ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	195/1199	423/7206	7.94419304153e-49
ko04724	Glutamatergic synapse	92/1199	152/7206	5.90480267328e-35
ko05033	Nicotine addiction	48/1199	56/7206	6.6810264683e-30
ko05032	Morphine addiction	70/1199	110/7206	9.80236306065e-29
ko04713	Circadian entrainment	76/1199	136/7206	7.47269246382e-26
ko04727	GABAergic synapse	66/1199	110/7206	5.22055290172e-25
ko04725	Cholinergic synapse	78/1199	160/7206	1.66967099622e-21
ko04721	Synaptic vesicle cycle	51/1199	80/7206	2.78623465728e-21
ko04728	Dopaminergic synapse	84/1199	185/7206	1.57100027556e-20
ko04723	Retrograde endocannabinoid signaling	78/1199	175/7206	1.52712119387e-18
ko04024	cAMP signaling pathway	106/1199	279/7206	2.90404007023e-18
ko04020	Calcium signaling pathway	97/1199	265/7206	1.20309329623e-15
ko04911	Insulin secretion	56/1199	117/7206	2.59441832768e-15
ko04742	Taste transduction	37/1199	61/7206	9.16167482981e-15
ko04726	Serotonergic synapse	60/1199	137/7206	4.16440539621e-14
ko04744	Phototransduction	26/1199	36/7206	2.05380579216e-13
ko04921	Oxytocin signaling pathway	78/1199	209/7206	2.49443790772e-13
ko05031	Amphetamine addiction	43/1199	91/7206	8.08225987813e-12
ko04720	Long-term potentiation	45/1199	99/7206	1.40928726734e-11
ko04261	Adrenergic signaling in cardiomyocytes	69/1199	205/7206	1.50891776534e-09
ko03010	Ribosome	1/1199	129/7206	2.51216492361e-09
ko03040	Spliceosome	2/1199	145/7206	2.56873085692e-09
ko04970	Salivary secretion	39/1199	95/7206	1.18483030492e-08
ko04925	Aldosterone synthesis and secretion	41/1199	105/7206	3.23666974044e-08
ko04971	Gastric acid secretion	38/1199	98/7206	1.27977792515e-07
ko04360	Axon guidance	70/1199	233/7206	2.32256364187e-07
ko05030	Cocaine addiction	30/1199	73/7206	5.62327020673e-07
ko04621	NOD-like receptor signaling pathway	6/1199	157/7206	7.15574438939e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1199	74/7206	7.97413215429e-07
ko05203	Viral carcinogenesis	19/1199	277/7206	1.42562737878e-06
ko04022	cGMP-PKG signaling pathway	64/1199	216/7206	1.57234260263e-06
ko04740	Olfactory transduction	31/1199	80/7206	2.1138013901e-06
ko05322	Systemic lupus erythematosus	6/1199	151/7206	2.22296159201e-06
ko04966	Collecting duct acid secretion	15/1199	26/7206	2.37013802544e-06
ko05168	Herpes simplex infection	9/1199	182/7206	2.39099663069e-06
ko03013	RNA transport	8/1199	166/7206	4.21595302329e-06
ko04972	Pancreatic secretion	38/1199	111/7206	7.25095997565e-06
ko04060	Cytokine-cytokine receptor interaction	11/1199	191/7206	7.29573103807e-06
ko05164	Influenza A	9/1199	167/7206	1.30865698923e-05
ko04120	Ubiquitin mediated proteolysis	6/1199	138/7206	1.38566400209e-05
ko04010	MAPK signaling pathway	83/1199	321/7206	2.14479870365e-05
ko04110	Cell cycle	7/1199	145/7206	2.26276520722e-05
ko04730	Long-term depression	28/1199	78/7206	3.90955504317e-05
ko04070	Phosphatidylinositol signaling system	36/1199	112/7206	5.12939409762e-05
ko04141	Protein processing in endoplasmic reticulum	12/1199	184/7206	5.22510420433e-05
ko04072	Phospholipase D signaling pathway	55/1199	197/7206	5.80125166795e-05
ko04750	Inflammatory mediator regulation of TRP channels	38/1199	122/7206	6.5227788258e-05
ko04514	Cell adhesion molecules (CAMs)	40/1199	130/7206	6.52685107274e-05
ko04014	Ras signaling pathway	72/1199	279/7206	7.40181077977e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1199	79/7206	0.000112065507923
ko04745	Phototransduction - fly	16/1199	38/7206	0.000178701070499
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1199	79/7206	0.000179769373607
ko04064	NF-kappa B signaling pathway	4/1199	96/7206	0.000271410405881
ko04710	Circadian rhythm	17/1199	43/7206	0.000282213345969
ko04976	Bile secretion	26/1199	80/7206	0.000414237669775
ko04540	Gap junction	37/1199	128/7206	0.000445668148591
ko05110	Vibrio cholerae infection	22/1199	63/7206	0.00045349281816
ko04260	Cardiac muscle contraction	30/1199	98/7206	0.000530583547614
ko05169	Epstein-Barr virus infection	17/1199	206/7206	0.000581851391675
ko04924	Renin secretion	27/1199	86/7206	0.000652802945639
ko05414	Dilated cardiomyopathy	33/1199	112/7206	0.000736737152873
ko04915	Estrogen signaling pathway	37/1199	131/7206	0.00079746892246
ko04612	Antigen processing and presentation	3/1199	77/7206	0.00101882109579
ko04964	Proximal tubule bicarbonate reclamation	12/1199	29/7206	0.00138061903099
ko05140	Leishmaniasis	3/1199	75/7206	0.00150020213728
ko00240	Pyrimidine metabolism	7/1199	110/7206	0.00183852749938
ko05205	Proteoglycans in cancer	27/1199	271/7206	0.00200595785844
ko04973	Carbohydrate digestion and absorption	15/1199	42/7206	0.00262201330201
ko04371	Apelin signaling pathway	45/1199	177/7206	0.00283518199229
ko04923	Regulation of lipolysis in adipocytes	23/1199	77/7206	0.00323026399861
ko04922	Glucagon signaling pathway	34/1199	128/7206	0.00385321598663
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1199	59/7206	0.00408798788678
ko05162	Measles	9/1199	120/7206	0.00433760834675
ko00071	Fatty acid degradation	1/1199	45/7206	0.00434857450098
ko03420	Nucleotide excision repair	1/1199	46/7206	0.0044317761631
ko04015	Rap1 signaling pathway	64/1199	278/7206	0.00509044292284
ko04626	Plant-pathogen interaction	8/1199	18/7206	0.00522488485128
ko04960	Aldosterone-regulated sodium reabsorption	14/1199	41/7206	0.00535415639338
ko03022	Basal transcription factors	1/1199	44/7206	0.00681195647888
ko05161	Hepatitis B	16/1199	173/7206	0.00693812817451
ko05145	Toxoplasmosis	10/1199	126/7206	0.00741201831396
ko04930	Type II diabetes mellitus	17/1199	54/7206	0.0087583444402
ko04330	Notch signaling pathway	3/1199	62/7206	0.00921356080166
ko04622	RIG-I-like receptor signaling pathway	3/1199	62/7206	0.00921356080166
ko04146	Peroxisome	6/1199	89/7206	0.00930741416447
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1199	100/7206	0.00942256713607
ko04610	Complement and coagulation cascades	5/1199	79/7206	0.00950007980176
ko04214	Apoptosis - fly	4/1199	72/7206	0.00984564195078
ko05166	HTLV-I infection	33/1199	292/7206	0.0126202453679
ko04657	IL-17 signaling pathway	6/1199	87/7206	0.0128781834798
ko05133	Pertussis	6/1199	87/7206	0.0128781834798
ko00630	Glyoxylate and dicarboxylate metabolism	1/1199	38/7206	0.0147556031034
ko05219	Bladder cancer	2/1199	48/7206	0.0177341388047
ko05321	Inflammatory bowel disease (IBD)	3/1199	56/7206	0.0184886199342
ko04217	Necroptosis	18/1199	178/7206	0.0185430438403
ko04213	Longevity regulating pathway - multiple species	23/1199	86/7206	0.0185457279738
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1199	14/7206	0.0188233051104
ko00500	Starch and sucrose metabolism	1/1199	35/7206	0.0219693817176
ko05214	Glioma	21/1199	79/7206	0.0222056577827
ko04152	AMPK signaling pathway	38/1199	161/7206	0.0238956979864
ko05131	Shigellosis	6/1199	82/7206	0.0239141209023
ko05144	Malaria	2/1199	45/7206	0.025382147466
ko04210	Apoptosis	19/1199	180/7206	0.0254693892357
ko04912	GnRH signaling pathway	30/1199	122/7206	0.0263179380937
ko00280	Valine, leucine and isoleucine degradation	3/1199	54/7206	0.0263188534217
ko04640	Hematopoietic cell lineage	4/1199	64/7206	0.0265614819702
ko04658	Th1 and Th2 cell differentiation	8/1199	96/7206	0.0265970018236
ko04114	Oocyte meiosis	33/1199	139/7206	0.0284400602734
ko00562	Inositol phosphate metabolism	23/1199	89/7206	0.0302090157615
ko05206	MicroRNAs in cancer	19/1199	177/7206	0.0316802679283
ko04350	TGF-beta signaling pathway	9/1199	103/7206	0.0319330042588
ko04962	Vasopressin-regulated water reabsorption	16/1199	58/7206	0.0324601711045
ko05200	Pathways in cancer	65/1199	492/7206	0.0330897728074
ko04630	Jak-STAT signaling pathway	13/1199	132/7206	0.0334386366043
ko03320	PPAR signaling pathway	5/1199	69/7206	0.0339496518474
ko04062	Chemokine signaling pathway	45/1199	201/7206	0.0339742632404
ko05231	Choline metabolism in cancer	32/1199	134/7206	0.0340832925214
ko04510	Focal adhesion	28/1199	240/7206	0.0343292949163
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1199	92/7206	0.0347105698515
ko01212	Fatty acid metabolism	4/1199	60/7206	0.0358770165696
ko00330	Arginine and proline metabolism	4/1199	61/7206	0.0363825216092
ko00983	Drug metabolism - other enzymes	2/1199	42/7206	0.0364103488325
ko00590	Arachidonic acid metabolism	3/1199	52/7206	0.0375517923697
ko03018	RNA degradation	7/1199	84/7206	0.0386838148592
ko04918	Thyroid hormone synthesis	22/1199	86/7206	0.039761675287
ko05217	Basal cell carcinoma	5/1199	68/7206	0.0474135728299
ko04270	Vascular smooth muscle contraction	35/1199	154/7206	0.048292712022
ko05340	Primary immunodeficiency	1/1199	30/7206	0.0487671910784
ko04211	Longevity regulating pathway	29/1199	123/7206	0.0495140779157