antigen processing and presentation	3/1186	77/7206	0.00102495870229
ko04610	Complement and coagulation cascades	3/1186	79/7206	0.00107547652642
ko04964	Proximal tubule bicarbonate reclamation	12/1186	29/7206	0.00125078569098
ko00562	Inositol phosphate metabolism	27/1186	89/7206	0.00127071863596
ko04260	Cardiac muscle contraction	29/1186	98/7206	0.00134691586753
ko05161	Hepatitis B	14/1186	173/7206	0.00172537711332
ko05205	Proteoglycans in cancer	27/1186	271/7206	0.00254564025052
ko05169	Epstein-Barr virus infection	19/1186	206/7206	0.003063691337
ko05144	Malaria	1/1186	45/7206	0.00440886093619
ko00071	Fatty acid degradation	1/1186	45/7206	0.00440886093619
ko03420	Nucleotide excision repair	1/1186	46/7206	0.00440935163356
ko00480	Glutathione metabolism	2/1186	55/7206	0.00565192170223
ko05162	Measles	9/1186	120/7206	0.00591112626073
ko00240	Pyrimidine metabolism	8/1186	110/7206	0.00624221065598
ko03022	Basal transcription factors	1/1186	44/7206	0.00671997025124
ko04115	p53 signaling pathway	4/1186	74/7206	0.00681310975652
ko04371	Apelin signaling pathway	43/1186	177/7206	0.00725966625351
ko00590	Arachidonic acid metabolism	2/1186	52/7206	0.00828224750215
ko05231	Choline metabolism in cancer	34/1186	134/7206	0.00911552537273
ko04622	RIG-I-like receptor signaling pathway	3/1186	62/7206	0.00919128638856
ko04146	Peroxisome	6/1186	89/7206	0.00932634122136
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1186	40/7206	0.00992152236291
ko04217	Necroptosis	17/1186	178/7206	0.0102339435942
ko04658	Th1 and Th2 cell differentiation	7/1186	96/7206	0.0120944253001
ko04657	IL-17 signaling pathway	6/1186	87/7206	0.0127752769913
ko05133	Pertussis	6/1186	87/7206	0.0127752769913
ko00330	Arginine and proline metabolism	3/1186	61/7206	0.0136418403495
ko03410	Base excision repair	1/1186	38/7206	0.0147989272586
ko04930	Type II diabetes mellitus	16/1186	54/7206	0.015018779189
ko05145	Toxoplasmosis	11/1186	126/7206	0.0151915604452
ko04510	Focal adhesion	26/1186	240/7206	0.0165045302479
ko04722	Neurotrophin signaling pathway	38/1186	160/7206	0.0171003665456
ko03018	RNA degradation	6/1186	84/7206	0.0173602194593
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1186	14/7206	0.0178773477486
ko05321	Inflammatory bowel disease (IBD)	3/1186	56/7206	0.0186566205758
ko04973	Carbohydrate digestion and absorption	13/1186	42/7206	0.0192081366987
ko04015	Rap1 signaling pathway	60/1186	278/7206	0.0209649934272
ko04710	Circadian rhythm	13/1186	43/7206	0.0217249653559
ko00500	Starch and sucrose metabolism	1/1186	35/7206	0.0221599028831
ko00982	Drug metabolism - cytochrome P450	1/1186	37/7206	0.023072830986
ko05131	Shigellosis	6/1186	82/7206	0.0236549246068
ko04214	Apoptosis - fly	5/1186	72/7206	0.0249869209218
ko04640	Hematopoietic cell lineage	4/1186	64/7206	0.0262727709837
ko00280	Valine, leucine and isoleucine degradation	3/1186	54/7206	0.0263382657838
ko04270	Vascular smooth muscle contraction	36/1186	154/7206	0.0272255845983
ko04918	Thyroid hormone synthesis	22/1186	86/7206	0.0276002910282
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1186	100/7206	0.0286336425576
ko04961	Endocrine and other factor-regulated calcium reabsorption	16/1186	59/7206	0.0336516768578
ko05166	HTLV-I infection	35/1186	292/7206	0.0359679444436
ko04062	Chemokine signaling pathway	44/1186	201/7206	0.0422233692404
ko04711	Circadian rhythm - fly	5/1186	13/7206	0.0486293817771