ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	198/1186	423/7206	9.73307920556e-52
ko04724	Glutamatergic synapse	87/1186	152/7206	6.79190950243e-31
ko05033	Nicotine addiction	48/1186	56/7206	3.98395858197e-30
ko05032	Morphine addiction	68/1186	110/7206	3.94334917599e-27
ko04713	Circadian entrainment	76/1186	136/7206	3.60938305483e-26
ko04727	GABAergic synapse	66/1186	110/7206	2.73541966716e-25
ko04721	Synaptic vesicle cycle	51/1186	80/7206	1.67860308636e-21
ko04728	Dopaminergic synapse	84/1186	185/7206	7.54870611231e-21
ko04725	Cholinergic synapse	75/1186	160/7206	9.92421811323e-20
ko04723	Retrograde endocannabinoid signaling	77/1186	175/7206	3.33985193985e-18
ko04024	cAMP signaling pathway	104/1186	279/7206	1.06790979747e-17
ko04020	Calcium signaling pathway	98/1186	265/7206	1.76989186995e-16
ko04742	Taste transduction	37/1186	61/7206	6.39562210604e-15
ko04911	Insulin secretion	55/1186	117/7206	7.58659419424e-15
ko04921	Oxytocin signaling pathway	79/1186	209/7206	6.42340020152e-14
ko04726	Serotonergic synapse	59/1186	137/7206	1.02661198521e-13
ko04744	Phototransduction	26/1186	36/7206	1.57438343183e-13
ko04261	Adrenergic signaling in cardiomyocytes	75/1186	205/7206	1.95348745285e-12
ko04970	Salivary secretion	43/1186	95/7206	3.30831402609e-11
ko04720	Long-term potentiation	43/1186	99/7206	1.72001553265e-10
ko03040	Spliceosome	1/1186	145/7206	1.92711451944e-10
ko05031	Amphetamine addiction	40/1186	91/7206	4.83917657897e-10
ko04740	Olfactory transduction	35/1186	80/7206	6.90317759598e-09
ko04360	Axon guidance	73/1186	233/7206	1.35076136015e-08
ko05203	Viral carcinogenesis	15/1186	277/7206	1.99221328343e-08
ko04060	Cytokine-cytokine receptor interaction	7/1186	191/7206	4.72545317615e-08
ko05168	Herpes simplex infection	7/1186	182/7206	1.38887630909e-07
ko04022	cGMP-PKG signaling pathway	66/1186	216/7206	1.84406381286e-07
ko04925	Aldosterone synthesis and secretion	39/1186	105/7206	3.36791114418e-07
ko05030	Cocaine addiction	30/1186	73/7206	4.41234941856e-07
ko05322	Systemic lupus erythematosus	5/1186	151/7206	5.88033113225e-07
ko04971	Gastric acid secretion	36/1186	98/7206	1.26752018478e-06
ko03013	RNA transport	7/1186	166/7206	1.2762976014e-06
ko05164	Influenza A	8/1186	167/7206	6.40509099447e-06
ko04924	Renin secretion	31/1186	86/7206	1.09424745331e-05
ko04966	Collecting duct acid secretion	14/1186	26/7206	1.34986394142e-05
ko04010	MAPK signaling pathway	83/1186	321/7206	1.37752351114e-05
ko04070	Phosphatidylinositol signaling system	37/1186	112/7206	1.42248841623e-05
ko04972	Pancreatic secretion	36/1186	111/7206	2.65892020781e-05
ko04730	Long-term depression	28/1186	78/7206	3.55679163476e-05
ko04745	Phototransduction - fly	17/1186	38/7206	3.8331187466e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1186	79/7206	4.08325344778e-05
ko05169	Epstein-Barr virus infection	14/1186	206/7206	5.17217959473e-05
ko04120	Ubiquitin mediated proteolysis	7/1186	138/7206	6.49108871215e-05
ko04621	NOD-like receptor signaling pathway	9/1186	157/7206	7.24279579313e-05
ko04141	Protein processing in endoplasmic reticulum	12/1186	184/7206	7.28574010153e-05
ko04260	Cardiac muscle contraction	32/1186	98/7206	8.32165265193e-05
ko04540	Gap junction	39/1186	128/7206	8.945256881e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	26/1186	74/7206	9.3054744708e-05
ko05110	Vibrio cholerae infection	23/1186	63/7206	0.000102362865806
ko04514	Cell adhesion molecules (CAMs)	39/1186	130/7206	0.000104626478266
ko04610	Complement and coagulation cascades	2/1186	79/7206	0.000173318221164
ko03008	Ribosome biogenesis in eukaryotes	2/1186	79/7206	0.000173318221164
ko04072	Phospholipase D signaling pathway	53/1186	197/7206	0.000184484824593
ko04976	Bile secretion	27/1186	80/7206	0.000184669960668
ko05414	Dilated cardiomyopathy	34/1186	112/7206	0.000251458364053
ko05140	Leishmaniasis	2/1186	75/7206	0.000251458505775
ko04014	Ras signaling pathway	69/1186	279/7206	0.000277418876432
ko04371	Apelin signaling pathway	48/1186	177/7206	0.000286713998524
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1186	59/7206	0.000297771063479
ko05205	Proteoglycans in cancer	24/1186	271/7206	0.000307568815494
ko04964	Proximal tubule bicarbonate reclamation	13/1186	29/7206	0.00030761376322
ko04110	Cell cycle	9/1186	145/7206	0.00038225954734
ko04064	NF-kappa B signaling pathway	4/1186	96/7206	0.000413926044423
ko04750	Inflammatory mediator regulation of TRP channels	35/1186	122/7206	0.000746463264538
ko04146	Peroxisome	4/1186	89/7206	0.000820014525671
ko04612	Antigen processing and presentation	3/1186	77/7206	0.00102495870229
ko04915	Estrogen signaling pathway	36/1186	131/7206	0.00121472652536
ko04214	Apoptosis - fly	3/1186	72/7206	0.00215103988727
ko05162	Measles	8/1186	120/7206	0.0025820754633
ko00330	Arginine and proline metabolism	2/1186	61/7206	0.00266087546465
ko05161	Hepatitis B	15/1186	173/7206	0.00355369352025
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1186	14/7206	0.00378181296715
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1186	100/7206	0.00386318024277
ko05144	Malaria	1/1186	45/7206	0.00440886093619
ko00071	Fatty acid degradation	1/1186	45/7206	0.00440886093619
ko03420	Nucleotide excision repair	1/1186	46/7206	0.00440935163356
ko04626	Plant-pathogen interaction	8/1186	18/7206	0.00487591342415
ko04658	Th1 and Th2 cell differentiation	6/1186	96/7206	0.00504272284899
ko00480	Glutathione metabolism	2/1186	55/7206	0.00565192170223
ko05321	Inflammatory bowel disease (IBD)	2/1186	56/7206	0.0057387908898
ko00240	Pyrimidine metabolism	8/1186	110/7206	0.00624221065598
ko04640	Hematopoietic cell lineage	3/1186	64/7206	0.00642431788328
ko03022	Basal transcription factors	1/1186	44/7206	0.00671997025124
ko00310	Lysine degradation	4/1186	73/7206	0.00681630817809
ko03018	RNA degradation	5/1186	84/7206	0.00701157353906
ko04923	Regulation of lipolysis in adipocytes	22/1186	77/7206	0.00771896136324
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1186	182/7206	0.00811538260881
ko00590	Arachidonic acid metabolism	2/1186	52/7206	0.00828224750215
ko04330	Notch signaling pathway	3/1186	62/7206	0.00919128638856
ko04622	RIG-I-like receptor signaling pathway	3/1186	62/7206	0.00919128638856
ko05166	HTLV-I infection	32/1186	292/7206	0.00968701886983
ko00380	Tryptophan metabolism	2/1186	50/7206	0.012041452977
ko04657	IL-17 signaling pathway	6/1186	87/7206	0.0127752769913
ko05133	Pertussis	6/1186	87/7206	0.0127752769913
ko00630	Glyoxylate and dicarboxylate metabolism	1/1186	38/7206	0.0147989272586
ko03410	Base excision repair	1/1186	38/7206	0.0147989272586
ko05145	Toxoplasmosis	11/1186	126/7206	0.0151915604452
ko05418	Fluid shear stress and atherosclerosis	17/1186	173/7206	0.0165464573585
ko04217	Necroptosis	18/1186	178/7206	0.0184526505534
ko04912	GnRH signaling pathway	30/1186	122/7206	0.0188894481094
ko04620	Toll-like receptor signaling pathway	8/1186	100/7206	0.0202150097411
ko04015	Rap1 signaling pathway	60/1186	278/7206	0.0209649934272
ko00562	Inositol phosphate metabolism	23/1186	89/7206	0.020994010922
ko04922	Glucagon signaling pathway	31/1186	128/7206	0.0218002525302
ko00500	Starch and sucrose metabolism	1/1186	35/7206	0.0221599028831
ko05131	Shigellosis	6/1186	82/7206	0.0236549246068
ko04115	p53 signaling pathway	5/1186	74/7206	0.0257267788154
ko04350	TGF-beta signaling pathway	9/1186	103/7206	0.0318114113455
ko04210	Apoptosis	19/1186	180/7206	0.0319751958244
ko04140	Autophagy - animal	17/1186	164/7206	0.03280264789
ko04668	TNF signaling pathway	11/1186	120/7206	0.0337258271724
ko04113	Meiosis - yeast	5/1186	70/7206	0.0341930317448
ko04916	Melanogenesis	33/1186	142/7206	0.0386533882214
ko01524	Platinum drug resistance	6/1186	76/7206	0.0426380357575
ko04630	Jak-STAT signaling pathway	13/1186	132/7206	0.0430547663036