ko pathway ratio_in_study ratio_in_pop p_value ko04744 Phototransduction 17/453 36/7206 7.88885998995e-12 ko04724 Glutamatergic synapse 33/453 152/7206 1.80169529515e-10 ko04911 Insulin secretion 25/453 117/7206 4.3387395619e-08 ko05032 Morphine addiction 24/453 110/7206 5.31289965259e-08 ko04727 GABAergic synapse 23/453 110/7206 2.30780768569e-07 ko04713 Circadian entrainment 26/453 136/7206 2.48071870915e-07 ko04721 Synaptic vesicle cycle 17/453 80/7206 7.01418853981e-06 ko04728 Dopaminergic synapse 28/453 185/7206 1.61981076244e-05 ko04960 Aldosterone-regulated sodium reabsorption 11/453 41/7206 3.02509747126e-05 ko05033 Nicotine addiction 13/453 56/7206 3.14724317172e-05 ko04070 Phosphatidylinositol signaling system 19/453 112/7206 6.03520652869e-05 ko04024 cAMP signaling pathway 35/453 279/7206 7.2529541269e-05 ko05031 Amphetamine addiction 16/453 91/7206 0.000148299824411 ko04725 Cholinergic synapse 23/453 160/7206 0.00017806362271 ko04710 Circadian rhythm 10/453 43/7206 0.000254834904592 ko04964 Proximal tubule bicarbonate reclamation 8/453 29/7206 0.000303783777894 ko04720 Long-term potentiation 16/453 99/7206 0.000404071947342 ko04726 Serotonergic synapse 20/453 137/7206 0.000452629666911 ko04972 Pancreatic secretion 17/453 111/7206 0.000514710418885 ko04723 Retrograde endocannabinoid signaling 23/453 175/7206 0.00069996077755 ko04970 Salivary secretion 15/453 95/7206 0.000783042505703 ko04925 Aldosterone synthesis and secretion 16/453 105/7206 0.000789692708602 ko04966 Collecting duct acid secretion 7/453 26/7206 0.000854386602008 ko03040 Spliceosome 1/453 145/7206 0.00150119789857 ko04080 Neuroactive ligand-receptor interaction 43/453 423/7206 0.00178237010249 ko04745 Phototransduction - fly 8/453 38/7206 0.00210023056828 ko04360 Axon guidance 27/453 233/7206 0.00216221416143 ko04120 Ubiquitin mediated proteolysis 1/453 138/7206 0.00218519191295 ko04971 Gastric acid secretion 14/453 98/7206 0.00472099770352 ko04514 Cell adhesion molecules (CAMs) 17/453 130/7206 0.00502345380817 ko05203 Viral carcinogenesis 7/453 277/7206 0.00524509633271 ko05110 Vibrio cholerae infection 10/453 63/7206 0.00549841375834 ko05014 Amyotrophic lateral sclerosis (ALS) 11/453 74/7206 0.00612079308343 ko04022 cGMP-PKG signaling pathway 24/453 216/7206 0.00616937510718 ko05162 Measles 1/453 120/7206 0.00683712949154 ko04014 Ras signaling pathway 29/453 279/7206 0.00760933901687 ko04261 Adrenergic signaling in cardiomyocytes 23/453 205/7206 0.00766551777866 ko04110 Cell cycle 2/453 145/7206 0.00854914523049 ko04810 Regulation of actin cytoskeleton 7/453 264/7206 0.00938422502767 ko05164 Influenza A 3/453 167/7206 0.00945855315935 ko04961 Endocrine and other factor-regulated calcium reabsorption 9/453 59/7206 0.0107052865823 ko04020 Calcium signaling pathway 27/453 265/7206 0.0133607048397 ko03013 RNA transport 3/453 166/7206 0.0137167941482 ko04973 Carbohydrate digestion and absorption 7/453 42/7206 0.0146905319199 ko00680 Methane metabolism 6/453 34/7206 0.0178403342319 ko04919 Thyroid hormone signaling pathway 16/453 143/7206 0.0221361284249 ko04626 Plant-pathogen interaction 4/453 18/7206 0.0233010127443 ko05030 Cocaine addiction 10/453 73/7206 0.0238233646664 ko00010 Glycolysis / Gluconeogenesis 10/453 74/7206 0.0247151439057 ko04510 Focal adhesion 7/453 240/7206 0.0291149836737 ko04921 Oxytocin signaling pathway 21/453 209/7206 0.0293355556311 ko04740 Olfactory transduction 10/453 80/7206 0.0328765550634 ko04976 Bile secretion 10/453 80/7206 0.0328765550634 ko02010 ABC transporters 6/453 39/7206 0.0332755560904 ko05166 HTLV-I infection 10/453 292/7206 0.0362683155493 ko04978 Mineral absorption 6/453 40/7206 0.0371522856793 ko04062 Chemokine signaling pathway 20/453 201/7206 0.0378974533001 ko05169 Epstein-Barr virus infection 6/453 206/7206 0.0407225765521 ko04657 IL-17 signaling pathway 1/453 87/7206 0.0432674427529 ko05168 Herpes simplex infection 5/453 182/7206 0.0436898480368 ko04711 Circadian rhythm - fly 3/453 13/7206 0.0440149824057 ko05120 Epithelial cell signaling in Helicobacter pylori infection 11/453 92/7206 0.0464590131981 ko00030 Pentose phosphate pathway 5/453 32/7206 0.0474340380398 ko00230 Purine metabolism 19/453 194/7206 0.0499300113237