ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	131/883	423/7206	3.52800063621e-26
ko04724	Glutamatergic synapse	69/883	152/7206	1.03785103783e-24
ko05033	Nicotine addiction	38/883	56/7206	2.62179333181e-22
ko04721	Synaptic vesicle cycle	45/883	80/7206	2.81018088957e-21
ko04713	Circadian entrainment	57/883	136/7206	1.50621771166e-18
ko04728	Dopaminergic synapse	67/883	185/7206	1.41482292891e-17
ko04727	GABAergic synapse	49/883	110/7206	1.98378947596e-17
ko05032	Morphine addiction	46/883	110/7206	3.77161754169e-15
ko04725	Cholinergic synapse	56/883	160/7206	3.94091705693e-14
ko04723	Retrograde endocannabinoid signaling	56/883	175/7206	2.7922849832e-12
ko04024	cAMP signaling pathway	74/883	279/7206	3.70054729052e-11
ko04911	Insulin secretion	41/883	117/7206	1.066796198e-10
ko04360	Axon guidance	64/883	233/7206	1.57545558898e-10
ko05031	Amphetamine addiction	33/883	91/7206	2.65932444604e-09
ko04742	Taste transduction	25/883	61/7206	1.30324416823e-08
ko04261	Adrenergic signaling in cardiomyocytes	54/883	205/7206	2.68769955328e-08
ko05030	Cocaine addiction	27/883	73/7206	4.63408827386e-08
ko04726	Serotonergic synapse	40/883	137/7206	8.43301290646e-08
ko03040	Spliceosome	1/883	145/7206	2.32840636214e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	26/883	74/7206	2.70758785355e-07
ko04970	Salivary secretion	30/883	95/7206	4.8487346631e-07
ko04060	Cytokine-cytokine receptor interaction	4/883	191/7206	4.87794904146e-07
ko04720	Long-term potentiation	30/883	99/7206	1.29714998427e-06
ko04744	Phototransduction	16/883	36/7206	1.51811747781e-06
ko04514	Cell adhesion molecules (CAMs)	35/883	130/7206	4.41074833381e-06
ko05168	Herpes simplex infection	5/883	182/7206	9.04148642128e-06
ko05203	Viral carcinogenesis	13/883	277/7206	2.14265601462e-05
ko04540	Gap junction	33/883	128/7206	2.74209811722e-05
ko04120	Ubiquitin mediated proteolysis	3/883	138/7206	3.33402280015e-05
ko03013	RNA transport	5/883	166/7206	3.6250094251e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/883	59/7206	4.48812218766e-05
ko04010	MAPK signaling pathway	64/883	321/7206	5.49198111678e-05
ko04966	Collecting duct acid secretion	11/883	26/7206	0.000118172628933
ko04921	Oxytocin signaling pathway	45/883	209/7206	0.000147001108732
ko05164	Influenza A	6/883	167/7206	0.000170501099738
ko04740	Olfactory transduction	22/883	80/7206	0.000194118379725
ko04971	Gastric acid secretion	25/883	98/7206	0.000264647032937
ko04022	cGMP-PKG signaling pathway	45/883	216/7206	0.000293725058036
ko04621	NOD-like receptor signaling pathway	6/883	157/7206	0.000470863507503
ko04020	Calcium signaling pathway	52/883	265/7206	0.000528778518265
ko04915	Estrogen signaling pathway	30/883	131/7206	0.000625837450179
ko05322	Systemic lupus erythematosus	6/883	151/7206	0.000631031714623
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/883	14/7206	0.000636902074526
ko04924	Renin secretion	22/883	86/7206	0.000670708263629
ko03008	Ribosome biogenesis in eukaryotes	1/883	79/7206	0.000763804851785
ko05162	Measles	4/883	120/7206	0.00106620527114
ko04730	Long-term depression	20/883	78/7206	0.00129809518087
ko04146	Peroxisome	2/883	89/7206	0.0015989693511
ko01200	Carbon metabolism	5/883	128/7206	0.00161789813152
ko04972	Pancreatic secretion	25/883	111/7206	0.00198520143622
ko03018	RNA degradation	2/883	84/7206	0.0022524287788
ko04064	NF-kappa B signaling pathway	3/883	96/7206	0.00269302426738
ko04014	Ras signaling pathway	51/883	279/7206	0.0027847669102
ko04141	Protein processing in endoplasmic reticulum	10/883	184/7206	0.00283258152146
ko04640	Hematopoietic cell lineage	1/883	64/7206	0.00361477630459
ko04976	Bile secretion	19/883	80/7206	0.0050811723754
ko04950	Maturity onset diabetes of the young	9/883	29/7206	0.00612257632555
ko04925	Aldosterone synthesis and secretion	23/883	105/7206	0.00614961743179
ko04110	Cell cycle	8/883	145/7206	0.00997653008213
ko04214	Apoptosis - fly	2/883	72/7206	0.0100776827889
ko05110	Vibrio cholerae infection	15/883	63/7206	0.0103401658473
ko00280	Valine, leucine and isoleucine degradation	1/883	54/7206	0.0116928555846
ko04015	Rap1 signaling pathway	48/883	278/7206	0.0117014777111
ko04260	Cardiac muscle contraction	21/883	98/7206	0.0118382570371
ko04962	Vasopressin-regulated water reabsorption	14/883	58/7206	0.0133592725414
ko04391	Hippo signaling pathway - fly	19/883	90/7206	0.0146346774193
ko05034	Alcoholism	42/883	238/7206	0.0152980576666
ko04932	Non-alcoholic fatty liver disease (NAFLD)	12/883	182/7206	0.0158332571505
ko04626	Plant-pathogen interaction	6/883	18/7206	0.0168051880003
ko04750	Inflammatory mediator regulation of TRP channels	24/883	122/7206	0.0171017692887
ko04974	Protein digestion and absorption	20/883	96/7206	0.0172528284332
ko04916	Melanogenesis	27/883	142/7206	0.0191091086909
ko04964	Proximal tubule bicarbonate reclamation	8/883	29/7206	0.0200177687242
ko04072	Phospholipase D signaling pathway	35/883	197/7206	0.0205054780027
ko04745	Phototransduction - fly	10/883	38/7206	0.0206341991882
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	17/883	79/7206	0.0227479051968
ko05204	Chemical carcinogenesis	1/883	48/7206	0.0254439227642
ko00380	Tryptophan metabolism	1/883	50/7206	0.0268449986443
ko00240	Pyrimidine metabolism	6/883	110/7206	0.0269251909547
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/883	15/7206	0.0286120419902
ko00310	Lysine degradation	3/883	73/7206	0.0300474370398
ko00010	Glycolysis / Gluconeogenesis	3/883	74/7206	0.0304512244187
ko05140	Leishmaniasis	3/883	75/7206	0.0311720581703
ko04973	Carbohydrate digestion and absorption	10/883	42/7206	0.0313930650152
ko04930	Type II diabetes mellitus	12/883	54/7206	0.034891101909
ko04371	Apelin signaling pathway	31/883	177/7206	0.0362743182354
ko03022	Basal transcription factors	1/883	44/7206	0.0372260608042
ko05120	Epithelial cell signaling in Helicobacter pylori infection	18/883	92/7206	0.0372869818208
ko05144	Malaria	1/883	45/7206	0.0375373308465
ko00071	Fatty acid degradation	1/883	45/7206	0.0375373308465
ko04145	Phagosome	29/883	162/7206	0.0381669596976
ko03420	Nucleotide excision repair	1/883	46/7206	0.0384407736675
ko03320	PPAR signaling pathway	3/883	69/7206	0.0416775376614
ko05224	Breast cancer	30/883	174/7206	0.0466176703452
ko04217	Necroptosis	13/883	178/7206	0.0479650830016
ko05213	Endometrial cancer	13/883	62/7206	0.0487628556389