ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	205/1251	423/7206	1.0922554987e-52
ko05033	Nicotine addiction	47/1251	56/7206	1.32044224784e-27
ko04724	Glutamatergic synapse	85/1251	152/7206	1.81637377065e-27
ko04713	Circadian entrainment	77/1251	136/7206	1.92639931026e-25
ko05032	Morphine addiction	65/1251	110/7206	4.69073725085e-23
ko04727	GABAergic synapse	64/1251	110/7206	3.3204102847e-22
ko04728	Dopaminergic synapse	86/1251	185/7206	1.43078251561e-20
ko04020	Calcium signaling pathway	109/1251	265/7206	1.56812228561e-20
ko04725	Cholinergic synapse	72/1251	160/7206	1.93010749217e-16
ko04723	Retrograde endocannabinoid signaling	76/1251	175/7206	3.17412369819e-16
ko04721	Synaptic vesicle cycle	46/1251	80/7206	5.04894152776e-16
ko04742	Taste transduction	39/1251	61/7206	5.64060953355e-16
ko04024	cAMP signaling pathway	104/1251	279/7206	6.29571080567e-16
ko04911	Insulin secretion	58/1251	117/7206	7.84695949516e-16
ko04744	Phototransduction	28/1251	36/7206	2.85136141379e-15
ko04921	Oxytocin signaling pathway	83/1251	209/7206	1.01883830042e-14
ko04726	Serotonergic synapse	60/1251	137/7206	2.93959973963e-13
ko04261	Adrenergic signaling in cardiomyocytes	77/1251	205/7206	3.19086976458e-12
ko03040	Spliceosome	2/1251	145/7206	5.93379498701e-10
ko04970	Salivary secretion	42/1251	95/7206	7.93747051891e-10
ko04740	Olfactory transduction	37/1251	80/7206	1.74724651395e-09
ko05031	Amphetamine addiction	40/1251	91/7206	2.48009179015e-09
ko05203	Viral carcinogenesis	16/1251	277/7206	9.16409872884e-09
ko04720	Long-term potentiation	41/1251	99/7206	1.86834310755e-08
ko04022	cGMP-PKG signaling pathway	71/1251	216/7206	2.38260273381e-08
ko04925	Aldosterone synthesis and secretion	41/1251	105/7206	1.36481005627e-07
ko05322	Systemic lupus erythematosus	5/1251	151/7206	1.66145592758e-07
ko04360	Axon guidance	72/1251	233/7206	2.41871238187e-07
ko03013	RNA transport	7/1251	166/7206	3.80205338705e-07
ko04971	Gastric acid secretion	38/1251	98/7206	4.95751316677e-07
ko04621	NOD-like receptor signaling pathway	7/1251	157/7206	1.73140800379e-06
ko05168	Herpes simplex infection	10/1251	182/7206	2.29447190442e-06
ko04060	Cytokine-cytokine receptor interaction	11/1251	191/7206	2.4442745075e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	31/1251	79/7206	3.36779397831e-06
ko04514	Cell adhesion molecules (CAMs)	44/1251	130/7206	5.57536314187e-06
ko05030	Cocaine addiction	29/1251	73/7206	5.65578243402e-06
ko05164	Influenza A	9/1251	167/7206	6.23619641523e-06
ko04010	MAPK signaling pathway	87/1251	321/7206	7.66744418317e-06
ko04260	Cardiac muscle contraction	35/1251	98/7206	1.06226171309e-05
ko04730	Long-term depression	29/1251	78/7206	2.74815966656e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1251	74/7206	3.22281450059e-05
ko04976	Bile secretion	29/1251	80/7206	4.18833693107e-05
ko04070	Phosphatidylinositol signaling system	37/1251	112/7206	4.44263589931e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1251	79/7206	7.01634116578e-05
ko04745	Phototransduction - fly	17/1251	38/7206	7.74465869217e-05
ko05169	Epstein-Barr virus infection	16/1251	206/7206	7.89624716087e-05
ko04120	Ubiquitin mediated proteolysis	8/1251	138/7206	9.09600703063e-05
ko04972	Pancreatic secretion	36/1251	111/7206	0.000112387516524
ko04110	Cell cycle	9/1251	145/7206	0.000134290148366
ko05205	Proteoglycans in cancer	25/1251	271/7206	0.000155325741141
ko04141	Protein processing in endoplasmic reticulum	14/1251	184/7206	0.000159319998741
ko05140	Leishmaniasis	2/1251	75/7206	0.000160847555067
ko04064	NF-kappa B signaling pathway	4/1251	96/7206	0.00018513700077
ko05161	Hepatitis B	13/1251	173/7206	0.000226031678524
ko05414	Dilated cardiomyopathy	35/1251	112/7206	0.000345001907456
ko04610	Complement and coagulation cascades	3/1251	79/7206	0.000459204475625
ko04930	Type II diabetes mellitus	20/1251	54/7206	0.000461668592266
ko04924	Renin secretion	28/1251	86/7206	0.000500981342675
ko00520	Amino sugar and nucleotide sugar metabolism	1/1251	55/7206	0.000527482945891
ko04540	Gap junction	38/1251	128/7206	0.000546136917097
ko05162	Measles	8/1251	120/7206	0.000916818497895
ko04072	Phospholipase D signaling pathway	52/1251	197/7206	0.00114470415939
ko04750	Inflammatory mediator regulation of TRP channels	35/1251	122/7206	0.00161061526839
ko04146	Peroxisome	5/1251	89/7206	0.00170987206428
ko04371	Apelin signaling pathway	47/1251	177/7206	0.001769345592
ko04964	Proximal tubule bicarbonate reclamation	12/1251	29/7206	0.00202005732783
ko04612	Antigen processing and presentation	4/1251	77/7206	0.00227367136254
ko04657	IL-17 signaling pathway	5/1251	87/7206	0.00243630614919
ko04014	Ras signaling pathway	68/1251	279/7206	0.00273667060682
ko03420	Nucleotide excision repair	1/1251	46/7206	0.0027870305755
ko00240	Pyrimidine metabolism	8/1251	110/7206	0.00325418889041
ko05410	Hypertrophic cardiomyopathy (HCM)	29/1251	100/7206	0.0033019697704
ko05215	Prostate cancer	8/1251	111/7206	0.00332240312816
ko03018	RNA degradation	5/1251	84/7206	0.00339059270335
ko05321	Inflammatory bowel disease (IBD)	2/1251	56/7206	0.0038065805766
ko03022	Basal transcription factors	1/1251	44/7206	0.00425139519021
ko05144	Malaria	1/1251	45/7206	0.00449679139244
ko00071	Fatty acid degradation	1/1251	45/7206	0.00449679139244
ko00310	Lysine degradation	4/1251	73/7206	0.00463789660219
ko04217	Necroptosis	17/1251	178/7206	0.00475442621681
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1251	59/7206	0.00502754696206
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1251	182/7206	0.00538623495693
ko00590	Arachidonic acid metabolism	2/1251	52/7206	0.00541438010486
ko04622	RIG-I-like receptor signaling pathway	3/1251	62/7206	0.00623700441268
ko04658	Th1 and Th2 cell differentiation	7/1251	96/7206	0.00630137677881
ko05133	Pertussis	6/1251	87/7206	0.0065207268077
ko05166	HTLV-I infection	34/1251	292/7206	0.00723236623881
ko04966	Collecting duct acid secretion	10/1251	26/7206	0.00868478630235
ko03410	Base excision repair	1/1251	38/7206	0.00954066206622
ko04620	Toll-like receptor signaling pathway	8/1251	100/7206	0.0109529278663
ko05110	Vibrio cholerae infection	19/1251	63/7206	0.0113424859901
ko05219	Bladder cancer	2/1251	48/7206	0.0116912922223
ko05131	Shigellosis	6/1251	82/7206	0.0123010791157
ko04210	Apoptosis	19/1251	180/7206	0.0125826138429
ko04115	p53 signaling pathway	5/1251	74/7206	0.0128159791832
ko04270	Vascular smooth muscle contraction	39/1251	154/7206	0.0128479834161
ko04710	Circadian rhythm	14/1251	43/7206	0.0138978281806
ko04923	Regulation of lipolysis in adipocytes	22/1251	77/7206	0.0144612293305
ko04711	Circadian rhythm - fly	6/1251	13/7206	0.0153379150687
ko05145	Toxoplasmosis	12/1251	126/7206	0.0172511441497
ko04214	Apoptosis - fly	5/1251	72/7206	0.0178473299589
ko00280	Valine, leucine and isoleucine degradation	3/1251	54/7206	0.018043739549
ko00480	Glutathione metabolism	3/1251	55/7206	0.0184551247892
ko04630	Jak-STAT signaling pathway	13/1251	132/7206	0.0199572989089
ko04915	Estrogen signaling pathway	33/1251	131/7206	0.0199734607856
ko00860	Porphyrin and chlorophyll metabolism	1/1251	34/7206	0.021495696794
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1251	14/7206	0.0229707678073
ko04113	Meiosis - yeast	5/1251	70/7206	0.0248465628276
ko04922	Glucagon signaling pathway	32/1251	128/7206	0.0251784754057
ko04626	Plant-pathogen interaction	7/1251	18/7206	0.0253023805113
ko00330	Arginine and proline metabolism	4/1251	61/7206	0.0256810714223
ko04140	Autophagy - animal	18/1251	164/7206	0.0282180810235
ko04142	Lysosome	16/1251	151/7206	0.0291355903298
ko01524	Platinum drug resistance	6/1251	76/7206	0.0314995200119
ko01200	Carbon metabolism	13/1251	128/7206	0.0331416323515
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1251	40/7206	0.0355776553186
ko00380	Tryptophan metabolism	3/1251	50/7206	0.0369236665762
ko05200	Pathways in cancer	69/1251	492/7206	0.0419907793156
ko05016	Huntington's disease	26/1251	215/7206	0.0437200088533
ko04640	Hematopoietic cell lineage	5/1251	64/7206	0.0453842437678
ko05320	Autoimmune thyroid disease	1/1251	29/7206	0.0478856482573