ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	165/961	423/7206	6.36230331012e-43
ko04724	Glutamatergic synapse	80/961	152/7206	1.28907221089e-31
ko05033	Nicotine addiction	43/961	56/7206	3.44519579542e-27
ko05032	Morphine addiction	60/961	110/7206	5.09279076169e-25
ko04721	Synaptic vesicle cycle	49/961	80/7206	1.03358485876e-23
ko04727	GABAergic synapse	58/961	110/7206	3.23638421942e-23
ko04713	Circadian entrainment	65/961	136/7206	8.42531105821e-23
ko04728	Dopaminergic synapse	77/961	185/7206	4.09751792307e-22
ko04723	Retrograde endocannabinoid signaling	72/961	175/7206	2.18280704396e-20
ko04725	Cholinergic synapse	66/961	160/7206	7.6381596652e-19
ko04726	Serotonergic synapse	56/961	137/7206	6.04273805838e-16
ko04911	Insulin secretion	49/961	117/7206	1.34157551804e-14
ko04024	cAMP signaling pathway	84/961	279/7206	9.59896724336e-14
ko04742	Taste transduction	32/961	61/7206	2.83946879178e-13
ko04020	Calcium signaling pathway	79/961	265/7206	8.94010946005e-13
ko04921	Oxytocin signaling pathway	66/961	209/7206	5.51212370187e-12
ko05031	Amphetamine addiction	37/961	91/7206	6.97573270463e-11
ko04720	Long-term potentiation	37/961	99/7206	1.20739049307e-09
ko04970	Salivary secretion	36/961	95/7206	1.30070037752e-09
ko04744	Phototransduction	20/961	36/7206	2.31931490855e-09
ko04261	Adrenergic signaling in cardiomyocytes	58/961	205/7206	8.54706640547e-09
ko03040	Spliceosome	1/961	145/7206	3.69653993892e-08
ko04925	Aldosterone synthesis and secretion	35/961	105/7206	1.00636752671e-07
ko04971	Gastric acid secretion	33/961	98/7206	1.77846402082e-07
ko03010	Ribosome	1/961	129/7206	2.88572367977e-07
ko05162	Measles	1/961	120/7206	1.002897504e-06
ko04966	Collecting duct acid secretion	14/961	26/7206	1.04279111185e-06
ko05030	Cocaine addiction	26/961	73/7206	1.06142828841e-06
ko05168	Herpes simplex infection	5/961	182/7206	1.24434642957e-06
ko05164	Influenza A	4/961	167/7206	1.36519948769e-06
ko05322	Systemic lupus erythematosus	4/961	151/7206	8.90729543415e-06
ko05110	Vibrio cholerae infection	22/961	63/7206	1.02969956052e-05
ko04745	Phototransduction - fly	16/961	38/7206	1.10788156385e-05
ko04972	Pancreatic secretion	32/961	111/7206	1.40930964698e-05
ko04730	Long-term depression	25/961	78/7206	1.4720755034e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	24/961	74/7206	1.74024055964e-05
ko05203	Viral carcinogenesis	15/961	277/7206	1.89579610517e-05
ko04540	Gap junction	35/961	128/7206	1.91504431808e-05
ko04514	Cell adhesion molecules (CAMs)	34/961	130/7206	7.20985967129e-05
ko03013	RNA transport	7/961	166/7206	0.000117821275056
ko04750	Inflammatory mediator regulation of TRP channels	32/961	122/7206	0.000123557856243
ko04120	Ubiquitin mediated proteolysis	5/961	138/7206	0.000196702326834
ko05169	Epstein-Barr virus infection	11/961	206/7206	0.000238842780589
ko04141	Protein processing in endoplasmic reticulum	9/961	184/7206	0.000245120748511
ko04022	cGMP-PKG signaling pathway	48/961	216/7206	0.000325657982745
ko04740	Olfactory transduction	23/961	80/7206	0.000342034382989
ko04070	Phosphatidylinositol signaling system	29/961	112/7206	0.000350429630716
ko04630	Jak-STAT signaling pathway	5/961	132/7206	0.000396648213666
ko04510	Focal adhesion	15/961	240/7206	0.000473671717397
ko05205	Proteoglycans in cancer	18/961	271/7206	0.000497629418225
ko04010	MAPK signaling pathway	64/961	321/7206	0.000732622270448
ko04710	Circadian rhythm	14/961	43/7206	0.000937644145762
ko05166	HTLV-I infection	21/961	292/7206	0.00107365928813
ko04110	Cell cycle	7/961	145/7206	0.00117807896522
ko04621	NOD-like receptor signaling pathway	8/961	157/7206	0.0011901417189
ko04626	Plant-pathogen interaction	8/961	18/7206	0.00123253852712
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/961	59/7206	0.00152990646566
ko04072	Phospholipase D signaling pathway	42/961	197/7206	0.00187794917777
ko04924	Renin secretion	22/961	86/7206	0.00203354513325
ko05161	Hepatitis B	10/961	173/7206	0.00203444275591
ko03008	Ribosome biogenesis in eukaryotes	2/961	79/7206	0.00221395192615
ko04371	Apelin signaling pathway	38/961	177/7206	0.00234853057009
ko04060	Cytokine-cytokine receptor interaction	12/961	191/7206	0.00236041592454
ko04915	Estrogen signaling pathway	30/961	131/7206	0.00254509254444
ko04146	Peroxisome	3/961	89/7206	0.00255045070231
ko05222	Small cell lung cancer	3/961	89/7206	0.00255045070231
ko01524	Platinum drug resistance	2/961	76/7206	0.00323320714439
ko00310	Lysine degradation	2/961	73/7206	0.00471229591901
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/961	92/7206	0.00501321550171
ko04210	Apoptosis	12/961	180/7206	0.00535521140074
ko04270	Vascular smooth muscle contraction	33/961	154/7206	0.00541259474052
ko04064	NF-kappa B signaling pathway	4/961	96/7206	0.00576583499114
ko04260	Cardiac muscle contraction	23/961	98/7206	0.00628950090058
ko04014	Ras signaling pathway	53/961	279/7206	0.00681517716997
ko04217	Necroptosis	12/961	178/7206	0.00703219110314
ko04810	Regulation of actin cytoskeleton	21/961	264/7206	0.00728184037237
ko04610	Complement and coagulation cascades	3/961	79/7206	0.00736665885843
ko00280	Valine, leucine and isoleucine degradation	1/961	54/7206	0.00768719352049
ko00520	Amino sugar and nucleotide sugar metabolism	1/961	55/7206	0.00797991552381
ko04922	Glucagon signaling pathway	28/961	128/7206	0.00800864132414
ko04918	Thyroid hormone synthesis	20/961	86/7206	0.010179271645
ko04612	Antigen processing and presentation	3/961	77/7206	0.0105111914429
ko04964	Proximal tubule bicarbonate reclamation	9/961	29/7206	0.0106331029059
ko05215	Prostate cancer	6/961	111/7206	0.0106337579684
ko04932	Non-alcoholic fatty liver disease (NAFLD)	13/961	182/7206	0.0107386288011
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	19/961	79/7206	0.0111451248894
ko04330	Notch signaling pathway	2/961	62/7206	0.0136241523457
ko04668	TNF signaling pathway	7/961	120/7206	0.0138728624553
ko04115	p53 signaling pathway	3/961	74/7206	0.0148760065667
ko05211	Renal cell carcinoma	5/961	96/7206	0.0148836204779
ko05220	Chronic myeloid leukemia	4/961	85/7206	0.0151269648814
ko05140	Leishmaniasis	3/961	75/7206	0.0152346820978
ko05145	Toxoplasmosis	8/961	126/7206	0.0168703878712
ko05219	Bladder cancer	1/961	48/7206	0.0169198404124
ko04916	Melanogenesis	29/961	142/7206	0.0171750208171
ko04550	Signaling pathways regulating pluripotency of stem cells	12/961	165/7206	0.019838782465
ko05212	Pancreatic cancer	4/961	83/7206	0.0213665985837
ko04214	Apoptosis - fly	3/961	72/7206	0.0215209077556
ko05418	Fluid shear stress and atherosclerosis	13/961	173/7206	0.0228512016627
ko00010	Glycolysis / Gluconeogenesis	17/961	74/7206	0.02345051421
ko05144	Malaria	1/961	45/7206	0.0250391282244
ko00071	Fatty acid degradation	1/961	45/7206	0.0250391282244
ko05034	Alcoholism	44/961	238/7206	0.0251299592275
ko04620	Toll-like receptor signaling pathway	6/961	100/7206	0.0259569390943
ko03420	Nucleotide excision repair	1/961	46/7206	0.0260162106806
ko05416	Viral myocarditis	2/961	55/7206	0.0279641570102
ko00604	Glycosphingolipid biosynthesis - ganglio series	5/961	14/7206	0.0296143289686
ko04962	Vasopressin-regulated water reabsorption	14/961	58/7206	0.0298549611012
ko04912	GnRH signaling pathway	25/961	122/7206	0.0302674187869
ko00240	Pyrimidine metabolism	7/961	110/7206	0.0325880196802
ko04218	Cellular senescence	14/961	177/7206	0.0326890692771
ko05414	Dilated cardiomyopathy	23/961	112/7206	0.0341374465163
ko00140	Steroid hormone biosynthesis	1/961	41/7206	0.0362370323821
ko05218	Melanoma	5/961	85/7206	0.0373108542199
ko00680	Methane metabolism	9/961	34/7206	0.0378573460875
ko05323	Rheumatoid arthritis	19/961	89/7206	0.0392664678175
ko04933	AGE-RAGE signaling pathway in diabetic complications	10/961	135/7206	0.0403621055376
ko04664	Fc epsilon RI signaling pathway	4/961	77/7206	0.0407188966414
ko05224	Breast cancer	14/961	174/7206	0.0412609654496
ko04114	Oocyte meiosis	27/961	139/7206	0.0426706077457
ko04660	T cell receptor signaling pathway	9/961	124/7206	0.0450254033539
ko04611	Platelet activation	13/961	163/7206	0.0465510938653
ko04658	Th1 and Th2 cell differentiation	6/961	96/7206	0.0474433426471