ko pathway ratio_in_study ratio_in_pop p_value ko04621 NOD-like receptor signaling pathway 25/280 157/7206 1.26983783555e-09 ko04060 Cytokine-cytokine receptor interaction 26/280 191/7206 1.78941617861e-08 ko04380 Osteoclast differentiation 21/280 134/7206 3.77452031852e-08 ko05164 Influenza A 23/280 167/7206 9.95675670224e-08 ko05162 Measles 17/280 120/7206 3.30515553416e-06 ko04064 NF-kappa B signaling pathway 15/280 96/7206 3.66219269596e-06 ko00120 Primary bile acid biosynthesis 7/280 20/7206 6.22426545835e-06 ko05150 Staphylococcus aureus infection 9/280 36/7206 6.63387485715e-06 ko04672 Intestinal immune network for IgA production 9/280 37/7206 8.47117211143e-06 ko04658 Th1 and Th2 cell differentiation 14/280 96/7206 1.75801186566e-05 ko04622 RIG-I-like receptor signaling pathway 11/280 62/7206 2.17538505435e-05 ko05168 Herpes simplex infection 20/280 182/7206 2.34309574169e-05 ko04620 Toll-like receptor signaling pathway 14/280 100/7206 2.82283313651e-05 ko05160 Hepatitis C 17/280 153/7206 8.42008598043e-05 ko05340 Primary immunodeficiency 7/280 30/7206 0.000116960534004 ko05140 Leishmaniasis 11/280 75/7206 0.000133793345319 ko05167 Kaposi's sarcoma-associated herpesvirus infection 19/280 191/7206 0.000145911666269 ko04623 Cytosolic DNA-sensing pathway 8/280 41/7206 0.000146835817721 ko00140 Steroid hormone biosynthesis 8/280 41/7206 0.000146835817721 ko04612 Antigen processing and presentation 11/280 77/7206 0.00017034276988 ko04610 Complement and coagulation cascades 11/280 79/7206 0.000215039183052 ko04659 Th17 cell differentiation 13/280 106/7206 0.000216523418774 ko00350 Tyrosine metabolism 7/280 33/7206 0.000222061552903 ko05321 Inflammatory bowel disease (IBD) 9/280 56/7206 0.000269740667589 ko05145 Toxoplasmosis 14/280 126/7206 0.000355513173138 ko00360 Phenylalanine metabolism 5/280 17/7206 0.000359850863475 ko05161 Hepatitis B 17/280 173/7206 0.000376461579147 ko05133 Pertussis 11/280 87/7206 0.000505940033101 ko05323 Rheumatoid arthritis 11/280 89/7206 0.000615906374082 ko04668 TNF signaling pathway 13/280 120/7206 0.000733142416006 ko04660 T cell receptor signaling pathway 13/280 124/7206 0.000999788098263 ko04611 Platelet activation 15/280 163/7206 0.00161519999461 ko04630 Jak-STAT signaling pathway 13/280 132/7206 0.00177981741628 ko05330 Allograft rejection 5/280 24/7206 0.00197690092519 ko04662 B cell receptor signaling pathway 10/280 88/7206 0.00206765874996 ko05332 Graft-versus-host disease 4/280 18/7206 0.00443427200766 ko05320 Autoimmune thyroid disease 5/280 29/7206 0.00471316302453 ko00950 Isoquinoline alkaloid biosynthesis 3/280 10/7206 0.00568365649615 ko05152 Tuberculosis 15/280 187/7206 0.00655953177835 ko05134 Legionellosis 8/280 74/7206 0.00766433189995 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/280 4/7206 0.00857005759562 ko00643 Styrene degradation 2/280 4/7206 0.00857005759562 ko04217 Necroptosis 14/280 178/7206 0.0100438753983 ko04650 Natural killer cell mediated cytotoxicity 9/280 97/7206 0.0127544296372 ko05131 Shigellosis 8/280 82/7206 0.0139013797203 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/280 5/7206 0.0139183244837 ko00281 Geraniol degradation 2/280 5/7206 0.0139183244837 ko04062 Chemokine signaling pathway 15/280 201/7206 0.0142946563381 ko04210 Apoptosis 14/280 180/7206 0.0163246890428 ko05169 Epstein-Barr virus infection 15/280 206/7206 0.0164649483511 ko05416 Viral myocarditis 6/280 55/7206 0.0191510229533 ko04933 AGE-RAGE signaling pathway in diabetic complications 11/280 135/7206 0.0201946124994 ko00362 Benzoate degradation 2/280 6/7206 0.0203455657813 ko04550 Signaling pathways regulating pluripotency of stem cells 1/280 165/7206 0.0222565969817 ko05034 Alcoholism 3/280 238/7206 0.0261281445583 ko05310 Asthma 3/280 17/7206 0.0263470046142 ko05166 HTLV-I infection 19/280 292/7206 0.0284305968386 ko04724 Glutamatergic synapse 1/280 152/7206 0.0315026655916 ko04512 ECM-receptor interaction 7/280 79/7206 0.0332128604747 ko04940 Type I diabetes mellitus 4/280 32/7206 0.034098305729 ko05142 Chagas disease (American trypanosomiasis) 10/280 130/7206 0.0350559706141 ko04145 Phagosome 12/280 162/7206 0.0352194084672 ko00401 Novobiocin biosynthesis 1/280 1/7206 0.0388565084651 ko04120 Ubiquitin mediated proteolysis 1/280 138/7206 0.0449425820138 ko04916 Melanogenesis 1/280 142/7206 0.0453530268948