ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 47/422 145/7206 1.78974228423e-23 ko03013 RNA transport 48/422 166/7206 1.53414646791e-21 ko03008 Ribosome biogenesis in eukaryotes 28/422 79/7206 1.5387650856e-15 ko03030 DNA replication 20/422 38/7206 1.83341366743e-15 ko04111 Cell cycle - yeast 23/422 90/7206 1.02279901329e-09 ko04080 Neuroactive ligand-receptor interaction 2/422 423/7206 2.92684147337e-09 ko04110 Cell cycle 29/422 145/7206 3.43948391194e-09 ko03430 Mismatch repair 10/422 22/7206 1.46174001092e-07 ko03015 mRNA surveillance pathway 20/422 93/7206 2.86478031457e-07 ko04113 Meiosis - yeast 16/422 70/7206 1.9093321785e-06 ko03440 Homologous recombination 12/422 41/7206 2.32258692672e-06 ko03018 RNA degradation 17/422 84/7206 5.44525799209e-06 ko03420 Nucleotide excision repair 12/422 46/7206 8.7506624188e-06 ko04020 Calcium signaling pathway 2/422 265/7206 2.45104615029e-05 ko04022 cGMP-PKG signaling pathway 1/422 216/7206 4.71716132107e-05 ko04921 Oxytocin signaling pathway 1/422 209/7206 6.95959666404e-05 ko05010 Alzheimer's disease 1/422 202/7206 0.000102604888082 ko04261 Adrenergic signaling in cardiomyocytes 1/422 205/7206 0.000106178814168 ko00240 Pyrimidine metabolism 17/422 110/7206 0.000200708941819 ko04728 Dopaminergic synapse 1/422 185/7206 0.000340573219762 ko04723 Retrograde endocannabinoid signaling 1/422 175/7206 0.00048168143806 ko04371 Apelin signaling pathway 1/422 177/7206 0.000490309109699 ko04068 FoxO signaling pathway 1/422 167/7206 0.000705550053946 ko04910 Insulin signaling pathway 1/422 172/7206 0.000741613680046 ko03050 Proteasome 10/422 54/7206 0.000996637943463 ko04152 AMPK signaling pathway 1/422 161/7206 0.00103453968586 ko03410 Base excision repair 8/422 38/7206 0.00133495728983 ko05166 HTLV-I infection 30/422 292/7206 0.00214501812784 ko05034 Alcoholism 4/422 238/7206 0.00279755333457 ko04217 Necroptosis 2/422 178/7206 0.00304131204102 ko00970 Aminoacyl-tRNA biosynthesis 8/422 44/7206 0.00355566875774 ko04024 cAMP signaling pathway 6/422 279/7206 0.00399358082897 ko05169 Epstein-Barr virus infection 22/422 206/7206 0.00597205292124 ko04611 Platelet activation 2/422 163/7206 0.00610756233297 ko04141 Protein processing in endoplasmic reticulum 20/422 184/7206 0.00636851728011 ko00190 Oxidative phosphorylation 1/422 127/7206 0.00685329600443 ko04540 Gap junction 1/422 128/7206 0.00688428314127 ko05016 Huntington's disease 4/422 215/7206 0.00731456301792 ko00230 Purine metabolism 21/422 194/7206 0.00736147957898 ko04270 Vascular smooth muscle contraction 2/422 154/7206 0.00858028427065 ko05012 Parkinson's disease 2/422 155/7206 0.00861400320961 ko03460 Fanconi anemia pathway 8/422 51/7206 0.00893660936062 ko03450 Non-homologous end-joining 4/422 15/7206 0.00943950841844 ko05217 Basal cell carcinoma 9/422 68/7206 0.0169329761788 ko04144 Endocytosis 10/422 342/7206 0.0174459505724 ko04925 Aldosterone synthesis and secretion 1/422 105/7206 0.0208972180475 ko04630 Jak-STAT signaling pathway 2/422 132/7206 0.0241943456886 ko03020 RNA polymerase 5/422 29/7206 0.0249050493222 ko04931 Insulin resistance 2/422 137/7206 0.0249845369709 ko04151 PI3K-Akt signaling pathway 13/422 390/7206 0.026282024458 ko00670 One carbon pool by folate 4/422 20/7206 0.0265881038225 ko04514 Cell adhesion molecules (CAMs) 2/422 130/7206 0.0350705339522 ko04932 Non-alcoholic fatty liver disease (NAFLD) 4/422 182/7206 0.0354168422471 ko00030 Pentose phosphate pathway 5/422 32/7206 0.0366203337832 ko04120 Ubiquitin mediated proteolysis 14/422 138/7206 0.0414130219802 ko04072 Phospholipase D signaling pathway 5/422 197/7206 0.0441358724034 ko04810 Regulation of actin cytoskeleton 8/422 264/7206 0.0446524532078 ko04974 Protein digestion and absorption 1/422 96/7206 0.0447069165556 ko04062 Chemokine signaling pathway 5/422 201/7206 0.045310863731 ko04668 TNF signaling pathway 2/422 120/7206 0.0478102893366 ko04750 Inflammatory mediator regulation of TRP channels 2/422 122/7206 0.0485298920692 ko04066 HIF-1 signaling pathway 2/422 123/7206 0.0490627465006 ko04510 Focal adhesion 7/422 240/7206 0.0492495495042