ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 52/560 191/7206 2.03633627375e-16 ko04621 NOD-like receptor signaling pathway 39/560 157/7206 3.08359262623e-11 ko05164 Influenza A 40/560 167/7206 5.78177481908e-11 ko05340 Primary immunodeficiency 15/560 30/7206 9.8346312229e-10 ko04650 Natural killer cell mediated cytotoxicity 27/560 97/7206 2.48651132763e-09 ko04380 Osteoclast differentiation 32/560 134/7206 5.51102066941e-09 ko04064 NF-kappa B signaling pathway 26/560 96/7206 9.30396421006e-09 ko04620 Toll-like receptor signaling pathway 26/560 100/7206 2.35524850176e-08 ko00120 Primary bile acid biosynthesis 11/560 20/7206 4.98993147772e-08 ko04217 Necroptosis 36/560 178/7206 6.59754570193e-08 ko05321 Inflammatory bowel disease (IBD) 18/560 56/7206 1.0580483598e-07 ko05140 Leishmaniasis 21/560 75/7206 1.3517783403e-07 ko05145 Toxoplasmosis 28/560 126/7206 2.57803182543e-07 ko05162 Measles 27/560 120/7206 3.23916218531e-07 ko05168 Herpes simplex infection 34/560 182/7206 1.42508597364e-06 ko04612 Antigen processing and presentation 19/560 77/7206 4.33833330525e-06 ko05330 Allograft rejection 10/560 24/7206 5.35517537344e-06 ko04062 Chemokine signaling pathway 35/560 201/7206 5.36926673175e-06 ko05150 Staphylococcus aureus infection 12/560 36/7206 9.53127288659e-06 ko04672 Intestinal immune network for IgA production 12/560 37/7206 1.3123392776e-05 ko04622 RIG-I-like receptor signaling pathway 16/560 62/7206 1.3428347606e-05 ko04659 Th17 cell differentiation 22/560 106/7206 1.60362373432e-05 ko04630 Jak-STAT signaling pathway 25/560 132/7206 2.29730624443e-05 ko04660 T cell receptor signaling pathway 24/560 124/7206 2.29777295886e-05 ko04610 Complement and coagulation cascades 18/560 79/7206 2.52241291447e-05 ko05332 Graft-versus-host disease 8/560 18/7206 2.7506623612e-05 ko00590 Arachidonic acid metabolism 14/560 52/7206 2.76673674208e-05 ko04662 B cell receptor signaling pathway 19/560 88/7206 3.386649542e-05 ko05320 Autoimmune thyroid disease 10/560 29/7206 3.82798058908e-05 ko05152 Tuberculosis 31/560 187/7206 4.35395216993e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 31/560 191/7206 8.45046765844e-05 ko05133 Pertussis 18/560 87/7206 9.7995813105e-05 ko05144 Malaria 12/560 45/7206 0.00011446980938 ko04658 Th1 and Th2 cell differentiation 19/560 96/7206 0.000118538591867 ko04146 Peroxisome 18/560 89/7206 0.000133368697566 ko04210 Apoptosis 29/560 180/7206 0.000172619526376 ko04668 TNF signaling pathway 22/560 120/7206 0.0001728940273 ko03040 Spliceosome 1/560 145/7206 0.000211657161983 ko04390 Hippo signaling pathway 3/560 188/7206 0.000281138007622 ko03013 RNA transport 2/560 166/7206 0.000319413432894 ko05323 Rheumatoid arthritis 17/560 89/7206 0.000415995058329 ko05161 Hepatitis B 27/560 173/7206 0.000433930812735 ko03010 Ribosome 1/560 129/7206 0.00066621064092 ko00350 Tyrosine metabolism 9/560 33/7206 0.000686685996845 ko04623 Cytosolic DNA-sensing pathway 10/560 41/7206 0.000914553099317 ko04640 Hematopoietic cell lineage 13/560 64/7206 0.00107282373218 ko05310 Asthma 6/560 17/7206 0.00126245527732 ko05142 Chagas disease (American trypanosomiasis) 21/560 130/7206 0.00127299446491 ko04110 Cell cycle 2/560 145/7206 0.00138447678124 ko04666 Fc gamma R-mediated phagocytosis 20/560 122/7206 0.00160203592224 ko05160 Hepatitis C 23/560 153/7206 0.00193054639997 ko00592 alpha-Linolenic acid metabolism 6/560 19/7206 0.00242038542105 ko04940 Type I diabetes mellitus 8/560 32/7206 0.00249792976275 ko04310 Wnt signaling pathway 4/560 181/7206 0.00270827263165 ko05034 Alcoholism 7/560 238/7206 0.00282872269824 ko00140 Steroid hormone biosynthesis 9/560 41/7206 0.00356696518788 ko05224 Breast cancer 4/560 174/7206 0.00366336707788 ko00983 Drug metabolism - other enzymes 9/560 42/7206 0.00423472082653 ko00051 Fructose and mannose metabolism 9/560 42/7206 0.00423472082653 ko04145 Phagosome 23/560 162/7206 0.00429471771386 ko04611 Platelet activation 23/560 163/7206 0.00450571531369 ko04670 Leukocyte transendothelial migration 22/560 151/7206 0.00490103394461 ko00950 Isoquinoline alkaloid biosynthesis 4/560 10/7206 0.00518710090574 ko04657 IL-17 signaling pathway 14/560 87/7206 0.00760784154086 ko04664 Fc epsilon RI signaling pathway 13/560 77/7206 0.00782422636374 ko00360 Phenylalanine metabolism 5/560 17/7206 0.00784696410782 ko03015 mRNA surveillance pathway 1/560 93/7206 0.00963713784344 ko03320 PPAR signaling pathway 12/560 69/7206 0.00998141158278 ko05131 Shigellosis 13/560 82/7206 0.0113350339809 ko05132 Salmonella infection 15/560 98/7206 0.0114323095146 ko05146 Amoebiasis 15/560 99/7206 0.0120066877478 ko05134 Legionellosis 12/560 74/7206 0.0134775379098 ko01524 Platinum drug resistance 12/560 76/7206 0.0156242400924 ko04740 Olfactory transduction 1/560 80/7206 0.0198533199921 ko04933 AGE-RAGE signaling pathway in diabetic complications 18/560 135/7206 0.0217966986656 ko00982 Drug metabolism - cytochrome P450 7/560 37/7206 0.0218982357797 ko04530 Tight junction 9/560 228/7206 0.0236313218009 ko04360 Axon guidance 9/560 233/7206 0.0240724628812 ko04114 Oocyte meiosis 4/560 139/7206 0.0244400133462 ko04916 Melanogenesis 4/560 142/7206 0.0249488133965 ko04910 Insulin signaling pathway 6/560 172/7206 0.0300139774491 ko05204 Chemical carcinogenesis 8/560 48/7206 0.0300337107948 ko04723 Retrograde endocannabinoid signaling 6/560 175/7206 0.030512981488 ko00980 Metabolism of xenobiotics by cytochrome P450 7/560 40/7206 0.0324588145422 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/560 4/7206 0.0325484021213 ko00643 Styrene degradation 2/560 4/7206 0.0325484021213 ko04137 Mitophagy - animal 12/560 82/7206 0.0338541512869 ko05143 African trypanosomiasis 6/560 32/7206 0.0342106459932 ko04080 Neuroactive ligand-receptor interaction 22/560 423/7206 0.0395204995009 ko00565 Ether lipid metabolism 7/560 42/7206 0.0411238216212