ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	192/1013	423/7206	4.12434763389e-59
ko05033	Nicotine addiction	46/1013	56/7206	2.24754817624e-30
ko04724	Glutamatergic synapse	80/1013	152/7206	5.75404377469e-30
ko04713	Circadian entrainment	68/1013	136/7206	6.71917114346e-24
ko04721	Synaptic vesicle cycle	48/1013	80/7206	1.11361612982e-21
ko04728	Dopaminergic synapse	78/1013	185/7206	2.41919834626e-21
ko04727	GABAergic synapse	56/1013	110/7206	2.37111154743e-20
ko05032	Morphine addiction	56/1013	110/7206	2.37111154743e-20
ko04725	Cholinergic synapse	69/1013	160/7206	1.20072582351e-19
ko04020	Calcium signaling pathway	93/1013	265/7206	1.18118638167e-18
ko04024	cAMP signaling pathway	94/1013	279/7206	2.59976780639e-17
ko04723	Retrograde endocannabinoid signaling	68/1013	175/7206	1.70123026285e-16
ko04921	Oxytocin signaling pathway	73/1013	209/7206	1.00623646417e-14
ko04911	Insulin secretion	49/1013	117/7206	1.08660023422e-13
ko04726	Serotonergic synapse	54/1013	137/7206	1.21371830552e-13
ko04742	Taste transduction	32/1013	61/7206	1.2473469164e-12
ko04261	Adrenergic signaling in cardiomyocytes	67/1013	205/7206	5.30577495325e-12
ko05031	Amphetamine addiction	39/1013	91/7206	1.56320490228e-11
ko04720	Long-term potentiation	41/1013	99/7206	1.77778334457e-11
ko04970	Salivary secretion	38/1013	95/7206	3.34466365653e-10
ko03040	Spliceosome	1/1013	145/7206	9.05259771058e-09
ko05203	Viral carcinogenesis	11/1013	277/7206	2.86181652886e-08
ko05030	Cocaine addiction	28/1013	73/7206	2.07351274346e-07
ko04360	Axon guidance	62/1013	233/7206	2.60531076516e-07
ko04744	Phototransduction	18/1013	36/7206	2.93704408638e-07
ko05168	Herpes simplex infection	5/1013	182/7206	3.73983748624e-07
ko05164	Influenza A	4/1013	167/7206	3.92450199386e-07
ko04925	Aldosterone synthesis and secretion	35/1013	105/7206	4.83549812993e-07
ko04740	Olfactory transduction	29/1013	80/7206	5.15829699287e-07
ko04060	Cytokine-cytokine receptor interaction	6/1013	191/7206	7.17562561154e-07
ko04971	Gastric acid secretion	33/1013	98/7206	9.38605948898e-07
ko04010	MAPK signaling pathway	77/1013	321/7206	1.00830454148e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1013	74/7206	1.0965474199e-06
ko04022	cGMP-PKG signaling pathway	57/1013	216/7206	1.23092309563e-06
ko05322	Systemic lupus erythematosus	4/1013	151/7206	2.65840246944e-06
ko04120	Ubiquitin mediated proteolysis	3/1013	138/7206	2.78693808844e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1013	79/7206	4.69500070001e-06
ko04966	Collecting duct acid secretion	13/1013	26/7206	1.36188661967e-05
ko04540	Gap junction	37/1013	128/7206	1.41040732356e-05
ko04730	Long-term depression	26/1013	78/7206	1.86565179562e-05
ko04745	Phototransduction - fly	16/1013	38/7206	2.18734977802e-05
ko04260	Cardiac muscle contraction	30/1013	98/7206	2.2982365759e-05
ko04924	Renin secretion	27/1013	86/7206	2.95901361089e-05
ko04514	Cell adhesion molecules (CAMs)	36/1013	130/7206	3.54126759902e-05
ko04972	Pancreatic secretion	32/1013	111/7206	4.38053400753e-05
ko03013	RNA transport	7/1013	166/7206	5.88150911552e-05
ko05169	Epstein-Barr virus infection	11/1013	206/7206	9.1886561427e-05
ko05414	Dilated cardiomyopathy	31/1013	112/7206	0.000155484125512
ko04072	Phospholipase D signaling pathway	47/1013	197/7206	0.000165718768053
ko04612	Antigen processing and presentation	1/1013	77/7206	0.000197041800471
ko05110	Vibrio cholerae infection	20/1013	63/7206	0.000319474325918
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1013	59/7206	0.000415919393376
ko04621	NOD-like receptor signaling pathway	8/1013	157/7206	0.000433439564952
ko04014	Ras signaling pathway	60/1013	279/7206	0.000565461513685
ko04110	Cell cycle	7/1013	145/7206	0.000612072442707
ko04932	Non-alcoholic fatty liver disease (NAFLD)	11/1013	182/7206	0.000758244889248
ko04141	Protein processing in endoplasmic reticulum	11/1013	184/7206	0.000770601103738
ko04750	Inflammatory mediator regulation of TRP channels	31/1013	122/7206	0.00085011628756
ko03008	Ribosome biogenesis in eukaryotes	2/1013	79/7206	0.000954713813166
ko05205	Proteoglycans in cancer	21/1013	271/7206	0.00171299080904
ko05161	Hepatitis B	11/1013	173/7206	0.00182370264327
ko05162	Measles	6/1013	120/7206	0.00211412274154
ko05140	Leishmaniasis	2/1013	75/7206	0.00212976678863
ko04070	Phosphatidylinositol signaling system	28/1013	112/7206	0.00221332875012
ko04064	NF-kappa B signaling pathway	4/1013	96/7206	0.00274094654311
ko04915	Estrogen signaling pathway	31/1013	131/7206	0.00315782844756
ko04976	Bile secretion	21/1013	80/7206	0.00328536066956
ko05166	HTLV-I infection	25/1013	292/7206	0.00446395502048
ko04964	Proximal tubule bicarbonate reclamation	10/1013	29/7206	0.00456574961903
ko00480	Glutathione metabolism	1/1013	55/7206	0.00517284545956
ko04146	Peroxisome	4/1013	89/7206	0.00538880099348
ko00240	Pyrimidine metabolism	6/1013	110/7206	0.00551794207777
ko04371	Apelin signaling pathway	38/1013	177/7206	0.00601716635051
ko04640	Hematopoietic cell lineage	2/1013	64/7206	0.00631602527958
ko00590	Arachidonic acid metabolism	1/1013	52/7206	0.00766092844084
ko04626	Plant-pathogen interaction	7/1013	18/7206	0.00821968217277
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1013	100/7206	0.00823631423326
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1013	14/7206	0.00832877776448
ko04930	Type II diabetes mellitus	15/1013	54/7206	0.00877970301658
ko04140	Autophagy - animal	12/1013	164/7206	0.00888546094914
ko00330	Arginine and proline metabolism	2/1013	61/7206	0.00915294084823
ko04330	Notch signaling pathway	2/1013	62/7206	0.00919983208157
ko04214	Apoptosis - fly	3/1013	72/7206	0.0101403134658
ko04350	TGF-beta signaling pathway	6/1013	103/7206	0.0142174117612
ko03022	Basal transcription factors	1/1013	44/7206	0.0161951622226
ko05144	Malaria	1/1013	45/7206	0.0162767618461
ko00071	Fatty acid degradation	1/1013	45/7206	0.0162767618461
ko00620	Pyruvate metabolism	1/1013	46/7206	0.0167489415285
ko03420	Nucleotide excision repair	1/1013	46/7206	0.0167489415285
ko04912	GnRH signaling pathway	27/1013	122/7206	0.0170426609674
ko04015	Rap1 signaling pathway	53/1013	278/7206	0.0173397842948
ko05321	Inflammatory bowel disease (IBD)	2/1013	56/7206	0.0191427532931
ko04657	IL-17 signaling pathway	5/1013	87/7206	0.019813340732
ko05418	Fluid shear stress and atherosclerosis	14/1013	173/7206	0.0198331459452
ko01200	Carbon metabolism	9/1013	128/7206	0.0201077260316
ko00983	Drug metabolism - other enzymes	1/1013	42/7206	0.0240747706885
ko03018	RNA degradation	5/1013	84/7206	0.0269649342539
ko01524	Platinum drug resistance	4/1013	76/7206	0.0290126575044
ko04923	Regulation of lipolysis in adipocytes	18/1013	77/7206	0.0300013236275
ko04630	Jak-STAT signaling pathway	10/1013	132/7206	0.0308369514574
ko04668	TNF signaling pathway	9/1013	120/7206	0.0340649392505
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1013	40/7206	0.0364107390281
ko05131	Shigellosis	5/1013	82/7206	0.0366525699673
ko04916	Melanogenesis	29/1013	142/7206	0.0370771493238
ko05212	Pancreatic cancer	5/1013	83/7206	0.0371471377202
ko04722	Neurotrophin signaling pathway	32/1013	160/7206	0.0374852309905
ko05215	Prostate cancer	8/1013	111/7206	0.0379007252847
ko00380	Tryptophan metabolism	2/1013	50/7206	0.0393369551744
ko00310	Lysine degradation	4/1013	73/7206	0.0398860711521
ko04973	Carbohydrate digestion and absorption	11/1013	42/7206	0.0404673087816
ko04622	RIG-I-like receptor signaling pathway	3/1013	62/7206	0.0408580385551
ko04620	Toll-like receptor signaling pathway	7/1013	100/7206	0.0415980238587
ko05120	Epithelial cell signaling in Helicobacter pylori infection	20/1013	92/7206	0.0476731265984
ko04217	Necroptosis	16/1013	178/7206	0.0491432426904