ko pathway ratio_in_study ratio_in_pop p_value ko04380 Osteoclast differentiation 27/255 134/7206 8.7449188225e-14 ko04060 Cytokine-cytokine receptor interaction 28/255 191/7206 9.79767385544e-11 ko04650 Natural killer cell mediated cytotoxicity 19/255 97/7206 8.0990979215e-10 ko04621 NOD-like receptor signaling pathway 24/255 157/7206 9.70556344224e-10 ko04064 NF-kappa B signaling pathway 18/255 96/7206 4.80041009336e-09 ko04660 T cell receptor signaling pathway 20/255 124/7206 1.00512996431e-08 ko04662 B cell receptor signaling pathway 16/255 88/7206 5.57971787177e-08 ko05140 Leishmaniasis 14/255 75/7206 2.74872944204e-07 ko05150 Staphylococcus aureus infection 10/255 36/7206 2.91323524483e-07 ko05340 Primary immunodeficiency 9/255 30/7206 5.63584379086e-07 ko04666 Fc gamma R-mediated phagocytosis 17/255 122/7206 1.15167314217e-06 ko05164 Influenza A 20/255 167/7206 1.52346852707e-06 ko05133 Pertussis 14/255 87/7206 1.81270870024e-06 ko04664 Fc epsilon RI signaling pathway 13/255 77/7206 2.44415665683e-06 ko04630 Jak-STAT signaling pathway 17/255 132/7206 3.50813434384e-06 ko04659 Th17 cell differentiation 15/255 106/7206 4.10102659892e-06 ko05152 Tuberculosis 20/255 187/7206 8.82979342323e-06 ko04610 Complement and coagulation cascades 12/255 79/7206 1.84591908355e-05 ko05162 Measles 15/255 120/7206 1.91939371144e-05 ko04668 TNF signaling pathway 15/255 120/7206 1.91939371144e-05 ko04670 Leukocyte transendothelial migration 17/255 151/7206 2.17148468166e-05 ko04658 Th1 and Th2 cell differentiation 13/255 96/7206 2.94619498145e-05 ko04620 Toll-like receptor signaling pathway 13/255 100/7206 4.57482602681e-05 ko04622 RIG-I-like receptor signaling pathway 10/255 62/7206 5.47031410114e-05 ko04611 Platelet activation 17/255 163/7206 5.84455257462e-05 ko05323 Rheumatoid arthritis 12/255 89/7206 6.24751542309e-05 ko04623 Cytosolic DNA-sensing pathway 8/255 41/7206 7.63256628349e-05 ko05161 Hepatitis B 17/255 173/7206 0.00012326947909 ko05131 Shigellosis 11/255 82/7206 0.000132543161462 ko05145 Toxoplasmosis 14/255 126/7206 0.000134473398459 ko05144 Malaria 8/255 45/7206 0.000152324748594 ko05168 Herpes simplex infection 17/255 182/7206 0.000228678986567 ko05310 Asthma 5/255 17/7206 0.000232751493618 ko04672 Intestinal immune network for IgA production 7/255 37/7206 0.000265052438872 ko04640 Hematopoietic cell lineage 9/255 64/7206 0.000378490517884 ko04217 Necroptosis 16/255 178/7206 0.000536726044726 ko05142 Chagas disease (American trypanosomiasis) 13/255 130/7206 0.00065455985971 ko05321 Inflammatory bowel disease (IBD) 8/255 56/7206 0.000717261150615 ko04062 Chemokine signaling pathway 17/255 201/7206 0.000729808391588 ko05167 Kaposi's sarcoma-associated herpesvirus infection 16/255 191/7206 0.00115362641087 ko05330 Allograft rejection 5/255 24/7206 0.0013048861807 ko04210 Apoptosis 15/255 180/7206 0.00172351499985 ko04657 IL-17 signaling pathway 9/255 87/7206 0.00347876850846 ko05034 Alcoholism 1/255 238/7206 0.00350161870438 ko05134 Legionellosis 8/255 74/7206 0.00440481875997 ko04932 Non-alcoholic fatty liver disease (NAFLD) 14/255 182/7206 0.00633669003022 ko04145 Phagosome 13/255 162/7206 0.00748871779439 ko05132 Salmonella infection 9/255 98/7206 0.0076296825434 ko04933 AGE-RAGE signaling pathway in diabetic complications 11/255 135/7206 0.0081572106561 ko05120 Epithelial cell signaling in Helicobacter pylori infection 8/255 92/7206 0.0158171252282 ko05320 Autoimmune thyroid disease 4/255 29/7206 0.0181306655292 ko05166 HTLV-I infection 18/255 292/7206 0.0217156357997 ko05224 Breast cancer 1/255 174/7206 0.0218063712092 ko04142 Lysosome 11/255 151/7206 0.0219717767552 ko04141 Protein processing in endoplasmic reticulum 1/255 184/7206 0.0229431603247 ko05160 Hepatitis C 11/255 153/7206 0.0233323962073 ko05332 Graft-versus-host disease 3/255 18/7206 0.0241102210858 ko04020 Calcium signaling pathway 3/255 265/7206 0.0262587743234 ko04080 Neuroactive ligand-receptor interaction 7/255 423/7206 0.0289749958538 ko04920 Adipocytokine signaling pathway 7/255 89/7206 0.0376624989345 ko04810 Regulation of actin cytoskeleton 16/255 264/7206 0.0387198889661 ko05416 Viral myocarditis 5/255 55/7206 0.0441296299856