ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko05033	Nicotine addiction	42/805	56/7206	4.9560270669e-29
ko04724	Glutamatergic synapse	71/805	152/7206	6.72382273848e-29
ko04080	Neuroactive ligand-receptor interaction	117/805	423/7206	2.98937763164e-22
ko04727	GABAergic synapse	51/805	110/7206	7.80962570844e-21
ko05032	Morphine addiction	49/805	110/7206	3.88037758405e-19
ko04723	Retrograde endocannabinoid signaling	61/805	175/7206	3.86797661519e-17
ko04728	Dopaminergic synapse	63/805	185/7206	4.32412996511e-17
ko04744	Phototransduction	25/805	36/7206	2.03709201996e-16
ko04713	Circadian entrainment	50/805	136/7206	2.54912178944e-15
ko04725	Cholinergic synapse	51/805	160/7206	9.14180096512e-13
ko04721	Synaptic vesicle cycle	33/805	80/7206	3.80700651732e-12
ko04024	cAMP signaling pathway	68/805	279/7206	1.88055535897e-10
ko04726	Serotonergic synapse	41/805	137/7206	1.43025525727e-09
ko04911	Insulin secretion	37/805	117/7206	1.68571624339e-09
ko04742	Taste transduction	24/805	61/7206	1.06080464256e-08
ko04261	Adrenergic signaling in cardiomyocytes	50/805	205/7206	5.50901662539e-08
ko04514	Cell adhesion molecules (CAMs)	36/805	130/7206	1.32659038006e-07
ko04020	Calcium signaling pathway	59/805	265/7206	1.33957322489e-07
ko05030	Cocaine addiction	25/805	73/7206	1.34004488622e-07
ko05031	Amphetamine addiction	28/805	91/7206	3.13130395674e-07
ko05203	Viral carcinogenesis	8/805	277/7206	4.5789953826e-07
ko03040	Spliceosome	1/805	145/7206	8.52561049357e-07
ko04921	Oxytocin signaling pathway	48/805	209/7206	9.24414180023e-07
ko04720	Long-term potentiation	27/805	99/7206	6.75436379466e-06
ko04970	Salivary secretion	25/805	95/7206	4.07281795388e-05
ko03013	RNA transport	4/805	166/7206	4.78255722908e-05
ko04010	MAPK signaling pathway	59/805	321/7206	8.59677534814e-05
ko05205	Proteoglycans in cancer	12/805	271/7206	0.000108346113217
ko05014	Amyotrophic lateral sclerosis (ALS)	20/805	74/7206	0.000119523604247
ko05164	Influenza A	5/805	167/7206	0.00016011401464
ko05322	Systemic lupus erythematosus	4/805	151/7206	0.000199624544793
ko04110	Cell cycle	4/805	145/7206	0.00027971121459
ko04730	Long-term depression	20/805	78/7206	0.000352568437902
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	20/805	79/7206	0.000394668280488
ko04925	Aldosterone synthesis and secretion	24/805	105/7206	0.000486749088546
ko04260	Cardiac muscle contraction	23/805	98/7206	0.000493074143272
ko05162	Measles	3/805	120/7206	0.000683417312246
ko04072	Phospholipase D signaling pathway	38/805	197/7206	0.000761334594706
ko04060	Cytokine-cytokine receptor interaction	8/805	191/7206	0.000979311187707
ko04740	Olfactory transduction	19/805	80/7206	0.00109776558153
ko04022	cGMP-PKG signaling pathway	40/805	216/7206	0.00131405347814
ko04070	Phosphatidylinositol signaling system	24/805	112/7206	0.00134036433771
ko05168	Herpes simplex infection	8/805	182/7206	0.00177571945061
ko00562	Inositol phosphate metabolism	20/805	89/7206	0.00189281833714
ko04120	Ubiquitin mediated proteolysis	5/805	138/7206	0.00239230246289
ko04360	Axon guidance	41/805	233/7206	0.00287908807415
ko04141	Protein processing in endoplasmic reticulum	9/805	184/7206	0.0041532439204
ko04621	NOD-like receptor signaling pathway	7/805	157/7206	0.00450085352049
ko04630	Jak-STAT signaling pathway	5/805	132/7206	0.00470732860286
ko05169	Epstein-Barr virus infection	11/805	206/7206	0.0048144096173
ko04972	Pancreatic secretion	22/805	111/7206	0.00604976701978
ko04710	Circadian rhythm	11/805	43/7206	0.00630383939504
ko04612	Antigen processing and presentation	2/805	77/7206	0.0102427627793
ko04964	Proximal tubule bicarbonate reclamation	8/805	29/7206	0.0118330506314
ko00330	Arginine and proline metabolism	1/805	61/7206	0.0124416754081
ko00604	Glycosphingolipid biosynthesis - ganglio series	5/805	14/7206	0.0145255660815
ko05140	Leishmaniasis	2/805	75/7206	0.0149519334267
ko04930	Type II diabetes mellitus	12/805	54/7206	0.0158502741292
ko05166	HTLV-I infection	20/805	292/7206	0.0172427296501
ko05161	Hepatitis B	10/805	173/7206	0.0198570751077
ko00240	Pyrimidine metabolism	5/805	110/7206	0.0216735540623
ko04973	Carbohydrate digestion and absorption	10/805	42/7206	0.0219233515087
ko04064	NF-kappa B signaling pathway	4/805	96/7206	0.0222937480101
ko04932	Non-alcoholic fatty liver disease (NAFLD)	11/805	182/7206	0.0232292678517
ko04014	Ras signaling pathway	43/805	279/7206	0.0256180135088
ko00480	Glutathione metabolism	1/805	55/7206	0.02791078282
ko04137	Mitophagy - animal	3/805	82/7206	0.0319232776981
ko04745	Phototransduction - fly	9/805	38/7206	0.0323511864515
ko04971	Gastric acid secretion	18/805	98/7206	0.0337667271283
ko04961	Endocrine and other factor-regulated calcium reabsorption	12/805	59/7206	0.0352984803975
ko05034	Alcoholism	37/805	238/7206	0.0357763039105
ko04924	Renin secretion	16/805	86/7206	0.0370512921566
ko04978	Mineral absorption	9/805	40/7206	0.0379814728147
ko00260	Glycine, serine and threonine metabolism	1/805	48/7206	0.0383357931178
ko05219	Bladder cancer	1/805	48/7206	0.0383357931178
ko00380	Tryptophan metabolism	1/805	50/7206	0.0391206047706
ko04146	Peroxisome	4/805	89/7206	0.0415929534717
ko04913	Ovarian steroidogenesis	2/805	63/7206	0.0425119799729
ko04611	Platelet activation	10/805	163/7206	0.042955489697
ko04711	Circadian rhythm - fly	4/805	13/7206	0.0485224989216
ko04915	Estrogen signaling pathway	22/805	131/7206	0.0487350180766