ko pathway ratio_in_study ratio_in_pop p_value ko05033 Nicotine addiction 22/413 56/7206 9.76095778623e-14 ko04360 Axon guidance 42/413 233/7206 1.52816810596e-11 ko04724 Glutamatergic synapse 31/413 152/7206 3.40152151627e-10 ko04728 Dopaminergic synapse 34/413 185/7206 8.68987403159e-10 ko05032 Morphine addiction 25/413 110/7206 1.73787177802e-09 ko04723 Retrograde endocannabinoid signaling 31/413 175/7206 1.24453710286e-08 ko04010 MAPK signaling pathway 45/413 321/7206 1.74131209148e-08 ko04721 Synaptic vesicle cycle 19/413 80/7206 7.63382245163e-08 ko04727 GABAergic synapse 22/413 110/7206 1.93060290095e-07 ko04713 Circadian entrainment 21/413 136/7206 2.69266455328e-05 ko04024 cAMP signaling pathway 34/413 279/7206 2.95293387015e-05 ko04930 Type II diabetes mellitus 12/413 54/7206 4.0681550849e-05 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/413 14/7206 6.92133830694e-05 ko04514 Cell adhesion molecules (CAMs) 19/413 130/7206 0.000138400184824 ko04144 Endocytosis 36/413 342/7206 0.000310984077158 ko05210 Colorectal cancer 14/413 86/7206 0.000337450617383 ko04725 Cholinergic synapse 21/413 160/7206 0.000364804788191 ko04391 Hippo signaling pathway - fly 14/413 90/7206 0.000544934413369 ko04911 Insulin secretion 16/413 117/7206 0.000970946515311 ko03013 RNA transport 1/413 166/7206 0.00104784371567 ko04390 Hippo signaling pathway 22/413 188/7206 0.00121732213979 ko04261 Adrenergic signaling in cardiomyocytes 23/413 205/7206 0.001892752327 ko04921 Oxytocin signaling pathway 23/413 209/7206 0.00223420683614 ko00515 Mannose type O-glycan biosynthesis 6/413 25/7206 0.00238113123143 ko03040 Spliceosome 1/413 145/7206 0.00326579364809 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 11/413 79/7206 0.00508713885199 ko05203 Viral carcinogenesis 6/413 277/7206 0.00542269853318 ko05031 Amphetamine addiction 12/413 91/7206 0.00548192944549 ko04071 Sphingolipid signaling pathway 18/413 162/7206 0.00580542335668 ko04742 Taste transduction 9/413 61/7206 0.00744600616345 ko04726 Serotonergic synapse 16/413 137/7206 0.00769748366441 ko04080 Neuroactive ligand-receptor interaction 37/413 423/7206 0.0092552904515 ko00190 Oxidative phosphorylation 1/413 127/7206 0.0104261542581 ko05142 Chagas disease (American trypanosomiasis) 15/413 130/7206 0.0111428933002 ko04072 Phospholipase D signaling pathway 20/413 197/7206 0.0118481744162 ko05322 Systemic lupus erythematosus 2/413 151/7206 0.0122307046628 ko04014 Ras signaling pathway 26/413 279/7206 0.0122626383713 ko05231 Choline metabolism in cancer 15/413 134/7206 0.0126506743274 ko04260 Cardiac muscle contraction 12/413 98/7206 0.0128019062014 ko04730 Long-term depression 10/413 78/7206 0.0130648879764 ko05410 Hypertrophic cardiomyopathy (HCM) 12/413 100/7206 0.014113184734 ko04917 Prolactin signaling pathway 11/413 87/7206 0.016176444454 ko04550 Signaling pathways regulating pluripotency of stem cells 17/413 165/7206 0.0165812466572 ko00510 N-Glycan biosynthesis 7/413 50/7206 0.0228010873642 ko05012 Parkinson's disease 3/413 155/7206 0.0351211691392 ko04920 Adipocytokine signaling pathway 10/413 89/7206 0.0354006449219 ko05030 Cocaine addiction 9/413 73/7206 0.0360026708703 ko05414 Dilated cardiomyopathy 12/413 112/7206 0.0362860005944 ko05205 Proteoglycans in cancer 8/413 271/7206 0.0447882862225 ko04670 Leukocyte transendothelial migration 3/413 151/7206 0.0489087646192