ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 135/871 423/7206 4.35369909473e-29 ko04724 Glutamatergic synapse 73/871 152/7206 2.01810853686e-28 ko05032 Morphine addiction 59/871 110/7206 2.11310756887e-26 ko05033 Nicotine addiction 41/871 56/7206 2.74325992616e-26 ko04727 GABAergic synapse 56/871 110/7206 1.29240529925e-23 ko04713 Circadian entrainment 61/871 136/7206 6.22043851048e-22 ko04728 Dopaminergic synapse 70/871 185/7206 7.00143621277e-20 ko04723 Retrograde endocannabinoid signaling 67/871 175/7206 2.15918905168e-19 ko04725 Cholinergic synapse 60/871 160/7206 5.74209177088e-17 ko04744 Phototransduction 26/871 36/7206 7.57302170013e-17 ko04024 cAMP signaling pathway 84/871 279/7206 2.96803627984e-16 ko04721 Synaptic vesicle cycle 38/871 80/7206 4.06974711896e-15 ko04921 Oxytocin signaling pathway 64/871 209/7206 3.69996619997e-13 ko04726 Serotonergic synapse 48/871 137/7206 1.58673916906e-12 ko04911 Insulin secretion 43/871 117/7206 3.74477162987e-12 ko04742 Taste transduction 29/871 61/7206 7.47710426587e-12 ko04261 Adrenergic signaling in cardiomyocytes 59/871 205/7206 5.77084945184e-11 ko04020 Calcium signaling pathway 69/871 265/7206 2.53794859635e-10 ko05031 Amphetamine addiction 33/871 91/7206 1.8661896215e-09 ko04720 Long-term potentiation 34/871 99/7206 5.43139011011e-09 ko05203 Viral carcinogenesis 9/871 277/7206 2.42010527821e-07 ko04010 MAPK signaling pathway 70/871 321/7206 4.44815165545e-07 ko05030 Cocaine addiction 25/871 73/7206 6.16862094056e-07 ko04060 Cytokine-cytokine receptor interaction 4/871 191/7206 7.40659104379e-07 ko04925 Aldosterone synthesis and secretion 31/871 105/7206 1.19992379147e-06 ko03010 Ribosome 1/871 129/7206 1.75467289629e-06 ko03040 Spliceosome 2/871 145/7206 2.19036788039e-06 ko04070 Phosphatidylinositol signaling system 32/871 112/7206 2.27778823232e-06 ko04970 Salivary secretion 28/871 95/7206 4.07267182185e-06 ko04072 Phospholipase D signaling pathway 46/871 197/7206 6.88801337486e-06 ko04260 Cardiac muscle contraction 27/871 98/7206 2.66847807874e-05 ko04740 Olfactory transduction 23/871 80/7206 4.5289673629e-05 ko05169 Epstein-Barr virus infection 8/871 206/7206 5.07089556701e-05 ko05164 Influenza A 5/871 167/7206 5.43679526499e-05 ko05322 Systemic lupus erythematosus 4/871 151/7206 6.58295158461e-05 ko04745 Phototransduction - fly 14/871 38/7206 7.52191083394e-05 ko04110 Cell cycle 4/871 145/7206 8.97113670186e-05 ko04972 Pancreatic secretion 28/871 111/7206 0.000103931145744 ko04022 cGMP-PKG signaling pathway 46/871 216/7206 0.000110746438706 ko04730 Long-term depression 22/871 78/7206 0.000131370845939 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 22/871 79/7206 0.000147299251293 ko04621 NOD-like receptor signaling pathway 5/871 157/7206 0.000157597880987 ko05168 Herpes simplex infection 7/871 182/7206 0.000185181488094 ko05014 Amyotrophic lateral sclerosis (ALS) 21/871 74/7206 0.000186939404058 ko04971 Gastric acid secretion 25/871 98/7206 0.000227297053739 ko03013 RNA transport 6/871 166/7206 0.00024307127359 ko00562 Inositol phosphate metabolism 23/871 89/7206 0.000397689852639 ko04930 Type II diabetes mellitus 16/871 54/7206 0.000441031073768 ko04966 Collecting duct acid secretion 10/871 26/7206 0.000542888745998 ko04514 Cell adhesion molecules (CAMs) 29/871 130/7206 0.000934253814755 ko04612 Antigen processing and presentation 1/871 77/7206 0.00115930472205 ko04014 Ras signaling pathway 52/871 279/7206 0.00134003018167 ko05162 Measles 4/871 120/7206 0.00158396963372 ko05414 Dilated cardiomyopathy 25/871 112/7206 0.00191175423125 ko04350 TGF-beta signaling pathway 3/871 103/7206 0.00194873514176 ko04915 Estrogen signaling pathway 28/871 131/7206 0.00254208577589 ko05161 Hepatitis B 9/871 173/7206 0.00297885769181 ko04120 Ubiquitin mediated proteolysis 6/871 138/7206 0.00331225974747 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/871 14/7206 0.00389633125741 ko04064 NF-kappa B signaling pathway 3/871 96/7206 0.00394256190456 ko03008 Ribosome biogenesis in eukaryotes 2/871 79/7206 0.00479806111922 ko05140 Leishmaniasis 2/871 75/7206 0.00688149559946 ko04750 Inflammatory mediator regulation of TRP channels 25/871 122/7206 0.00719691161386 ko04360 Axon guidance 42/871 233/7206 0.00754636743394 ko05205 Proteoglycans in cancer 19/871 271/7206 0.00756817375968 ko05166 HTLV-I infection 21/871 292/7206 0.00761448059403 ko05110 Vibrio cholerae infection 15/871 63/7206 0.00970277495823 ko05215 Prostate cancer 5/871 111/7206 0.0116184396549 ko00480 Glutathione metabolism 1/871 55/7206 0.0117686309971 ko05410 Hypertrophic cardiomyopathy (HCM) 21/871 100/7206 0.0121735252336 ko05217 Basal cell carcinoma 2/871 68/7206 0.0142162182759 ko04550 Signaling pathways regulating pluripotency of stem cells 10/871 165/7206 0.0149981727111 ko05231 Choline metabolism in cancer 26/871 134/7206 0.0150372221046 ko04710 Circadian rhythm 11/871 43/7206 0.0151378992695 ko04510 Focal adhesion 17/871 240/7206 0.0151512531308 ko04141 Protein processing in endoplasmic reticulum 12/871 184/7206 0.015903283221 ko00680 Methane metabolism 9/871 34/7206 0.0168536927019 ko04924 Renin secretion 18/871 86/7206 0.0183205818994 ko04964 Proximal tubule bicarbonate reclamation 8/871 29/7206 0.0185452281431 ko04371 Apelin signaling pathway 32/871 177/7206 0.018844417751 ko05034 Alcoholism 41/871 238/7206 0.0194259563573 ko04640 Hematopoietic cell lineage 2/871 64/7206 0.0203403944736 ko05130 Pathogenic Escherichia coli infection 3/871 77/7206 0.0215648253067 ko05219 Bladder cancer 1/871 48/7206 0.0254859677191 ko04330 Notch signaling pathway 2/871 62/7206 0.0293238530262 ko04973 Carbohydrate digestion and absorption 10/871 42/7206 0.0294908517688 ko04657 IL-17 signaling pathway 4/871 87/7206 0.0299814556278 ko05016 Huntington's disease 16/871 215/7206 0.0332270888679 ko04062 Chemokine signaling pathway 34/871 201/7206 0.0370730280369 ko04976 Bile secretion 16/871 80/7206 0.0372370978887 ko05200 Pathways in cancer 45/871 492/7206 0.0376678610749 ko03420 Nucleotide excision repair 1/871 46/7206 0.0379799562398 ko05131 Shigellosis 4/871 82/7206 0.040639247344 ko05206 MicroRNAs in cancer 13/871 177/7206 0.0474647436702 ko04666 Fc gamma R-mediated phagocytosis 22/871 122/7206 0.0492000419825