ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 46/581 191/7206 5.89625272095e-12 ko04380 Osteoclast differentiation 35/581 134/7206 2.02706769789e-10 ko04610 Complement and coagulation cascades 22/581 79/7206 1.45362319005e-07 ko04512 ECM-receptor interaction 22/581 79/7206 1.45362319005e-07 ko05034 Alcoholism 3/581 238/7206 4.87103716188e-06 ko04658 Th1 and Th2 cell differentiation 22/581 96/7206 5.32907141931e-06 ko04933 AGE-RAGE signaling pathway in diabetic complications 27/581 135/7206 7.45369745695e-06 ko05150 Staphylococcus aureus infection 12/581 36/7206 1.38984705258e-05 ko04611 Platelet activation 30/581 163/7206 1.43733476698e-05 ko04064 NF-kappa B signaling pathway 21/581 96/7206 1.86950700035e-05 ko04672 Intestinal immune network for IgA production 12/581 37/7206 1.90824077831e-05 ko05321 Inflammatory bowel disease (IBD) 15/581 56/7206 2.38094795766e-05 ko04659 Th17 cell differentiation 22/581 106/7206 2.84947721813e-05 ko04640 Hematopoietic cell lineage 16/581 64/7206 3.27281049895e-05 ko04510 Focal adhesion 38/581 240/7206 5.02391512099e-05 ko04621 NOD-like receptor signaling pathway 28/581 157/7206 7.10992224255e-05 ko04650 Natural killer cell mediated cytotoxicity 20/581 97/7206 7.21321935876e-05 ko05145 Toxoplasmosis 24/581 126/7206 7.78128746356e-05 ko00120 Primary bile acid biosynthesis 8/581 20/7206 8.9581716827e-05 ko00590 Arachidonic acid metabolism 13/581 52/7206 0.000178494420757 ko00350 Tyrosine metabolism 10/581 33/7206 0.000180800733683 ko03013 RNA transport 2/581 166/7206 0.000222549889637 ko05164 Influenza A 28/581 167/7206 0.000230420964461 ko05140 Leishmaniasis 16/581 75/7206 0.000248548659061 ko05146 Amoebiasis 19/581 99/7206 0.000292070779715 ko05340 Primary immunodeficiency 9/581 30/7206 0.000414164290005 ko03010 Ribosome 1/581 129/7206 0.000442508785816 ko04630 Jak-STAT signaling pathway 23/581 132/7206 0.000488682066485 ko04723 Retrograde endocannabinoid signaling 3/581 175/7206 0.000587012489377 ko05144 Malaria 11/581 45/7206 0.000685256351792 ko04728 Dopaminergic synapse 4/581 185/7206 0.000934802822277 ko03040 Spliceosome 2/581 145/7206 0.000951792093911 ko04110 Cell cycle 2/581 145/7206 0.000951792093911 ko00360 Phenylalanine metabolism 6/581 17/7206 0.00153099917764 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 3/581 4/7206 0.00196102852857 ko00643 Styrene degradation 3/581 4/7206 0.00196102852857 ko04666 Fc gamma R-mediated phagocytosis 20/581 122/7206 0.00204062470018 ko04662 B cell receptor signaling pathway 16/581 88/7206 0.00216023731778 ko04660 T cell receptor signaling pathway 20/581 124/7206 0.00235520329121 ko00592 alpha-Linolenic acid metabolism 6/581 19/7206 0.0029201682796 ko05162 Measles 19/581 120/7206 0.00366725189866 ko00140 Steroid hormone biosynthesis 9/581 41/7206 0.00456111061781 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 3/581 5/7206 0.00460874616067 ko05323 Rheumatoid arthritis 15/581 89/7206 0.00518501948702 ko00565 Ether lipid metabolism 9/581 42/7206 0.00540069248523 ko00950 Isoquinoline alkaloid biosynthesis 4/581 10/7206 0.00592457237456 ko03015 mRNA surveillance pathway 1/581 93/7206 0.00638446986752 ko04713 Circadian entrainment 3/581 136/7206 0.0064147075643 ko04114 Oocyte meiosis 3/581 139/7206 0.00660268585757 ko04620 Toll-like receptor signaling pathway 16/581 100/7206 0.00802484208646 ko00071 Fatty acid degradation 9/581 45/7206 0.00864709954747 ko00362 Benzoate degradation 3/581 6/7206 0.00866740326322 ko04111 Cell cycle - yeast 1/581 90/7206 0.00961348864631 ko04810 Regulation of actin cytoskeleton 33/581 264/7206 0.0107785965689 ko03320 PPAR signaling pathway 12/581 69/7206 0.0113529756396 ko04727 GABAergic synapse 2/581 110/7206 0.0118679424801 ko04974 Protein digestion and absorption 15/581 96/7206 0.0122691951839 ko05152 Tuberculosis 25/581 187/7206 0.0132539003413 ko04670 Leukocyte transendothelial migration 21/581 151/7206 0.0142994327016 ko05133 Pertussis 14/581 87/7206 0.0148223904005 ko04710 Circadian rhythm 8/581 43/7206 0.0198412939224 ko04721 Synaptic vesicle cycle 1/581 80/7206 0.0203663420577 ko04740 Olfactory transduction 1/581 80/7206 0.0203663420577 ko05142 Chagas disease (American trypanosomiasis) 18/581 130/7206 0.0215338181451 ko04514 Cell adhesion molecules (CAMs) 18/581 130/7206 0.0215338181451 ko04724 Glutamatergic synapse 5/581 152/7206 0.0235731068784 ko04911 Insulin secretion 3/581 117/7206 0.0244443861464 ko04120 Ubiquitin mediated proteolysis 4/581 138/7206 0.0251846621154 ko04062 Chemokine signaling pathway 25/581 201/7206 0.0253878179482 ko04668 TNF signaling pathway 17/581 120/7206 0.0256228199454 ko05320 Autoimmune thyroid disease 6/581 29/7206 0.0256832600166 ko05168 Herpes simplex infection 23/581 182/7206 0.0269918874973 ko04141 Protein processing in endoplasmic reticulum 7/581 184/7206 0.0277584268543 ko04146 Peroxisome 13/581 89/7206 0.0301270240138 ko05016 Huntington's disease 9/581 215/7206 0.0303873533865 ko04612 Antigen processing and presentation 12/581 77/7206 0.0311794087417 ko05161 Hepatitis B 22/581 173/7206 0.0324439604297 ko05032 Morphine addiction 3/581 110/7206 0.0334455268009 ko04972 Pancreatic secretion 3/581 111/7206 0.0335688336609 ko05160 Hepatitis C 20/581 153/7206 0.0336200561413 ko04270 Vascular smooth muscle contraction 20/581 154/7206 0.0343097314526 ko05132 Salmonella infection 14/581 98/7206 0.0365714627089 ko05131 Shigellosis 12/581 82/7206 0.0386116362083 ko05330 Allograft rejection 5/581 24/7206 0.039432604188 ko05310 Asthma 4/581 17/7206 0.0427674792594 ko04072 Phospholipase D signaling pathway 24/581 197/7206 0.0448640887076