ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	205/1335	423/7206	9.45191951323e-48
ko04724	Glutamatergic synapse	93/1335	152/7206	5.93581811728e-32
ko05032	Morphine addiction	71/1335	110/7206	1.10499555441e-26
ko05033	Nicotine addiction	47/1335	56/7206	2.61409119614e-26
ko04727	GABAergic synapse	70/1335	110/7206	9.09160339947e-26
ko04713	Circadian entrainment	78/1335	136/7206	2.38179197314e-24
ko04721	Synaptic vesicle cycle	54/1335	80/7206	5.95837189192e-22
ko04728	Dopaminergic synapse	89/1335	185/7206	1.57398765716e-20
ko04725	Cholinergic synapse	79/1335	160/7206	3.32715602891e-19
ko04024	cAMP signaling pathway	111/1335	279/7206	2.75716113024e-17
ko04020	Calcium signaling pathway	105/1335	265/7206	3.19245070418e-16
ko04723	Retrograde endocannabinoid signaling	79/1335	175/7206	4.20919600991e-16
ko04726	Serotonergic synapse	66/1335	137/7206	1.49671757478e-15
ko04911	Insulin secretion	59/1335	117/7206	3.54951282045e-15
ko04742	Taste transduction	39/1335	61/7206	5.45990783808e-15
ko04921	Oxytocin signaling pathway	84/1335	209/7206	1.39806029679e-13
ko04744	Phototransduction	27/1335	36/7206	2.26764074207e-13
ko03040	Spliceosome	1/1335	145/7206	5.56385358411e-12
ko04970	Salivary secretion	46/1335	95/7206	2.52550900411e-11
ko05031	Amphetamine addiction	44/1335	91/7206	7.30135035138e-11
ko04261	Adrenergic signaling in cardiomyocytes	77/1335	205/7206	1.00321986347e-10
ko04720	Long-term potentiation	45/1335	99/7206	5.82042484924e-10
ko05203	Viral carcinogenesis	18/1335	277/7206	8.27374690754e-09
ko04360	Axon guidance	79/1335	233/7206	1.42169504404e-08
ko04740	Olfactory transduction	36/1335	80/7206	4.26632517335e-08
ko03013	RNA transport	7/1335	166/7206	4.73302916598e-08
ko04022	cGMP-PKG signaling pathway	72/1335	216/7206	1.58151546013e-07
ko05168	Herpes simplex infection	10/1335	182/7206	3.35939288003e-07
ko04060	Cytokine-cytokine receptor interaction	11/1335	191/7206	3.6980172839e-07
ko05322	Systemic lupus erythematosus	7/1335	151/7206	6.7825569318e-07
ko04925	Aldosterone synthesis and secretion	41/1335	105/7206	7.20893165633e-07
ko05030	Cocaine addiction	32/1335	73/7206	7.95128867735e-07
ko04971	Gastric acid secretion	39/1335	98/7206	1.08953019724e-06
ko04966	Collecting duct acid secretion	16/1335	26/7206	1.43656773088e-06
ko04540	Gap junction	46/1335	128/7206	2.68361844697e-06
ko04924	Renin secretion	34/1335	86/7206	4.34454248938e-06
ko04070	Phosphatidylinositol signaling system	41/1335	112/7206	6.08524919645e-06
ko04514	Cell adhesion molecules (CAMs)	45/1335	130/7206	1.05547162199e-05
ko05164	Influenza A	11/1335	167/7206	1.16491241184e-05
ko04976	Bile secretion	31/1335	80/7206	1.813717743e-05
ko04610	Complement and coagulation cascades	2/1335	79/7206	2.79391974985e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1335	79/7206	2.79391974985e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1335	74/7206	2.86407840211e-05
ko04141	Protein processing in endoplasmic reticulum	14/1335	184/7206	3.0750076128e-05
ko04972	Pancreatic secretion	39/1335	111/7206	3.33530319757e-05
ko04010	MAPK signaling pathway	89/1335	321/7206	3.50293074348e-05
ko04745	Phototransduction - fly	18/1335	38/7206	4.55664456694e-05
ko04730	Long-term depression	30/1335	78/7206	4.57153317348e-05
ko04064	NF-kappa B signaling pathway	4/1335	96/7206	5.16852469951e-05
ko04260	Cardiac muscle contraction	35/1335	98/7206	5.88686199457e-05
ko04621	NOD-like receptor signaling pathway	11/1335	157/7206	6.35255196916e-05
ko05140	Leishmaniasis	2/1335	75/7206	6.48422762104e-05
ko04072	Phospholipase D signaling pathway	59/1335	197/7206	8.13135700842e-05
ko05110	Vibrio cholerae infection	25/1335	63/7206	0.000104609145246
ko05169	Epstein-Barr virus infection	18/1335	206/7206	0.000115355734366
ko05205	Proteoglycans in cancer	27/1335	271/7206	0.00011751986496
ko04750	Inflammatory mediator regulation of TRP channels	40/1335	122/7206	0.000138176501359
ko04371	Apelin signaling pathway	53/1335	177/7206	0.000178082382804
ko04923	Regulation of lipolysis in adipocytes	28/1335	77/7206	0.00017965991495
ko05414	Dilated cardiomyopathy	37/1335	112/7206	0.000197866969416
ko04120	Ubiquitin mediated proteolysis	10/1335	138/7206	0.000226182551595
ko04964	Proximal tubule bicarbonate reclamation	14/1335	29/7206	0.000249922203698
ko04110	Cell cycle	11/1335	145/7206	0.000312307941928
ko00520	Amino sugar and nucleotide sugar metabolism	1/1335	55/7206	0.000326979639467
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1335	79/7206	0.00035683819948
ko04626	Plant-pathogen interaction	10/1335	18/7206	0.00047262976454
ko04014	Ras signaling pathway	75/1335	279/7206	0.000507147668941
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1335	59/7206	0.000598551026324
ko04146	Peroxisome	5/1335	89/7206	0.000808657569212
ko05162	Measles	9/1335	120/7206	0.000831485237286
ko04612	Antigen processing and presentation	4/1335	77/7206	0.00102785582278
ko04710	Circadian rhythm	17/1335	43/7206	0.00117448872428
ko05321	Inflammatory bowel disease (IBD)	2/1335	56/7206	0.00157523621092
ko05144	Malaria	1/1335	45/7206	0.00171117468032
ko00071	Fatty acid degradation	1/1335	45/7206	0.00171117468032
ko03420	Nucleotide excision repair	1/1335	46/7206	0.00175371309661
ko04915	Estrogen signaling pathway	39/1335	131/7206	0.00197169539536
ko05161	Hepatitis B	17/1335	173/7206	0.00201545719723
ko00480	Glutathione metabolism	2/1335	55/7206	0.00244434934119
ko03022	Basal transcription factors	1/1335	44/7206	0.00269961486809
ko04622	RIG-I-like receptor signaling pathway	3/1335	62/7206	0.00277249807378
ko04657	IL-17 signaling pathway	6/1335	87/7206	0.00321449142728
ko05133	Pertussis	6/1335	87/7206	0.00321449142728
ko00590	Arachidonic acid metabolism	2/1335	52/7206	0.00349735328704
ko05145	Toxoplasmosis	11/1335	126/7206	0.00352117037695
ko00240	Pyrimidine metabolism	9/1335	110/7206	0.00406015822165
ko03018	RNA degradation	6/1335	84/7206	0.00445120962119
ko00630	Glyoxylate and dicarboxylate metabolism	1/1335	38/7206	0.00598695382739
ko05131	Shigellosis	6/1335	82/7206	0.00618027691196
ko05166	HTLV-I infection	37/1335	292/7206	0.00709580236824
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1335	14/7206	0.00749493806798
ko04658	Th1 and Th2 cell differentiation	8/1335	96/7206	0.00771062134724
ko04922	Glucagon signaling pathway	36/1335	128/7206	0.0078318710864
ko04630	Jak-STAT signaling pathway	13/1335	132/7206	0.0088517033226
ko00310	Lysine degradation	5/1335	73/7206	0.00910448366912
ko05410	Hypertrophic cardiomyopathy (HCM)	29/1335	100/7206	0.00928543160558
ko05231	Choline metabolism in cancer	37/1335	134/7206	0.00941316298818
ko00330	Arginine and proline metabolism	4/1335	61/7206	0.0123524546051
ko00562	Inositol phosphate metabolism	26/1335	89/7206	0.0129189086211
ko04115	p53 signaling pathway	6/1335	74/7206	0.0161157937621
ko04918	Thyroid hormone synthesis	25/1335	86/7206	0.016742977056
ko04217	Necroptosis	21/1335	178/7206	0.0187090645184
ko04930	Type II diabetes mellitus	17/1335	54/7206	0.0208502735187
ko04711	Circadian rhythm - fly	6/1335	13/7206	0.0209198430077
ko04214	Apoptosis - fly	6/1335	72/7206	0.0219260610793
ko04640	Hematopoietic cell lineage	5/1335	64/7206	0.0233054693241
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1335	40/7206	0.0236325237977
ko05219	Bladder cancer	3/1335	48/7206	0.0245744958171
ko04210	Apoptosis	22/1335	180/7206	0.0254453173568
ko04620	Toll-like receptor signaling pathway	10/1335	100/7206	0.0268743089261
ko04015	Rap1 signaling pathway	66/1335	278/7206	0.0271950424332
ko05320	Autoimmune thyroid disease	1/1335	29/7206	0.0309058097194
ko05340	Primary immunodeficiency	1/1335	30/7206	0.0312785844525
ko04912	GnRH signaling pathway	32/1335	122/7206	0.0337455946298
ko00280	Valine, leucine and isoleucine degradation	4/1335	54/7206	0.0339030649635
ko04142	Lysosome	18/1335	151/7206	0.0340472594117
ko03410	Base excision repair	2/1335	38/7206	0.0344972855076
ko04213	Longevity regulating pathway - multiple species	24/1335	86/7206	0.0348386828594
ko05132	Salmonella infection	10/1335	98/7206	0.0352201799405
ko05217	Basal cell carcinoma	6/1335	68/7206	0.0403569318841
ko04960	Aldosterone-regulated sodium reabsorption	13/1335	41/7206	0.0412752325366
ko04973	Carbohydrate digestion and absorption	13/1335	42/7206	0.0457594362537
ko04114	Oocyte meiosis	35/1335	139/7206	0.0469476968828
ko05418	Fluid shear stress and atherosclerosis	22/1335	173/7206	0.0474080679424