ko pathway ratio_in_study ratio_in_pop p_value ko04610 Complement and coagulation cascades 34/379 79/7206 2.2373456521e-23 ko04976 Bile secretion 21/379 80/7206 4.59643416428e-10 ko04974 Protein digestion and absorption 22/379 96/7206 2.9119411476e-09 ko00983 Drug metabolism - other enzymes 13/379 42/7206 1.21648448593e-07 ko04977 Vitamin digestion and absorption 9/379 22/7206 7.56818162948e-07 ko00380 Tryptophan metabolism 13/379 50/7206 1.15079438141e-06 ko04614 Renin-angiotensin system 8/379 18/7206 1.49551368584e-06 ko05166 HTLV-I infection 1/379 292/7206 3.03463395241e-06 ko00350 Tyrosine metabolism 10/379 33/7206 4.48092440626e-06 ko00643 Styrene degradation 4/379 4/7206 7.53780404271e-06 ko04975 Fat digestion and absorption 10/379 35/7206 8.08377742072e-06 ko00340 Histidine metabolism 8/379 25/7206 2.66796210255e-05 ko04978 Mineral absorption 10/379 40/7206 2.94628794411e-05 ko00140 Steroid hormone biosynthesis 10/379 41/7206 3.71683891033e-05 ko00830 Retinol metabolism 10/379 42/7206 4.65326266737e-05 ko05150 Staphylococcus aureus infection 9/379 36/7206 7.4188840284e-05 ko00053 Ascorbate and aldarate metabolism 7/379 22/7206 9.02655355688e-05 ko02010 ABC transporters 9/379 39/7206 0.000145121538186 ko05204 Chemical carcinogenesis 10/379 48/7206 0.000155855415892 ko00260 Glycine, serine and threonine metabolism 10/379 48/7206 0.000155855415892 ko00980 Metabolism of xenobiotics by cytochrome P450 9/379 40/7206 0.000178699858466 ko04973 Carbohydrate digestion and absorption 9/379 42/7206 0.000265407299919 ko00120 Primary bile acid biosynthesis 6/379 20/7206 0.000419898124423 ko00982 Drug metabolism - cytochrome P450 8/379 37/7206 0.000546255472305 ko04950 Maturity onset diabetes of the young 7/379 29/7206 0.00059999851479 ko04972 Pancreatic secretion 15/379 111/7206 0.000653967936781 ko03320 PPAR signaling pathway 11/379 69/7206 0.000852981780044 ko04310 Wnt signaling pathway 1/379 181/7206 0.00106615910248 ko00232 Caffeine metabolism 3/379 5/7206 0.00133329855432 ko05203 Viral carcinogenesis 4/379 277/7206 0.00143007462587 ko00360 Phenylalanine metabolism 5/379 17/7206 0.00143338540456 ko00040 Pentose and glucuronate interconversions 6/379 26/7206 0.00190723072769 ko00410 beta-Alanine metabolism 7/379 35/7206 0.00196813441578 ko00500 Starch and sucrose metabolism 7/379 35/7206 0.00196813441578 ko05010 Alzheimer's disease 2/379 202/7206 0.00210860718529 ko05200 Pathways in cancer 12/379 492/7206 0.00225715485027 ko04550 Signaling pathways regulating pluripotency of stem cells 1/379 165/7206 0.00226423298034 ko04360 Axon guidance 3/379 233/7206 0.00252269341897 ko05034 Alcoholism 3/379 238/7206 0.00264924656011 ko04010 MAPK signaling pathway 6/379 321/7206 0.00297603203227 ko00250 Alanine, aspartate and glutamate metabolism 7/379 38/7206 0.0032246401453 ko00100 Steroid biosynthesis 5/379 21/7206 0.00396117374123 ko04144 Endocytosis 7/379 342/7206 0.00397831030521 ko00591 Linoleic acid metabolism 5/379 22/7206 0.00490886673075 ko04217 Necroptosis 2/379 178/7206 0.0061260931961 ko04141 Protein processing in endoplasmic reticulum 2/379 184/7206 0.00637710347193 ko00480 Glutathione metabolism 8/379 55/7206 0.00754632485221 ko04740 Olfactory transduction 10/379 80/7206 0.00878793816787 ko00620 Pyruvate metabolism 7/379 46/7206 0.00953825287165 ko05169 Epstein-Barr virus infection 3/379 206/7206 0.0100590810842 ko00630 Glyoxylate and dicarboxylate metabolism 6/379 38/7206 0.0134433366055 ko00330 Arginine and proline metabolism 8/379 61/7206 0.0138962912424 ko00130 Ubiquinone and other terpenoid-quinone biosynthesis 3/379 11/7206 0.0173625846799 ko00590 Arachidonic acid metabolism 7/379 52/7206 0.0182278853777 ko05162 Measles 1/379 120/7206 0.0213335850261 ko04668 TNF signaling pathway 1/379 120/7206 0.0213335850261 ko00280 Valine, leucine and isoleucine degradation 7/379 54/7206 0.0220722655499 ko04660 T cell receptor signaling pathway 1/379 124/7206 0.022379573156 ko00520 Amino sugar and nucleotide sugar metabolism 7/379 55/7206 0.0241906319015 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/379 5/7206 0.0248167200636 ko04218 Cellular senescence 3/379 177/7206 0.0257462262102 ko04146 Peroxisome 10/379 89/7206 0.025817771948 ko00052 Galactose metabolism 5/379 33/7206 0.0275867105475 ko00071 Fatty acid degradation 6/379 45/7206 0.0291950196332 ko00860 Porphyrin and chlorophyll metabolism 5/379 34/7206 0.0309961990833 ko00770 Pantothenate and CoA biosynthesis 3/379 14/7206 0.0340794201575 ko04114 Oocyte meiosis 2/379 139/7206 0.0343609931225 ko00270 Cysteine and methionine metabolism 6/379 47/7206 0.0352792898061 ko00362 Benzoate degradation 2/379 6/7206 0.035943707175 ko05161 Hepatitis B 3/379 173/7206 0.0361278818546 ko05224 Breast cancer 3/379 174/7206 0.0364617003098 ko04015 Rap1 signaling pathway 7/379 278/7206 0.0383780722389 ko04744 Phototransduction 5/379 36/7206 0.038578293695 ko04024 cAMP signaling pathway 7/379 279/7206 0.0385842524996 ko01230 Biosynthesis of amino acids 9/379 85/7206 0.0436275360435 ko04350 TGF-beta signaling pathway 1/379 103/7206 0.0440060722799 ko04520 Adherens junction 1/379 103/7206 0.0440060722799 ko04922 Glucagon signaling pathway 12/379 128/7206 0.0440974122619 ko04659 Th17 cell differentiation 1/379 106/7206 0.0447868184525 ko00650 Butanoate metabolism 4/379 26/7206 0.0450076642628 ko04924 Renin secretion 9/379 86/7206 0.0453776683773 ko04913 Ovarian steroidogenesis 7/379 63/7206 0.0462841230163 ko00561 Glycerolipid metabolism 7/379 63/7206 0.0462841230163 ko04722 Neurotrophin signaling pathway 3/379 160/7206 0.048431836959 ko00981 Insect hormone biosynthesis 2/379 7/7206 0.0485969460179