ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	193/1197	423/7206	1.44104622211e-47
ko04724	Glutamatergic synapse	85/1197	152/7206	6.78506271692e-29
ko05033	Nicotine addiction	46/1197	56/7206	4.25055557774e-27
ko05032	Morphine addiction	68/1197	110/7206	6.97667321069e-27
ko04713	Circadian entrainment	74/1197	136/7206	2.86034277869e-24
ko04727	GABAergic synapse	65/1197	110/7206	3.67515155437e-24
ko04728	Dopaminergic synapse	84/1197	185/7206	1.40449972374e-20
ko04725	Cholinergic synapse	74/1197	160/7206	8.05981459802e-19
ko04723	Retrograde endocannabinoid signaling	78/1197	175/7206	1.3781079521e-18
ko04742	Taste transduction	40/1197	61/7206	1.25575928271e-17
ko04721	Synaptic vesicle cycle	46/1197	80/7206	8.60643806964e-17
ko04020	Calcium signaling pathway	98/1197	265/7206	4.81236238598e-16
ko04024	cAMP signaling pathway	101/1197	279/7206	7.25160257488e-16
ko04726	Serotonergic synapse	61/1197	137/7206	9.23594032084e-15
ko04744	Phototransduction	27/1197	36/7206	1.41098662148e-14
ko04911	Insulin secretion	54/1197	117/7206	5.23499503153e-14
ko04261	Adrenergic signaling in cardiomyocytes	74/1197	205/7206	6.62250994378e-12
ko04921	Oxytocin signaling pathway	75/1197	209/7206	8.83565765099e-12
ko03040	Spliceosome	1/1197	145/7206	1.19720250041e-10
ko04970	Salivary secretion	41/1197	95/7206	7.77939602744e-10
ko04360	Axon guidance	76/1197	233/7206	9.68280173347e-10
ko05203	Viral carcinogenesis	14/1197	277/7206	4.61155332911e-09
ko04740	Olfactory transduction	35/1197	80/7206	8.85243929623e-09
ko05031	Amphetamine addiction	38/1197	91/7206	9.92310964709e-09
ko05322	Systemic lupus erythematosus	4/1197	151/7206	5.6682600184e-08
ko04971	Gastric acid secretion	38/1197	98/7206	1.23541850532e-07
ko04720	Long-term potentiation	38/1197	99/7206	1.60262803154e-07
ko03013	RNA transport	6/1197	166/7206	2.31510969502e-07
ko05164	Influenza A	6/1197	167/7206	2.40282902537e-07
ko04022	cGMP-PKG signaling pathway	65/1197	216/7206	5.87525265935e-07
ko05030	Cocaine addiction	29/1197	73/7206	1.92677935441e-06
ko04925	Aldosterone synthesis and secretion	37/1197	105/7206	3.57923060739e-06
ko05168	Herpes simplex infection	10/1197	182/7206	7.00560338052e-06
ko04060	Cytokine-cytokine receptor interaction	11/1197	191/7206	7.31749866355e-06
ko04514	Cell adhesion molecules (CAMs)	42/1197	130/7206	7.89354587791e-06
ko04120	Ubiquitin mediated proteolysis	6/1197	138/7206	1.38386243727e-05
ko04621	NOD-like receptor signaling pathway	8/1197	157/7206	1.74812879766e-05
ko04745	Phototransduction - fly	17/1197	38/7206	4.33325859556e-05
ko04972	Pancreatic secretion	36/1197	111/7206	4.6121790461e-05
ko04141	Protein processing in endoplasmic reticulum	12/1197	184/7206	5.25070706733e-05
ko05205	Proteoglycans in cancer	22/1197	271/7206	5.67067803823e-05
ko05169	Epstein-Barr virus infection	15/1197	206/7206	8.85207842955e-05
ko04070	Phosphatidylinositol signaling system	35/1197	112/7206	0.000101122214157
ko05014	Amyotrophic lateral sclerosis (ALS)	26/1197	74/7206	0.0001021066372
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1197	79/7206	0.00011109304804
ko04612	Antigen processing and presentation	2/1197	77/7206	0.000166721482703
ko05162	Measles	6/1197	120/7206	0.000168336382476
ko03008	Ribosome biogenesis in eukaryotes	2/1197	79/7206	0.000178457153136
ko04976	Bile secretion	27/1197	80/7206	0.000195189317074
ko05140	Leishmaniasis	2/1197	75/7206	0.000248744943584
ko05161	Hepatitis B	12/1197	173/7206	0.000254274510872
ko04010	MAPK signaling pathway	78/1197	321/7206	0.000293812168368
ko04540	Gap junction	37/1197	128/7206	0.000437991019669
ko04260	Cardiac muscle contraction	30/1197	98/7206	0.000521732555224
ko04924	Renin secretion	27/1197	86/7206	0.000642665632183
ko04730	Long-term depression	25/1197	78/7206	0.000647564049691
ko04371	Apelin signaling pathway	47/1197	177/7206	0.000676656615001
ko04610	Complement and coagulation cascades	3/1197	79/7206	0.000697288415069
ko05414	Dilated cardiomyopathy	33/1197	112/7206	0.000729497052706
ko04064	NF-kappa B signaling pathway	5/1197	96/7206	0.001278389889
ko04966	Collecting duct acid secretion	11/1197	26/7206	0.00173258260681
ko00240	Pyrimidine metabolism	7/1197	110/7206	0.00184399803661
ko04750	Inflammatory mediator regulation of TRP channels	34/1197	122/7206	0.00190961268614
ko04110	Cell cycle	11/1197	145/7206	0.002146828149
ko04072	Phospholipase D signaling pathway	49/1197	197/7206	0.0025183824736
ko00330	Arginine and proline metabolism	2/1197	61/7206	0.0026946499152
ko00260	Glycine, serine and threonine metabolism	1/1197	48/7206	0.00290308782518
ko04014	Ras signaling pathway	65/1197	279/7206	0.00308711514933
ko04923	Regulation of lipolysis in adipocytes	23/1197	77/7206	0.00318319581911
ko04658	Th1 and Th2 cell differentiation	6/1197	96/7206	0.00354243693997
ko04146	Peroxisome	5/1197	89/7206	0.00364485952583
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1197	14/7206	0.0039919239317
ko00071	Fatty acid degradation	1/1197	45/7206	0.00435533396199
ko03420	Nucleotide excision repair	1/1197	46/7206	0.00442563733313
ko04964	Proximal tubule bicarbonate reclamation	11/1197	29/7206	0.00480186925342
ko00280	Valine, leucine and isoleucine degradation	2/1197	54/7206	0.00563218091999
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1197	182/7206	0.00622507066188
ko05215	Prostate cancer	8/1197	111/7206	0.00639847821474
ko04620	Toll-like receptor signaling pathway	7/1197	100/7206	0.00651631968996
ko03022	Basal transcription factors	1/1197	44/7206	0.00679415595844
ko04140	Autophagy - animal	15/1197	164/7206	0.00770910386164
ko05166	HTLV-I infection	32/1197	292/7206	0.00785918748545
ko00590	Arachidonic acid metabolism	2/1197	52/7206	0.00820488617279
ko04630	Jak-STAT signaling pathway	11/1197	132/7206	0.00890380241946
ko04622	RIG-I-like receptor signaling pathway	3/1197	62/7206	0.00920360338108
ko04710	Circadian rhythm	14/1197	43/7206	0.0113953845968
ko04915	Estrogen signaling pathway	33/1197	131/7206	0.0122198217026
ko04711	Circadian rhythm - fly	6/1197	13/7206	0.0123825218648
ko04657	IL-17 signaling pathway	6/1197	87/7206	0.0128503900546
ko04210	Apoptosis	18/1197	180/7206	0.0145897968665
ko03410	Base excision repair	1/1197	38/7206	0.014756688747
ko05110	Vibrio cholerae infection	18/1197	63/7206	0.0161291262641
ko03018	RNA degradation	6/1197	84/7206	0.0173831782985
ko05219	Bladder cancer	2/1197	48/7206	0.0177071448564
ko04115	p53 signaling pathway	5/1197	74/7206	0.0181236703968
ko04217	Necroptosis	18/1197	178/7206	0.0184965620074
ko04626	Plant-pathogen interaction	7/1197	18/7206	0.0201446934711
ko00500	Starch and sucrose metabolism	1/1197	35/7206	0.0219918825582
ko05131	Shigellosis	6/1197	82/7206	0.023856606239
ko04214	Apoptosis - fly	5/1197	72/7206	0.0249307874249
ko05144	Malaria	2/1197	45/7206	0.0253688772482
ko00310	Lysine degradation	5/1197	73/7206	0.0253708516646
ko04668	TNF signaling pathway	11/1197	120/7206	0.0255579604099
ko00620	Pyruvate metabolism	2/1197	46/7206	0.0261645677195
ko04640	Hematopoietic cell lineage	4/1197	64/7206	0.0265023321585
ko00480	Glutathione metabolism	3/1197	55/7206	0.0269346725383
ko05133	Pertussis	7/1197	87/7206	0.0291084895841
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1197	100/7206	0.0296593029248
ko01200	Carbon metabolism	12/1197	128/7206	0.0300246709093
ko00562	Inositol phosphate metabolism	23/1197	89/7206	0.0301012814527
ko00860	Porphyrin and chlorophyll metabolism	1/1197	34/7206	0.0339412356679
ko04380	Osteoclast differentiation	13/1197	134/7206	0.0339842313315
ko04961	Endocrine and other factor-regulated calcium reabsorption	16/1197	59/7206	0.0351664702808
ko04660	T cell receptor signaling pathway	12/1197	124/7206	0.0378152702963
ko04930	Type II diabetes mellitus	15/1197	54/7206	0.0407966039623
ko01524	Platinum drug resistance	6/1197	76/7206	0.0426915368874
ko04664	Fc epsilon RI signaling pathway	6/1197	77/7206	0.0434909893717
ko04142	Lysosome	16/1197	151/7206	0.0462614933829
ko04270	Vascular smooth muscle contraction	35/1197	154/7206	0.0480493418546
ko05418	Fluid shear stress and atherosclerosis	19/1197	173/7206	0.0487542380901