ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	194/1200	423/7206	4.47651751538e-48
ko04724	Glutamatergic synapse	88/1200	152/7206	2.32401872065e-31
ko05033	Nicotine addiction	47/1200	56/7206	1.93766307235e-28
ko05032	Morphine addiction	67/1200	110/7206	6.81321391551e-26
ko04713	Circadian entrainment	75/1200	136/7206	5.22975470734e-25
ko04727	GABAergic synapse	64/1200	110/7206	3.1688509398e-23
ko04728	Dopaminergic synapse	85/1200	185/7206	3.70651058559e-21
ko04725	Cholinergic synapse	74/1200	160/7206	9.35228080479e-19
ko04721	Synaptic vesicle cycle	48/1200	80/7206	1.7378751239e-18
ko04020	Calcium signaling pathway	102/1200	265/7206	3.78885744754e-18
ko04723	Retrograde endocannabinoid signaling	76/1200	175/7206	2.79317442183e-17
ko04742	Taste transduction	39/1200	61/7206	1.30050506143e-16
ko04911	Insulin secretion	57/1200	117/7206	5.49999250635e-16
ko04024	cAMP signaling pathway	101/1200	279/7206	8.05165493341e-16
ko04744	Phototransduction	28/1200	36/7206	9.3676493246e-16
ko04921	Oxytocin signaling pathway	81/1200	209/7206	7.78209845023e-15
ko04726	Serotonergic synapse	61/1200	137/7206	1.04072388091e-14
ko04740	Olfactory transduction	41/1200	80/7206	8.69131870805e-13
ko05031	Amphetamine addiction	41/1200	91/7206	1.66195674572e-10
ko04261	Adrenergic signaling in cardiomyocytes	71/1200	205/7206	2.08876035957e-10
ko04720	Long-term potentiation	43/1200	99/7206	2.53360063125e-10
ko04970	Salivary secretion	41/1200	95/7206	8.41292495508e-10
ko03040	Spliceosome	2/1200	145/7206	2.58516171743e-09
ko05203	Viral carcinogenesis	16/1200	277/7206	5.8181574702e-08
ko04925	Aldosterone synthesis and secretion	40/1200	105/7206	9.87050752812e-08
ko04022	cGMP-PKG signaling pathway	67/1200	216/7206	1.24697677358e-07
ko04971	Gastric acid secretion	38/1200	98/7206	1.30282575406e-07
ko05322	Systemic lupus erythematosus	5/1200	151/7206	3.80338159824e-07
ko04060	Cytokine-cytokine receptor interaction	9/1200	191/7206	5.59002478645e-07
ko04360	Axon guidance	69/1200	233/7206	6.06460138384e-07
ko03013	RNA transport	7/1200	166/7206	1.30617058352e-06
ko05168	Herpes simplex infection	9/1200	182/7206	2.40375066667e-06
ko04621	NOD-like receptor signaling pathway	7/1200	157/7206	3.7258883674e-06
ko05030	Cocaine addiction	28/1200	73/7206	8.37057266619e-06
ko04745	Phototransduction - fly	18/1200	38/7206	1.00497132185e-05
ko04730	Long-term depression	29/1200	78/7206	1.02122933588e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1200	74/7206	1.0539423809e-05
ko04010	MAPK signaling pathway	84/1200	321/7206	1.06344301861e-05
ko04120	Ubiquitin mediated proteolysis	6/1200	138/7206	1.38734117107e-05
ko04514	Cell adhesion molecules (CAMs)	41/1200	130/7206	2.32094985281e-05
ko04972	Pancreatic secretion	36/1200	111/7206	4.69461536726e-05
ko04141	Protein processing in endoplasmic reticulum	12/1200	184/7206	5.21570362433e-05
ko05164	Influenza A	10/1200	167/7206	5.24578241529e-05
ko04110	Cell cycle	8/1200	145/7206	6.79753040618e-05
ko04260	Cardiac muscle contraction	32/1200	98/7206	9.30456899474e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1200	79/7206	0.000111807266775
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1200	79/7206	0.000180469959983
ko05140	Leishmaniasis	2/1200	75/7206	0.000248742851749
ko04540	Gap junction	38/1200	128/7206	0.000265929949389
ko04064	NF-kappa B signaling pathway	4/1200	96/7206	0.000271268968859
ko05169	Epstein-Barr virus infection	16/1200	206/7206	0.000274826513565
ko04924	Renin secretion	28/1200	86/7206	0.000351071262606
ko04976	Bile secretion	26/1200	80/7206	0.000418264055942
ko05205	Proteoglycans in cancer	25/1200	271/7206	0.000456949474851
ko05166	HTLV-I infection	28/1200	292/7206	0.000542579031026
ko05161	Hepatitis B	13/1200	173/7206	0.000585766244231
ko04610	Complement and coagulation cascades	3/1200	79/7206	0.000695597951352
ko04070	Phosphatidylinositol signaling system	33/1200	112/7206	0.000740573442573
ko04750	Inflammatory mediator regulation of TRP channels	35/1200	122/7206	0.000808393589367
ko04146	Peroxisome	4/1200	89/7206	0.000818739329266
ko00520	Amino sugar and nucleotide sugar metabolism	1/1200	55/7206	0.000839346674755
ko00480	Glutathione metabolism	1/1200	55/7206	0.000839346674755
ko04072	Phospholipase D signaling pathway	51/1200	197/7206	0.000894072955097
ko04014	Ras signaling pathway	67/1200	279/7206	0.00132231179382
ko04371	Apelin signaling pathway	46/1200	177/7206	0.00142620419195
ko04966	Collecting duct acid secretion	11/1200	26/7206	0.00176943960645
ko05162	Measles	8/1200	120/7206	0.00181437691621
ko00240	Pyrimidine metabolism	7/1200	110/7206	0.00183622650948
ko04930	Type II diabetes mellitus	18/1200	54/7206	0.00262653513494
ko05110	Vibrio cholerae infection	20/1200	63/7206	0.00318382536559
ko04657	IL-17 signaling pathway	5/1200	87/7206	0.00350531929853
ko05144	Malaria	1/1200	45/7206	0.00434553781576
ko00071	Fatty acid degradation	1/1200	45/7206	0.00434553781576
ko03420	Nucleotide excision repair	1/1200	46/7206	0.00443521374016
ko04350	TGF-beta signaling pathway	7/1200	103/7206	0.00478175292273
ko04964	Proximal tubule bicarbonate reclamation	11/1200	29/7206	0.00489778802972
ko04612	Antigen processing and presentation	4/1200	77/7206	0.00493845110175
ko04626	Plant-pathogen interaction	8/1200	18/7206	0.00525252822027
ko05321	Inflammatory bowel disease (IBD)	2/1200	56/7206	0.00583561465377
ko04915	Estrogen signaling pathway	34/1200	131/7206	0.00616750132754
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1200	182/7206	0.00623722659969
ko05414	Dilated cardiomyopathy	30/1200	112/7206	0.00671980677794
ko00310	Lysine degradation	4/1200	73/7206	0.00674415301517
ko03022	Basal transcription factors	1/1200	44/7206	0.00682135659888
ko05131	Shigellosis	5/1200	82/7206	0.00683896853586
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1200	59/7206	0.00758841977397
ko04217	Necroptosis	17/1200	178/7206	0.00794725193678
ko04922	Glucagon signaling pathway	33/1200	128/7206	0.00802624799019
ko04630	Jak-STAT signaling pathway	11/1200	132/7206	0.00894647211844
ko05016	Huntington's disease	22/1200	215/7206	0.00903889333342
ko04330	Notch signaling pathway	3/1200	62/7206	0.00921943178329
ko04622	RIG-I-like receptor signaling pathway	3/1200	62/7206	0.00921943178329
ko04214	Apoptosis - fly	4/1200	72/7206	0.00986318399755
ko04142	Lysosome	14/1200	151/7206	0.0110473627361
ko04710	Circadian rhythm	14/1200	43/7206	0.0114958811241
ko05133	Pertussis	6/1200	87/7206	0.0128937149971
ko01524	Platinum drug resistance	5/1200	76/7206	0.0131620104825
ko05215	Prostate cancer	9/1200	111/7206	0.0139807234099
ko04140	Autophagy - animal	16/1200	164/7206	0.014499084371
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1200	100/7206	0.0148785454787
ko05145	Toxoplasmosis	11/1200	126/7206	0.0152011049186
ko03018	RNA degradation	6/1200	84/7206	0.0174169177089
ko05219	Bladder cancer	2/1200	48/7206	0.0177487583631
ko04115	p53 signaling pathway	5/1200	74/7206	0.0180987237155
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1200	14/7206	0.0188975388199
ko05418	Fluid shear stress and atherosclerosis	18/1200	173/7206	0.0230343822553
ko04210	Apoptosis	19/1200	180/7206	0.0254695244884
ko04668	TNF signaling pathway	11/1200	120/7206	0.0255598709721
ko00280	Valine, leucine and isoleucine degradation	3/1200	54/7206	0.0263251665707
ko04640	Hematopoietic cell lineage	4/1200	64/7206	0.0265930670389
ko04658	Th1 and Th2 cell differentiation	8/1200	96/7206	0.026600351513
ko05206	MicroRNAs in cancer	19/1200	177/7206	0.0316735572008
ko04978	Mineral absorption	12/1200	40/7206	0.0317034046479
ko05200	Pathways in cancer	65/1200	492/7206	0.0330628967897
ko00860	Porphyrin and chlorophyll metabolism	1/1200	34/7206	0.0340335572522
ko04113	Meiosis - yeast	5/1200	70/7206	0.0344205781433
ko04960	Aldosterone-regulated sodium reabsorption	12/1200	41/7206	0.0360953004335
ko00330	Arginine and proline metabolism	4/1200	61/7206	0.0364098172225
ko04974	Protein digestion and absorption	24/1200	96/7206	0.0372283505213
ko04620	Toll-like receptor signaling pathway	9/1200	100/7206	0.0415413823483
ko04923	Regulation of lipolysis in adipocytes	20/1200	77/7206	0.0436587521711
ko04550	Signaling pathways regulating pluripotency of stem cells	18/1200	165/7206	0.0445458612236
ko00562	Inositol phosphate metabolism	22/1200	89/7206	0.0450502278848
ko04933	AGE-RAGE signaling pathway in diabetic complications	14/1200	135/7206	0.0473984112246
ko05217	Basal cell carcinoma	5/1200	68/7206	0.0474720421337