ko pathway ratio_in_study ratio_in_pop p_value ko00140 Steroid hormone biosynthesis 15/504 41/7206 4.42565885331e-08 ko04060 Cytokine-cytokine receptor interaction 35/504 191/7206 9.55216895268e-08 ko00590 Arachidonic acid metabolism 16/504 52/7206 2.53719099517e-07 ko04974 Protein digestion and absorption 22/504 96/7206 4.92063715925e-07 ko04610 Complement and coagulation cascades 19/504 79/7206 1.36263336313e-06 ko05204 Chemical carcinogenesis 14/504 48/7206 2.94578147502e-06 ko00983 Drug metabolism - other enzymes 13/504 42/7206 3.1883642482e-06 ko00591 Linoleic acid metabolism 9/504 22/7206 8.14376032289e-06 ko00350 Tyrosine metabolism 11/504 33/7206 8.26347354415e-06 ko00643 Styrene degradation 4/504 4/7206 2.36659859665e-05 ko00982 Drug metabolism - cytochrome P450 11/504 37/7206 2.82326356801e-05 ko00120 Primary bile acid biosynthesis 8/504 20/7206 3.21764659118e-05 ko00980 Metabolism of xenobiotics by cytochrome P450 11/504 40/7206 6.2975864769e-05 ko00360 Phenylalanine metabolism 7/504 17/7206 8.23538891278e-05 ko03013 RNA transport 1/504 166/7206 0.000147581793159 ko04390 Hippo signaling pathway 2/504 188/7206 0.000222273708851 ko04976 Bile secretion 15/504 80/7206 0.000362951242811 ko00830 Retinol metabolism 10/504 42/7206 0.000490028788188 ko00380 Tryptophan metabolism 11/504 50/7206 0.000536965342436 ko04621 NOD-like receptor signaling pathway 23/504 157/7206 0.000663960619659 ko04064 NF-kappa B signaling pathway 16/504 96/7206 0.000914479939544 ko00592 alpha-Linolenic acid metabolism 6/504 19/7206 0.00140428578396 ko05321 Inflammatory bowel disease (IBD) 11/504 56/7206 0.00146115621577 ko04972 Pancreatic secretion 17/504 111/7206 0.00198898255058 ko00565 Ether lipid metabolism 9/504 42/7206 0.00207206122458 ko04975 Fat digestion and absorption 8/504 35/7206 0.00236351452437 ko03320 PPAR signaling pathway 12/504 69/7206 0.002696088109 ko04380 Osteoclast differentiation 19/504 134/7206 0.0029561447308 ko00053 Ascorbate and aldarate metabolism 6/504 22/7206 0.00322594406957 ko00950 Isoquinoline alkaloid biosynthesis 4/504 10/7206 0.00353472769525 ko00600 Sphingolipid metabolism 11/504 63/7206 0.00387752555404 ko00564 Glycerophospholipid metabolism 15/504 99/7206 0.00417012822568 ko04550 Signaling pathways regulating pluripotency of stem cells 3/504 165/7206 0.0048092087435 ko04141 Protein processing in endoplasmic reticulum 4/504 184/7206 0.00511422579817 ko00260 Glycine, serine and threonine metabolism 9/504 48/7206 0.0053623929899 ko04120 Ubiquitin mediated proteolysis 2/504 138/7206 0.006022736122 ko04960 Aldosterone-regulated sodium reabsorption 8/504 41/7206 0.00663020105107 ko04070 Phosphatidylinositol signaling system 16/504 112/7206 0.00732416086173 ko00040 Pentose and glucuronate interconversions 6/504 26/7206 0.00784127967286 ko04710 Circadian rhythm 8/504 43/7206 0.0089006029085 ko05034 Alcoholism 7/504 238/7206 0.00927031465259 ko05012 Parkinson's disease 3/504 155/7206 0.00965712195865 ko04659 Th17 cell differentiation 15/504 106/7206 0.0105511753337 ko00561 Glycerolipid metabolism 10/504 63/7206 0.0113668999168 ko00190 Oxidative phosphorylation 2/504 127/7206 0.0123099776516 ko00100 Steroid biosynthesis 5/504 21/7206 0.0130744490344 ko05211 Renal cell carcinoma 1/504 96/7206 0.0140800967628 ko02010 ABC transporters 7/504 39/7206 0.0170410779968 ko05134 Legionellosis 11/504 74/7206 0.0177073284812 ko04978 Mineral absorption 7/504 40/7206 0.0194521363139 ko05164 Influenza A 20/504 167/7206 0.0196042183491 ko04727 GABAergic synapse 2/504 110/7206 0.0235857962713 ko04723 Retrograde endocannabinoid signaling 5/504 175/7206 0.0241491786128 ko00051 Fructose and mannose metabolism 7/504 42/7206 0.0249697949102 ko04360 Axon guidance 8/504 233/7206 0.0261363618793 ko00965 Betalain biosynthesis 2/504 4/7206 0.0266458750083 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/504 4/7206 0.0266458750083 ko00720 Carbon fixation pathways in prokaryotes 4/504 17/7206 0.0271002502588 ko00920 Sulfur metabolism 3/504 10/7206 0.028179447731 ko00860 Porphyrin and chlorophyll metabolism 6/504 34/7206 0.028557438628 ko04662 B cell receptor signaling pathway 12/504 88/7206 0.0313899587804 ko04614 Renin-angiotensin system 4/504 18/7206 0.0329716531659 ko05224 Breast cancer 5/504 174/7206 0.0332470834048 ko05322 Systemic lupus erythematosus 4/504 151/7206 0.0342052616693 ko00130 Ubiquinone and other terpenoid-quinone biosynthesis 3/504 11/7206 0.0367777871196 ko05150 Staphylococcus aureus infection 6/504 36/7206 0.0367892519434 ko05231 Choline metabolism in cancer 16/504 134/7206 0.0373668879378 ko04622 RIG-I-like receptor signaling pathway 9/504 62/7206 0.0382748913609 ko05140 Leishmaniasis 10/504 75/7206 0.0392521918219 ko04658 Th1 and Th2 cell differentiation 12/504 96/7206 0.0422370042314 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/504 5/7206 0.0423715348783 ko05166 HTLV-I infection 12/504 292/7206 0.0463753143238