ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	135/821	423/7206	7.2443851323e-32
ko05033	Nicotine addiction	41/821	56/7206	2.56866397438e-27
ko04724	Glutamatergic synapse	68/821	152/7206	8.49253469489e-26
ko04727	GABAergic synapse	46/821	110/7206	2.2232961964e-16
ko05032	Morphine addiction	46/821	110/7206	2.2232961964e-16
ko04713	Circadian entrainment	52/821	136/7206	2.31146673718e-16
ko04723	Retrograde endocannabinoid signaling	58/821	175/7206	8.01987741948e-15
ko04024	cAMP signaling pathway	77/821	279/7206	2.59106486962e-14
ko04725	Cholinergic synapse	54/821	160/7206	2.98202853346e-14
ko04921	Oxytocin signaling pathway	62/821	209/7206	2.89326397835e-13
ko04728	Dopaminergic synapse	56/821	185/7206	1.72502729575e-12
ko04020	Calcium signaling pathway	66/821	265/7206	3.27954682241e-10
ko04911	Insulin secretion	38/821	117/7206	7.55518482335e-10
ko04721	Synaptic vesicle cycle	30/821	80/7206	9.81229561523e-10
ko04720	Long-term potentiation	34/821	99/7206	1.14372562144e-09
ko05031	Amphetamine addiction	32/821	91/7206	1.80024715116e-09
ko04742	Taste transduction	23/821	61/7206	8.00696215015e-08
ko04726	Serotonergic synapse	38/821	137/7206	1.49396758173e-07
ko04261	Adrenergic signaling in cardiomyocytes	49/821	205/7206	2.79487706063e-07
ko03040	Spliceosome	1/821	145/7206	8.75293416826e-07
ko05203	Viral carcinogenesis	9/821	277/7206	1.01357745129e-06
ko05030	Cocaine addiction	23/821	73/7206	3.16531484237e-06
ko03010	Ribosome	1/821	129/7206	4.23493584839e-06
ko04022	cGMP-PKG signaling pathway	47/821	216/7206	9.61184158623e-06
ko04730	Long-term depression	23/821	78/7206	1.0987342216e-05
ko04970	Salivary secretion	26/821	95/7206	1.32939928409e-05
ko04925	Aldosterone synthesis and secretion	28/821	105/7206	1.3460758651e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	22/821	74/7206	1.47315569453e-05
ko04744	Phototransduction	14/821	36/7206	1.89560274182e-05
ko04072	Phospholipase D signaling pathway	43/821	197/7206	1.945813225e-05
ko05322	Systemic lupus erythematosus	3/821	151/7206	2.43732645326e-05
ko04070	Phosphatidylinositol signaling system	28/821	112/7206	5.73267666764e-05
ko04514	Cell adhesion molecules (CAMs)	31/821	130/7206	6.19548500245e-05
ko04971	Gastric acid secretion	25/821	98/7206	7.67512119321e-05
ko04010	MAPK signaling pathway	60/821	321/7206	9.60004526498e-05
ko05164	Influenza A	5/821	167/7206	0.000111484646051
ko03013	RNA transport	5/821	166/7206	0.000163001953549
ko04745	Phototransduction - fly	13/821	38/7206	0.000175959258457
ko04110	Cell cycle	4/821	145/7206	0.000284221440094
ko04740	Olfactory transduction	20/821	80/7206	0.000544427410931
ko04710	Circadian rhythm	13/821	43/7206	0.000691639157242
ko04060	Cytokine-cytokine receptor interaction	8/821	191/7206	0.000709404998486
ko03008	Ribosome biogenesis in eukaryotes	1/821	79/7206	0.00116193328905
ko05168	Herpes simplex infection	8/821	182/7206	0.0012933597136
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	19/821	79/7206	0.00186201776123
ko04972	Pancreatic secretion	24/821	111/7206	0.00214942680127
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/821	14/7206	0.00287539981033
ko04540	Gap junction	26/821	128/7206	0.0028856145195
ko05162	Measles	4/821	120/7206	0.00324526145796
ko04750	Inflammatory mediator regulation of TRP channels	25/821	122/7206	0.00351623477819
ko04260	Cardiac muscle contraction	21/821	98/7206	0.00354420579636
ko05169	Epstein-Barr virus infection	11/821	206/7206	0.00362827566864
ko04930	Type II diabetes mellitus	13/821	54/7206	0.00783957869326
ko04924	Renin secretion	18/821	86/7206	0.0093996985088
ko05414	Dilated cardiomyopathy	22/821	112/7206	0.00993876824983
ko02010	ABC transporters	10/821	39/7206	0.010162045626
ko05410	Hypertrophic cardiomyopathy (HCM)	20/821	100/7206	0.0104916280497
ko05166	HTLV-I infection	20/821	292/7206	0.0108786373995
ko00680	Methane metabolism	9/821	34/7206	0.0116820204795
ko04626	Plant-pathogen interaction	6/821	18/7206	0.0119297966599
ko04214	Apoptosis - fly	2/821	72/7206	0.0145588151048
ko05161	Hepatitis B	10/821	173/7206	0.0151733517752
ko04014	Ras signaling pathway	45/821	279/7206	0.0158110653109
ko05215	Prostate cancer	5/821	111/7206	0.0158757884262
ko00562	Inositol phosphate metabolism	18/821	89/7206	0.0169413833526
ko04915	Estrogen signaling pathway	24/821	131/7206	0.0174287963914
ko00520	Amino sugar and nucleotide sugar metabolism	1/821	55/7206	0.0177718420076
ko04141	Protein processing in endoplasmic reticulum	11/821	184/7206	0.018058643777
ko04360	Axon guidance	38/821	233/7206	0.0207417505847
ko03320	PPAR signaling pathway	2/821	69/7206	0.0208937605165
ko04621	NOD-like receptor signaling pathway	9/821	157/7206	0.021660848507
ko04371	Apelin signaling pathway	30/821	177/7206	0.0226679757566
ko00650	Butanoate metabolism	7/821	26/7206	0.0229072414625
ko04922	Glucagon signaling pathway	23/821	128/7206	0.0240117647137
ko00010	Glycolysis / Gluconeogenesis	15/821	74/7206	0.0250479993136
ko04640	Hematopoietic cell lineage	2/821	64/7206	0.0296287490757
ko04923	Regulation of lipolysis in adipocytes	15/821	77/7206	0.0305767816898
ko05205	Proteoglycans in cancer	20/821	271/7206	0.0319498213032
ko04142	Lysosome	9/821	151/7206	0.0370537375253
ko01230	Biosynthesis of amino acids	16/821	85/7206	0.0381617539768
ko05219	Bladder cancer	1/821	48/7206	0.0382355740949
ko05231	Choline metabolism in cancer	23/821	134/7206	0.0392789057517
ko04350	TGF-beta signaling pathway	5/821	103/7206	0.0402300540269
ko00512	Mucin type O-glycan biosynthesis	7/821	29/7206	0.0402836063614
ko04964	Proximal tubule bicarbonate reclamation	7/821	29/7206	0.0402836063614
ko04120	Ubiquitin mediated proteolysis	8/821	138/7206	0.0409640059619
ko04114	Oocyte meiosis	24/821	139/7206	0.041568481938
ko04330	Notch signaling pathway	2/821	62/7206	0.0423913937686
ko05140	Leishmaniasis	3/821	75/7206	0.0428000700821