ko pathway ratio_in_study ratio_in_pop p_value ko04380 Osteoclast differentiation 26/306 134/7206 4.39393534463e-11 ko05340 Primary immunodeficiency 13/306 30/7206 7.08973144581e-11 ko04621 NOD-like receptor signaling pathway 26/306 157/7206 1.6641734904e-09 ko04658 Th1 and Th2 cell differentiation 20/306 96/7206 2.26030815059e-09 ko05164 Influenza A 26/306 167/7206 6.4698322603e-09 ko04064 NF-kappa B signaling pathway 19/306 96/7206 1.4124988057e-08 ko04610 Complement and coagulation cascades 17/306 79/7206 2.23147375562e-08 ko04659 Th17 cell differentiation 19/306 106/7206 7.6352142908e-08 ko04060 Cytokine-cytokine receptor interaction 26/306 191/7206 1.10063182957e-07 ko05162 Measles 20/306 120/7206 1.2159132444e-07 ko04620 Toll-like receptor signaling pathway 18/306 100/7206 1.58610688002e-07 ko05168 Herpes simplex infection 25/306 182/7206 1.63427548035e-07 ko04660 T cell receptor signaling pathway 20/306 124/7206 2.12468042603e-07 ko05145 Toxoplasmosis 20/306 126/7206 2.78249715098e-07 ko05152 Tuberculosis 25/306 187/7206 2.7831271207e-07 ko05321 Inflammatory bowel disease (IBD) 13/306 56/7206 4.11658435834e-07 ko05140 Leishmaniasis 15/306 75/7206 4.23265904541e-07 ko05150 Staphylococcus aureus infection 10/306 36/7206 1.56467450727e-06 ko04672 Intestinal immune network for IgA production 10/306 37/7206 2.06446654726e-06 ko04650 Natural killer cell mediated cytotoxicity 16/306 97/7206 2.64023687523e-06 ko04612 Antigen processing and presentation 13/306 77/7206 1.78897636686e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 21/306 191/7206 5.4537172248e-05 ko04217 Necroptosis 20/306 178/7206 6.0402540061e-05 ko05323 Rheumatoid arthritis 13/306 89/7206 8.65043453885e-05 ko05320 Autoimmune thyroid disease 7/306 29/7206 0.000161806529141 ko04611 Platelet activation 18/306 163/7206 0.000176215438678 ko04623 Cytosolic DNA-sensing pathway 8/306 41/7206 0.000270456035838 ko05133 Pertussis 12/306 87/7206 0.000280781308166 ko04662 B cell receptor signaling pathway 12/306 88/7206 0.000312997363139 ko05161 Hepatitis B 18/306 173/7206 0.000370965540168 ko05330 Allograft rejection 6/306 24/7206 0.000392702429377 ko04630 Jak-STAT signaling pathway 15/306 132/7206 0.000446618969094 ko04145 Phagosome 17/306 162/7206 0.000486910774497 ko05310 Asthma 5/306 17/7206 0.000542284787627 ko05160 Hepatitis C 16/306 153/7206 0.000737554349754 ko04622 RIG-I-like receptor signaling pathway 9/306 62/7206 0.00111181566426 ko05142 Chagas disease (American trypanosomiasis) 14/306 130/7206 0.001174916366 ko04640 Hematopoietic cell lineage 9/306 64/7206 0.00140128553264 ko04668 TNF signaling pathway 13/306 120/7206 0.00165429020878 ko04664 Fc epsilon RI signaling pathway 9/306 77/7206 0.00507232621957 ko04666 Fc gamma R-mediated phagocytosis 12/306 122/7206 0.00546924976643 ko05332 Graft-versus-host disease 4/306 18/7206 0.0060823107709 ko04137 Mitophagy - animal 9/306 82/7206 0.00766311039677 ko05416 Viral myocarditis 7/306 55/7206 0.0081878116576 ko00120 Primary bile acid biosynthesis 4/306 20/7206 0.00900781676227 ko03013 RNA transport 1/306 166/7206 0.0103483738978 ko05166 HTLV-I infection 22/306 292/7206 0.0106505158691 ko05144 Malaria 6/306 45/7206 0.0112517019546 ko05134 Legionellosis 8/306 74/7206 0.0127218511725 ko04210 Apoptosis 15/306 180/7206 0.0127734810108 ko04062 Chemokine signaling pathway 16/306 201/7206 0.0187759416106 ko03040 Spliceosome 1/306 145/7206 0.0215998294958 ko00590 Arachidonic acid metabolism 6/306 52/7206 0.0219885277596 ko04724 Glutamatergic synapse 1/306 152/7206 0.0223719370494 ko05131 Shigellosis 8/306 82/7206 0.0225177396382 ko03050 Proteasome 6/306 54/7206 0.0260091838351 ko04072 Phospholipase D signaling pathway 15/306 197/7206 0.0287591277848 ko04713 Circadian entrainment 1/306 136/7206 0.0311100707078 ko04670 Leukocyte transendothelial migration 12/306 151/7206 0.0370753367644 ko01200 Carbon metabolism 1/306 128/7206 0.0447934554158 ko03010 Ribosome 1/306 129/7206 0.0449355222735 ko04940 Type I diabetes mellitus 4/306 32/7206 0.0449756792371