ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	211/1293	423/7206	2.107479112e-54
ko04724	Glutamatergic synapse	88/1293	152/7206	7.8390716507e-29
ko05033	Nicotine addiction	46/1293	56/7206	1.34921595602e-25
ko04713	Circadian entrainment	78/1293	136/7206	2.7427765706e-25
ko04020	Calcium signaling pathway	116/1293	265/7206	2.90059240783e-23
ko05032	Morphine addiction	65/1293	110/7206	3.10296192696e-22
ko04727	GABAergic synapse	64/1293	110/7206	2.10696690426e-21
ko04725	Cholinergic synapse	78/1293	160/7206	2.028254818e-19
ko04728	Dopaminergic synapse	85/1293	185/7206	5.63159731578e-19
ko04911	Insulin secretion	62/1293	117/7206	5.74271511248e-18
ko04024	cAMP signaling pathway	108/1293	279/7206	8.93078117197e-17
ko04921	Oxytocin signaling pathway	88/1293	209/7206	1.50778291716e-16
ko04723	Retrograde endocannabinoid signaling	77/1293	175/7206	5.63367314832e-16
ko04261	Adrenergic signaling in cardiomyocytes	82/1293	205/7206	6.89969282211e-14
ko04721	Synaptic vesicle cycle	44/1293	80/7206	6.96512697962e-14
ko04726	Serotonergic synapse	62/1293	137/7206	8.85463964585e-14
ko04742	Taste transduction	36/1293	61/7206	7.57766959041e-13
ko04022	cGMP-PKG signaling pathway	81/1293	216/7206	6.68114355582e-12
ko04970	Salivary secretion	45/1293	95/7206	3.47477884904e-11
ko03040	Spliceosome	2/1293	145/7206	2.23226847211e-10
ko03010	Ribosome	1/1293	129/7206	3.38270627093e-10
ko05031	Amphetamine addiction	42/1293	91/7206	4.3925055197e-10
ko04720	Long-term potentiation	43/1293	99/7206	2.84507202451e-09
ko05322	Systemic lupus erythematosus	4/1293	151/7206	9.41487179203e-09
ko04744	Phototransduction	22/1293	36/7206	9.46592154686e-09
ko04925	Aldosterone synthesis and secretion	43/1293	105/7206	2.50807662315e-08
ko04360	Axon guidance	76/1293	233/7206	4.43309325151e-08
ko04971	Gastric acid secretion	40/1293	98/7206	8.66718428685e-08
ko05203	Viral carcinogenesis	20/1293	277/7206	2.43405544401e-07
ko03013	RNA transport	8/1293	166/7206	5.89568598725e-07
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	33/1293	79/7206	7.4824468711e-07
ko05168	Herpes simplex infection	10/1293	182/7206	1.08369417762e-06
ko04730	Long-term depression	32/1293	78/7206	1.61374002387e-06
ko04740	Olfactory transduction	32/1293	80/7206	2.8880574608e-06
ko04072	Phospholipase D signaling pathway	62/1293	197/7206	2.95758461076e-06
ko05414	Dilated cardiomyopathy	40/1293	112/7206	8.51396735134e-06
ko04010	MAPK signaling pathway	89/1293	321/7206	9.77569293632e-06
ko04110	Cell cycle	8/1293	145/7206	1.50604772689e-05
ko04070	Phosphatidylinositol signaling system	39/1293	112/7206	1.64477879485e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1293	74/7206	1.99746818359e-05
ko04972	Pancreatic secretion	38/1293	111/7206	2.99510029872e-05
ko04621	NOD-like receptor signaling pathway	10/1293	157/7206	3.30825097602e-05
ko05030	Cocaine addiction	28/1293	73/7206	3.75017927226e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1293	79/7206	4.43994414999e-05
ko04514	Cell adhesion molecules (CAMs)	42/1293	130/7206	6.77170170251e-05
ko04270	Vascular smooth muscle contraction	48/1293	154/7206	6.80676436801e-05
ko04060	Cytokine-cytokine receptor interaction	15/1293	191/7206	7.90586904486e-05
ko04260	Cardiac muscle contraction	34/1293	98/7206	8.50665236464e-05
ko05164	Influenza A	12/1293	167/7206	8.84807075438e-05
ko04976	Bile secretion	29/1293	80/7206	9.23532944067e-05
ko04930	Type II diabetes mellitus	22/1293	54/7206	9.31500505481e-05
ko04540	Gap junction	41/1293	128/7206	9.97047590535e-05
ko04745	Phototransduction - fly	17/1293	38/7206	0.000118867708463
ko04371	Apelin signaling pathway	52/1293	177/7206	0.000147620206786
ko04710	Circadian rhythm	18/1293	43/7206	0.000212966981084
ko05410	Hypertrophic cardiomyopathy (HCM)	33/1293	100/7206	0.000307264399212
ko04924	Renin secretion	29/1293	86/7206	0.000353052108843
ko04612	Antigen processing and presentation	3/1293	77/7206	0.000449394411031
ko00520	Amino sugar and nucleotide sugar metabolism	1/1293	55/7206	0.000542217477906
ko04141	Protein processing in endoplasmic reticulum	16/1293	184/7206	0.000591576675313
ko04964	Proximal tubule bicarbonate reclamation	13/1293	29/7206	0.000734835678602
ko04750	Inflammatory mediator regulation of TRP channels	37/1293	122/7206	0.000757271149483
ko04610	Complement and coagulation cascades	4/1293	79/7206	0.00107217607089
ko04120	Ubiquitin mediated proteolysis	11/1293	138/7206	0.00108648317743
ko05169	Epstein-Barr virus infection	20/1293	206/7206	0.00118553541933
ko04014	Ras signaling pathway	71/1293	279/7206	0.00139730912786
ko03420	Nucleotide excision repair	1/1293	46/7206	0.0017820822519
ko05140	Leishmaniasis	4/1293	75/7206	0.00220016625908
ko03022	Basal transcription factors	1/1293	44/7206	0.00268850697869
ko04146	Peroxisome	6/1293	89/7206	0.00330232253686
ko05161	Hepatitis B	17/1293	173/7206	0.00351049099737
ko04915	Estrogen signaling pathway	37/1293	131/7206	0.00375031865361
ko05162	Measles	10/1293	120/7206	0.00380724650202
ko04960	Aldosterone-regulated sodium reabsorption	15/1293	41/7206	0.0038145361694
ko04622	RIG-I-like receptor signaling pathway	3/1293	62/7206	0.00416523496414
ko04064	NF-kappa B signaling pathway	7/1293	96/7206	0.00451066747121
ko04922	Glucagon signaling pathway	36/1293	128/7206	0.00489460102552
ko00590	Arachidonic acid metabolism	2/1293	52/7206	0.00547245052453
ko00240	Pyrimidine metabolism	9/1293	110/7206	0.00550402923289
ko04142	Lysosome	15/1293	151/7206	0.00728051751457
ko05110	Vibrio cholerae infection	20/1293	63/7206	0.00748720352102
ko04916	Melanogenesis	38/1293	142/7206	0.00783945839092
ko04626	Plant-pathogen interaction	8/1293	18/7206	0.0083771391303
ko04672	Intestinal immune network for IgA production	1/1293	37/7206	0.00927768738726
ko03410	Base excision repair	1/1293	38/7206	0.00941099278497
ko04217	Necroptosis	19/1293	178/7206	0.00978284419702
ko05166	HTLV-I infection	36/1293	292/7206	0.0100166453774
ko04923	Regulation of lipolysis in adipocytes	23/1293	77/7206	0.0102793166513
ko00280	Valine, leucine and isoleucine degradation	3/1293	54/7206	0.0123497745573
ko05321	Inflammatory bowel disease (IBD)	3/1293	56/7206	0.0128632254661
ko04973	Carbohydrate digestion and absorption	14/1293	42/7206	0.0144056366932
ko05016	Huntington's disease	25/1293	215/7206	0.0144762574853
ko04657	IL-17 signaling pathway	7/1293	87/7206	0.0158266847198
ko05133	Pertussis	7/1293	87/7206	0.0158266847198
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1293	59/7206	0.0164165160287
ko05231	Choline metabolism in cancer	35/1293	134/7206	0.0166396095262
ko04966	Collecting duct acid secretion	10/1293	26/7206	0.0167610687813
ko05144	Malaria	2/1293	45/7206	0.0172283216045
ko00071	Fatty acid degradation	2/1293	45/7206	0.0172283216045
ko04113	Meiosis - yeast	5/1293	70/7206	0.0176111727102
ko04711	Circadian rhythm - fly	6/1293	13/7206	0.0179714231667
ko05205	Proteoglycans in cancer	34/1293	271/7206	0.0189621645532
ko05230	Central carbon metabolism in cancer	23/1293	81/7206	0.0190358760584
ko04015	Rap1 signaling pathway	65/1293	278/7206	0.0204778880584
ko04115	p53 signaling pathway	6/1293	74/7206	0.0224138758953
ko04912	GnRH signaling pathway	32/1293	122/7206	0.0229426733319
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1293	14/7206	0.0267676860794
ko04152	AMPK signaling pathway	40/1293	161/7206	0.0284733087293
ko05131	Shigellosis	7/1293	82/7206	0.0285344378987
ko04630	Jak-STAT signaling pathway	14/1293	132/7206	0.0288182122284
ko04214	Apoptosis - fly	6/1293	72/7206	0.0303195395069
ko00310	Lysine degradation	6/1293	73/7206	0.0305820735928
ko04658	Th1 and Th2 cell differentiation	9/1293	96/7206	0.030958654378
ko05340	Primary immunodeficiency	1/1293	30/7206	0.0314729653531
ko04932	Non-alcoholic fatty liver disease (NAFLD)	22/1293	182/7206	0.0394024697119
ko00680	Methane metabolism	11/1293	34/7206	0.0406071984757
ko04330	Notch signaling pathway	5/1293	62/7206	0.0446997078569
ko00010	Glycolysis / Gluconeogenesis	20/1293	74/7206	0.0473508624407
ko04210	Apoptosis	22/1293	180/7206	0.0484521344416