ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	178/1041	423/7206	8.30745652823e-47
ko04724	Glutamatergic synapse	92/1041	152/7206	3.56441135725e-40
ko05033	Nicotine addiction	48/1041	56/7206	8.00509252811e-33
ko04713	Circadian entrainment	78/1041	136/7206	7.53486606804e-32
ko05032	Morphine addiction	68/1041	110/7206	1.12462057877e-30
ko04727	GABAergic synapse	64/1041	110/7206	8.86134900077e-27
ko04728	Dopaminergic synapse	84/1041	185/7206	9.28690735198e-25
ko04725	Cholinergic synapse	75/1041	160/7206	2.94342968399e-23
ko04723	Retrograde endocannabinoid signaling	77/1041	175/7206	1.01882902244e-21
ko04024	cAMP signaling pathway	101/1041	279/7206	1.947965139e-20
ko04921	Oxytocin signaling pathway	81/1041	209/7206	1.26199131451e-18
ko04020	Calcium signaling pathway	94/1041	265/7206	2.70001052632e-18
ko04726	Serotonergic synapse	61/1041	137/7206	9.85972643638e-18
ko05031	Amphetamine addiction	46/1041	91/7206	2.65882583536e-16
ko04911	Insulin secretion	53/1041	117/7206	5.8941668091e-16
ko04720	Long-term potentiation	47/1041	99/7206	2.89202865761e-15
ko04721	Synaptic vesicle cycle	41/1041	80/7206	6.17983561287e-15
ko04261	Adrenergic signaling in cardiomyocytes	73/1041	205/7206	2.14146103509e-14
ko04744	Phototransduction	23/1041	36/7206	1.32980169348e-11
ko04742	Taste transduction	31/1041	61/7206	1.74716601069e-11
ko04925	Aldosterone synthesis and secretion	43/1041	105/7206	2.24181642291e-11
ko04970	Salivary secretion	38/1041	95/7206	7.4853958541e-10
ko05030	Cocaine addiction	32/1041	73/7206	1.07069696372e-09
ko04010	MAPK signaling pathway	86/1041	321/7206	3.00180941813e-09
ko04070	Phosphatidylinositol signaling system	41/1041	112/7206	3.74399244048e-09
ko03040	Spliceosome	1/1041	145/7206	5.6782235297e-09
ko04971	Gastric acid secretion	37/1041	98/7206	8.23784859491e-09
ko04022	cGMP-PKG signaling pathway	62/1041	216/7206	3.54076681356e-08
ko03010	Ribosome	1/1041	129/7206	7.43175273221e-08
ko04072	Phospholipase D signaling pathway	57/1041	197/7206	9.21187912383e-08
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1041	74/7206	1.32655304458e-07
ko04360	Axon guidance	62/1041	233/7206	9.05906645068e-07
ko04745	Phototransduction - fly	18/1041	38/7206	1.23922300945e-06
ko04730	Long-term depression	28/1041	78/7206	1.78042174312e-06
ko04740	Olfactory transduction	28/1041	80/7206	3.17130169711e-06
ko04972	Pancreatic secretion	35/1041	111/7206	3.66363502293e-06
ko05322	Systemic lupus erythematosus	5/1041	151/7206	1.01837541923e-05
ko04514	Cell adhesion molecules (CAMs)	38/1041	130/7206	1.17474355175e-05
ko04915	Estrogen signaling pathway	38/1041	131/7206	1.33749609925e-05
ko04540	Gap junction	37/1041	128/7206	1.91943818413e-05
ko04750	Inflammatory mediator regulation of TRP channels	36/1041	122/7206	2.02486327447e-05
ko04060	Cytokine-cytokine receptor interaction	9/1041	191/7206	2.31102341003e-05
ko03013	RNA transport	7/1041	166/7206	2.75406066964e-05
ko04110	Cell cycle	6/1041	145/7206	0.000103280803083
ko05414	Dilated cardiomyopathy	32/1041	112/7206	0.000104609373981
ko05203	Viral carcinogenesis	19/1041	277/7206	0.000110568734365
ko04711	Circadian rhythm - fly	8/1041	13/7206	0.000120887373045
ko04612	Antigen processing and presentation	1/1041	77/7206	0.000126018814051
ko04924	Renin secretion	26/1041	86/7206	0.000147106374173
ko04141	Protein processing in endoplasmic reticulum	10/1041	184/7206	0.000167770961712
ko04710	Circadian rhythm	16/1041	43/7206	0.000181445787831
ko04912	GnRH signaling pathway	33/1041	122/7206	0.00022695190967
ko04260	Cardiac muscle contraction	28/1041	98/7206	0.000238293796377
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	24/1041	79/7206	0.000268145951818
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1041	59/7206	0.00050973949158
ko04014	Ras signaling pathway	61/1041	279/7206	0.000657843380499
ko05164	Influenza A	10/1041	167/7206	0.00076892665087
ko04621	NOD-like receptor signaling pathway	9/1041	157/7206	0.000789625539786
ko04610	Complement and coagulation cascades	2/1041	79/7206	0.000984674137109
ko03008	Ribosome biogenesis in eukaryotes	2/1041	79/7206	0.000984674137109
ko04918	Thyroid hormone synthesis	24/1041	86/7206	0.000998412799752
ko04146	Peroxisome	3/1041	89/7206	0.00118144998586
ko05168	Herpes simplex infection	12/1041	182/7206	0.00126251251208
ko04930	Type II diabetes mellitus	17/1041	54/7206	0.0013065678365
ko04922	Glucagon signaling pathway	32/1041	128/7206	0.00136153641438
ko04371	Apelin signaling pathway	41/1041	177/7206	0.00158506037641
ko05110	Vibrio cholerae infection	19/1041	63/7206	0.00162924550201
ko05169	Epstein-Barr virus infection	15/1041	206/7206	0.00176422070598
ko04626	Plant-pathogen interaction	8/1041	18/7206	0.00209710858705
ko04270	Vascular smooth muscle contraction	36/1041	154/7206	0.00248299980779
ko03320	PPAR signaling pathway	2/1041	69/7206	0.00294197970052
ko04114	Oocyte meiosis	33/1041	139/7206	0.00317299899454
ko05231	Choline metabolism in cancer	32/1041	134/7206	0.00392812474974
ko00240	Pyrimidine metabolism	6/1041	110/7206	0.00394884933581
ko05034	Alcoholism	50/1041	238/7206	0.0048158554897
ko00590	Arachidonic acid metabolism	1/1041	52/7206	0.00484766414526
ko05162	Measles	7/1041	120/7206	0.00543420344068
ko00562	Inositol phosphate metabolism	23/1041	89/7206	0.00555240396111
ko04964	Proximal tubule bicarbonate reclamation	10/1041	29/7206	0.00557093310677
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1041	100/7206	0.00579333925297
ko04722	Neurotrophin signaling pathway	36/1041	160/7206	0.00594933518676
ko04064	NF-kappa B signaling pathway	5/1041	96/7206	0.00772865094538
ko04923	Regulation of lipolysis in adipocytes	20/1041	77/7206	0.00802414050135
ko04966	Collecting duct acid secretion	9/1041	26/7206	0.00818733065943
ko04630	Jak-STAT signaling pathway	9/1041	132/7206	0.00854970240454
ko05214	Glioma	20/1041	79/7206	0.00938350135872
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1041	14/7206	0.00952661460098
ko04976	Bile secretion	20/1041	80/7206	0.0103005307701
ko03420	Nucleotide excision repair	1/1041	46/7206	0.0107388987353
ko04960	Aldosterone-regulated sodium reabsorption	12/1041	41/7206	0.0124305841953
ko04213	Longevity regulating pathway - multiple species	21/1041	86/7206	0.0127286918204
ko05010	Alzheimer's disease	42/1041	202/7206	0.0143171924939
ko04015	Rap1 signaling pathway	55/1041	278/7206	0.0144757193201
ko04916	Melanogenesis	31/1041	142/7206	0.015480473401
ko03022	Basal transcription factors	1/1041	44/7206	0.0161129443609
ko00071	Fatty acid degradation	1/1041	45/7206	0.0166817399699
ko04012	ErbB signaling pathway	25/1041	109/7206	0.0184614635074
ko05321	Inflammatory bowel disease (IBD)	2/1041	56/7206	0.0197032823689
ko04640	Hematopoietic cell lineage	3/1041	64/7206	0.0199735713912
ko04071	Sphingolipid signaling pathway	34/1041	162/7206	0.0230389648327
ko04350	TGF-beta signaling pathway	7/1041	103/7206	0.0233575128157
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1041	40/7206	0.0236697049367
ko00140	Steroid hormone biosynthesis	1/1041	41/7206	0.0238210443949
ko05230	Central carbon metabolism in cancer	19/1041	81/7206	0.0257581646598
ko04120	Ubiquitin mediated proteolysis	11/1041	138/7206	0.027296216354
ko00310	Lysine degradation	4/1041	73/7206	0.0280483309271
ko00330	Arginine and proline metabolism	3/1041	61/7206	0.0280862417334
ko04330	Notch signaling pathway	3/1041	62/7206	0.0281649005948
ko04622	RIG-I-like receptor signaling pathway	3/1041	62/7206	0.0281649005948
ko04115	p53 signaling pathway	4/1041	74/7206	0.0287079711515
ko00230	Purine metabolism	39/1041	194/7206	0.0291360275229
ko05016	Huntington's disease	20/1041	215/7206	0.0297863601394
ko04062	Chemokine signaling pathway	40/1041	201/7206	0.0320331896874
ko05222	Small cell lung cancer	6/1041	89/7206	0.0336883754474
ko00982	Drug metabolism - cytochrome P450	1/1041	37/7206	0.0350442108401
ko00630	Glyoxylate and dicarboxylate metabolism	1/1041	38/7206	0.0351660145204
ko03410	Base excision repair	1/1041	38/7206	0.0351660145204
ko00260	Glycine, serine and threonine metabolism	2/1041	48/7206	0.0387247262227
ko04973	Carbohydrate digestion and absorption	11/1041	42/7206	0.043800733571
ko04657	IL-17 signaling pathway	6/1041	87/7206	0.0450790859318
ko04142	Lysosome	13/1041	151/7206	0.0456169116642