ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 178/1018 423/7206 2.662116617e-48 ko04724 Glutamatergic synapse 83/1018 152/7206 1.8854997519e-32 ko05033 Nicotine addiction 47/1018 56/7206 9.37043771139e-32 ko04713 Circadian entrainment 71/1018 136/7206 2.89439335334e-26 ko05032 Morphine addiction 61/1018 110/7206 1.4589806825e-24 ko04727 GABAergic synapse 60/1018 110/7206 1.14673631522e-23 ko04721 Synaptic vesicle cycle 48/1018 80/7206 1.38314445662e-21 ko04728 Dopaminergic synapse 78/1018 185/7206 3.31102852036e-21 ko04725 Cholinergic synapse 68/1018 160/7206 7.6920521204e-19 ko04723 Retrograde endocannabinoid signaling 71/1018 175/7206 2.84839533946e-18 ko04024 cAMP signaling pathway 93/1018 279/7206 8.70112796338e-17 ko04742 Taste transduction 36/1018 61/7206 3.62472082553e-16 ko04020 Calcium signaling pathway 85/1018 265/7206 2.50374761149e-14 ko04911 Insulin secretion 50/1018 117/7206 2.81245460969e-14 ko04921 Oxytocin signaling pathway 72/1018 209/7206 5.40994467208e-14 ko04726 Serotonergic synapse 54/1018 137/7206 1.49347368293e-13 ko05031 Amphetamine addiction 40/1018 91/7206 3.74329467179e-12 ko04261 Adrenergic signaling in cardiomyocytes 66/1018 205/7206 2.87553886925e-11 ko04720 Long-term potentiation 39/1018 99/7206 3.88891790081e-10 ko04970 Salivary secretion 37/1018 95/7206 1.60648016597e-09 ko04744 Phototransduction 20/1018 36/7206 6.46843273895e-09 ko03040 Spliceosome 1/1018 145/7206 9.03829330075e-09 ko05203 Viral carcinogenesis 11/1018 277/7206 2.88934384316e-08 ko04925 Aldosterone synthesis and secretion 36/1018 105/7206 1.29703371504e-07 ko04740 Olfactory transduction 30/1018 80/7206 1.5413059916e-07 ko05030 Cocaine addiction 28/1018 73/7206 2.3033473637e-07 ko04022 cGMP-PKG signaling pathway 58/1018 216/7206 7.37463323501e-07 ko04745 Phototransduction - fly 18/1018 38/7206 8.85393347638e-07 ko04971 Gastric acid secretion 33/1018 98/7206 9.89353612366e-07 ko05168 Herpes simplex infection 6/1018 182/7206 1.40519677682e-06 ko04360 Axon guidance 60/1018 233/7206 1.96539543078e-06 ko04966 Collecting duct acid secretion 14/1018 26/7206 2.12363253714e-06 ko04060 Cytokine-cytokine receptor interaction 7/1018 191/7206 2.43087784303e-06 ko05322 Systemic lupus erythematosus 4/1018 151/7206 2.62903223709e-06 ko04120 Ubiquitin mediated proteolysis 3/1018 138/7206 2.82096098538e-06 ko04730 Long-term depression 27/1018 78/7206 3.915691212e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 26/1018 74/7206 4.30516284603e-06 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 27/1018 79/7206 5.16217585849e-06 ko04010 MAPK signaling pathway 75/1018 321/7206 5.38931116295e-06 ko04621 NOD-like receptor signaling pathway 5/1018 157/7206 7.23143194472e-06 ko05164 Influenza A 6/1018 167/7206 8.62631368045e-06 ko04260 Cardiac muscle contraction 30/1018 98/7206 2.43762786793e-05 ko03013 RNA transport 7/1018 166/7206 3.98659432957e-05 ko04514 Cell adhesion molecules (CAMs) 36/1018 130/7206 5.72099743662e-05 ko04141 Protein processing in endoplasmic reticulum 9/1018 184/7206 6.30076855803e-05 ko05110 Vibrio cholerae infection 21/1018 63/7206 8.65458264389e-05 ko04924 Renin secretion 26/1018 86/7206 0.000115035733181 ko04972 Pancreatic secretion 31/1018 111/7206 0.000148667664728 ko05205 Proteoglycans in cancer 19/1018 271/7206 0.0003398783397 ko04110 Cell cycle 7/1018 145/7206 0.000420894437175 ko05169 Epstein-Barr virus infection 13/1018 206/7206 0.000510814302342 ko05162 Measles 5/1018 120/7206 0.000524266192662 ko04064 NF-kappa B signaling pathway 3/1018 96/7206 0.000568484074846 ko05161 Hepatitis B 10/1018 173/7206 0.00080681354876 ko04072 Phospholipase D signaling pathway 45/1018 197/7206 0.000821632903087 ko05414 Dilated cardiomyopathy 29/1018 112/7206 0.000873041159787 ko04070 Phosphatidylinositol signaling system 29/1018 112/7206 0.000873041159787 ko03008 Ribosome biogenesis in eukaryotes 2/1018 79/7206 0.000952207086739 ko04961 Endocrine and other factor-regulated calcium reabsorption 18/1018 59/7206 0.00103242807482 ko05166 HTLV-I infection 23/1018 292/7206 0.001069824398 ko04612 Antigen processing and presentation 2/1018 77/7206 0.00142131986973 ko05215 Prostate cancer 5/1018 111/7206 0.00146186152236 ko04540 Gap junction 31/1018 128/7206 0.00193595852447 ko05140 Leishmaniasis 2/1018 75/7206 0.00215823344007 ko04214 Apoptosis - fly 2/1018 72/7206 0.00313607941576 ko04976 Bile secretion 21/1018 80/7206 0.00343125148235 ko05410 Hypertrophic cardiomyopathy (HCM) 25/1018 100/7206 0.00343164407248 ko04014 Ras signaling pathway 57/1018 279/7206 0.00363886050711 ko04750 Inflammatory mediator regulation of TRP channels 29/1018 122/7206 0.00366983881982 ko04350 TGF-beta signaling pathway 5/1018 103/7206 0.00399029249521 ko04371 Apelin signaling pathway 39/1018 177/7206 0.00419193390916 ko04964 Proximal tubule bicarbonate reclamation 10/1018 29/7206 0.00473358760644 ko04210 Apoptosis 13/1018 180/7206 0.00476019045221 ko04630 Jak-STAT signaling pathway 8/1018 132/7206 0.00516279367652 ko00480 Glutathione metabolism 1/1018 55/7206 0.00522969637124 ko04146 Peroxisome 4/1018 89/7206 0.0053808722995 ko04217 Necroptosis 13/1018 178/7206 0.0062023079265 ko04640 Hematopoietic cell lineage 2/1018 64/7206 0.0062937192675 ko01524 Platinum drug resistance 3/1018 76/7206 0.00721649290601 ko05220 Chronic myeloid leukemia 4/1018 85/7206 0.00754385627294 ko04626 Plant-pathogen interaction 7/1018 18/7206 0.00844597048551 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/1018 14/7206 0.00853391920543 ko04550 Signaling pathways regulating pluripotency of stem cells 12/1018 165/7206 0.00889723765009 ko04930 Type II diabetes mellitus 15/1018 54/7206 0.00896534084575 ko04330 Notch signaling pathway 2/1018 62/7206 0.00922434094587 ko03022 Basal transcription factors 1/1018 44/7206 0.0161396799745 ko05144 Malaria 1/1018 45/7206 0.0163060769025 ko00071 Fatty acid degradation 1/1018 45/7206 0.0163060769025 ko04668 TNF signaling pathway 8/1018 120/7206 0.0165626304612 ko00620 Pyruvate metabolism 1/1018 46/7206 0.0168679936056 ko03420 Nucleotide excision repair 1/1018 46/7206 0.0168679936056 ko04932 Non-alcoholic fatty liver disease (NAFLD) 15/1018 182/7206 0.0177034716979 ko00240 Pyrimidine metabolism 7/1018 110/7206 0.0179866180313 ko05321 Inflammatory bowel disease (IBD) 2/1018 56/7206 0.0191820828326 ko04657 IL-17 signaling pathway 5/1018 87/7206 0.0197483853659 ko05145 Toxoplasmosis 9/1018 126/7206 0.0199099332119 ko04915 Estrogen signaling pathway 28/1018 131/7206 0.0219653238114 ko04140 Autophagy - animal 13/1018 164/7206 0.0225176878278 ko05120 Epithelial cell signaling in Helicobacter pylori infection 21/1018 92/7206 0.0227168590965 ko04510 Focal adhesion 22/1018 240/7206 0.0234520721921 ko04658 Th1 and Th2 cell differentiation 6/1018 96/7206 0.0256526744698 ko05200 Pathways in cancer 53/1018 492/7206 0.0267691299923 ko03018 RNA degradation 5/1018 84/7206 0.0268957417975 ko00310 Lysine degradation 4/1018 73/7206 0.0280295669596 ko04115 p53 signaling pathway 4/1018 74/7206 0.0280938752615 ko04218 Cellular senescence 15/1018 177/7206 0.028359556053 ko05131 Shigellosis 5/1018 82/7206 0.0367364353769 ko05212 Pancreatic cancer 5/1018 83/7206 0.0373874118377 ko00380 Tryptophan metabolism 2/1018 50/7206 0.0394042530958 ko00330 Arginine and proline metabolism 3/1018 61/7206 0.0401381511671 ko04973 Carbohydrate digestion and absorption 11/1018 42/7206 0.0409875871523 ko04622 RIG-I-like receptor signaling pathway 3/1018 62/7206 0.0411447635781 ko04620 Toll-like receptor signaling pathway 7/1018 100/7206 0.0416990779958 ko05222 Small cell lung cancer 6/1018 89/7206 0.045460750391 ko04912 GnRH signaling pathway 25/1018 122/7206 0.0486512926458 ko04923 Regulation of lipolysis in adipocytes 17/1018 77/7206 0.0488981338822 ko05206 MicroRNAs in cancer 16/1018 177/7206 0.049061494278