ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 30/306 152/7206 8.07954885946e-13 ko04020 Calcium signaling pathway 37/306 265/7206 8.65758896164e-11 ko04713 Circadian entrainment 25/306 136/7206 3.56165906252e-10 ko05032 Morphine addiction 22/306 110/7206 7.94447586701e-10 ko04911 Insulin secretion 22/306 117/7206 2.71927291562e-09 ko04728 Dopaminergic synapse 28/306 185/7206 3.16707586065e-09 ko04720 Long-term potentiation 20/306 99/7206 3.9914348631e-09 ko05031 Amphetamine addiction 19/306 91/7206 5.54125366983e-09 ko04925 Aldosterone synthesis and secretion 20/306 105/7206 1.16418453258e-08 ko04727 GABAergic synapse 20/306 110/7206 2.67125012878e-08 ko04723 Retrograde endocannabinoid signaling 25/306 175/7206 7.47493374253e-08 ko04261 Adrenergic signaling in cardiomyocytes 27/306 205/7206 1.24308240983e-07 ko04024 cAMP signaling pathway 32/306 279/7206 2.18056639861e-07 ko04080 Neuroactive ligand-receptor interaction 41/306 423/7206 5.56481687134e-07 ko04912 GnRH signaling pathway 19/306 122/7206 7.53474150264e-07 ko04725 Cholinergic synapse 22/306 160/7206 9.11834253657e-07 ko04070 Phosphatidylinositol signaling system 18/306 112/7206 9.22082198209e-07 ko04921 Oxytocin signaling pathway 24/306 209/7206 7.55637746126e-06 ko04072 Phospholipase D signaling pathway 23/306 197/7206 8.9218682782e-06 ko04915 Estrogen signaling pathway 18/306 131/7206 9.24639410765e-06 ko05030 Cocaine addiction 13/306 73/7206 9.78993353452e-06 ko04022 cGMP-PKG signaling pathway 24/306 216/7206 1.33025640467e-05 ko05033 Nicotine addiction 11/306 56/7206 1.81850785537e-05 ko04742 Taste transduction 11/306 61/7206 4.22317063169e-05 ko05231 Choline metabolism in cancer 17/306 134/7206 4.70527499435e-05 ko04971 Gastric acid secretion 14/306 98/7206 5.96203730553e-05 ko04010 MAPK signaling pathway 29/306 321/7206 9.75642483105e-05 ko04970 Salivary secretion 13/306 95/7206 0.000170737801384 ko04726 Serotonergic synapse 16/306 137/7206 0.000211018894332 ko04540 Gap junction 15/306 128/7206 0.000319447267179 ko04914 Progesterone-mediated oocyte maturation 13/306 104/7206 0.000424635765676 ko04371 Apelin signaling pathway 18/306 177/7206 0.000490192468981 ko04740 Olfactory transduction 11/306 80/7206 0.000515548030667 ko04270 Vascular smooth muscle contraction 16/306 154/7206 0.000792082549695 ko04972 Pancreatic secretion 13/306 111/7206 0.000798588028902 ko04745 Phototransduction - fly 7/306 38/7206 0.000942039706372 ko04924 Renin secretion 11/306 86/7206 0.000959928132514 ko04918 Thyroid hormone synthesis 11/306 86/7206 0.000959928132514 ko00562 Inositol phosphate metabolism 11/306 89/7206 0.00127981908302 ko04923 Regulation of lipolysis in adipocytes 10/306 77/7206 0.00144139559228 ko04730 Long-term depression 10/306 78/7206 0.0015926631468 ko04320 Dorso-ventral axis formation 6/306 31/7206 0.0016718474131 ko05214 Glioma 10/306 79/7206 0.00175656032053 ko04211 Longevity regulating pathway 13/306 123/7206 0.00206999119525 ko04114 Oocyte meiosis 14/306 139/7206 0.00223455078873 ko04922 Glucagon signaling pathway 13/306 128/7206 0.0029520588499 ko00564 Glycerophospholipid metabolism 11/306 99/7206 0.00303315049306 ko04750 Inflammatory mediator regulation of TRP channels 12/306 122/7206 0.00546924976643 ko04012 ErbB signaling pathway 11/306 109/7206 0.00634794067993 ko04360 Axon guidance 19/306 233/7206 0.00701440632963 ko05414 Dilated cardiomyopathy 11/306 112/7206 0.00776086564883 ko05034 Alcoholism 19/306 238/7206 0.00781218171932 ko04916 Melanogenesis 13/306 142/7206 0.00912583693237 ko04145 Phagosome 1/306 162/7206 0.0156070443608 ko00561 Glycerolipid metabolism 7/306 63/7206 0.0167559234211 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 8/306 79/7206 0.0183708194539 ko04062 Chemokine signaling pathway 16/306 201/7206 0.0187759416106 ko04666 Fc gamma R-mediated phagocytosis 11/306 122/7206 0.0190905164706 ko04139 Mitophagy - yeast 5/306 37/7206 0.0190933291889 ko00515 Mannose type O-glycan biosynthesis 4/306 25/7206 0.0199188251131 ko05230 Central carbon metabolism in cancer 8/306 81/7206 0.021068507517 ko04142 Lysosome 1/306 151/7206 0.0221431050091 ko00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 4/306 26/7206 0.0227747741412 ko04011 MAPK signaling pathway - yeast 6/306 53/7206 0.0239423346782 ko04722 Neurotrophin signaling pathway 13/306 160/7206 0.0256463798651 ko04144 Endocytosis 23/306 342/7206 0.0268909428973 ko04213 Longevity regulating pathway - multiple species 8/306 86/7206 0.0290191167275 ko00513 Various types of N-glycan biosynthesis 5/306 42/7206 0.0314106214424 ko00512 Mucin type O-glycan biosynthesis 4/306 29/7206 0.0327761249198 ko04961 Endocrine and other factor-regulated calcium reabsorption 6/306 59/7206 0.038114496424 ko01522 Endocrine resistance 10/306 124/7206 0.0419921562133 ko00190 Oxidative phosphorylation 1/306 127/7206 0.0447253335493 ko04015 Rap1 signaling pathway 19/306 278/7206 0.0462170094928 ko03013 RNA transport 2/306 166/7206 0.0490767367757