ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 53/373 145/7206 4.13379263551e-32 ko03022 Basal transcription factors 23/373 44/7206 1.01002415085e-18 ko03013 RNA transport 39/373 166/7206 3.81188081033e-16 ko04110 Cell cycle 33/373 145/7206 2.13788685974e-13 ko03460 Fanconi anemia pathway 19/373 51/7206 2.47431913003e-12 ko03018 RNA degradation 23/373 84/7206 1.86563457149e-11 ko03440 Homologous recombination 16/373 41/7206 6.07597422748e-11 ko04113 Meiosis - yeast 17/373 70/7206 6.03471805813e-08 ko03020 RNA polymerase 11/373 29/7206 9.19338888573e-08 ko04111 Cell cycle - yeast 19/373 90/7206 1.13214028282e-07 ko04144 Endocytosis 1/373 342/7206 2.73171949795e-07 ko03420 Nucleotide excision repair 12/373 46/7206 2.43449903343e-06 ko04151 PI3K-Akt signaling pathway 4/373 390/7206 1.5912550792e-05 ko04914 Progesterone-mediated oocyte maturation 17/373 104/7206 2.07754572561e-05 ko03008 Ribosome biogenesis in eukaryotes 14/373 79/7206 4.44423321775e-05 ko05200 Pathways in cancer 8/373 492/7206 4.96071145348e-05 ko03450 Non-homologous end-joining 6/373 15/7206 6.20638658895e-05 ko04024 cAMP signaling pathway 2/373 279/7206 7.9305290058e-05 ko04114 Oocyte meiosis 19/373 139/7206 8.95271441967e-05 ko03410 Base excision repair 9/373 38/7206 0.000103472169942 ko04360 Axon guidance 1/373 233/7206 0.000111306688919 ko04810 Regulation of actin cytoskeleton 2/373 264/7206 0.000168523761706 ko04022 cGMP-PKG signaling pathway 1/373 216/7206 0.00023432266011 ko04261 Adrenergic signaling in cardiomyocytes 1/373 205/7206 0.000335549478992 ko04014 Ras signaling pathway 3/373 279/7206 0.000451664390081 ko04072 Phospholipase D signaling pathway 1/373 197/7206 0.000492595289965 ko00240 Pyrimidine metabolism 15/373 110/7206 0.000501916507402 ko04510 Focal adhesion 2/373 240/7206 0.000505697063665 ko04120 Ubiquitin mediated proteolysis 17/373 138/7206 0.000722024491564 ko04728 Dopaminergic synapse 1/373 185/7206 0.00108089188698 ko04723 Retrograde endocannabinoid signaling 1/373 175/7206 0.00155165700667 ko04015 Rap1 signaling pathway 4/373 278/7206 0.00205230974147 ko05205 Proteoglycans in cancer 4/373 271/7206 0.00288762161 ko03030 DNA replication 7/373 38/7206 0.00294851714755 ko04062 Chemokine signaling pathway 2/373 201/7206 0.00308575691783 ko05169 Epstein-Barr virus infection 21/373 206/7206 0.00335437199562 ko04623 Cytosolic DNA-sensing pathway 7/373 41/7206 0.00459710791133 ko05012 Parkinson's disease 1/373 155/7206 0.00494451825441 ko03060 Protein export 5/373 23/7206 0.0056149771493 ko05152 Tuberculosis 2/373 187/7206 0.00639290866381 ko05224 Breast cancer 2/373 174/7206 0.00871785339458 ko05206 MicroRNAs in cancer 2/373 177/7206 0.0088547801586 ko04010 MAPK signaling pathway 7/373 321/7206 0.00951636567661 ko04931 Insulin resistance 1/373 137/7206 0.0101792185101 ko04910 Insulin signaling pathway 2/373 172/7206 0.0129657561178 ko01200 Carbon metabolism 1/373 128/7206 0.0146781376579 ko05142 Chagas disease (American trypanosomiasis) 1/373 130/7206 0.0148160304406 ko04630 Jak-STAT signaling pathway 1/373 132/7206 0.0151224939479 ko05231 Choline metabolism in cancer 1/373 134/7206 0.0155993864967 ko04621 NOD-like receptor signaling pathway 2/373 157/7206 0.0174260627587 ko04071 Sphingolipid signaling pathway 2/373 162/7206 0.0178244001355 ko04611 Platelet activation 2/373 163/7206 0.0180212598753 ko05167 Kaposi's sarcoma-associated herpesvirus infection 3/373 191/7206 0.0189446973161 ko04912 GnRH signaling pathway 1/373 122/7206 0.0213822555609 ko04750 Inflammatory mediator regulation of TRP channels 1/373 122/7206 0.0213822555609 ko04666 Fc gamma R-mediated phagocytosis 1/373 122/7206 0.0213822555609 ko04660 T cell receptor signaling pathway 1/373 124/7206 0.0217846906074 ko01522 Endocrine resistance 1/373 124/7206 0.0217846906074 ko05145 Toxoplasmosis 1/373 126/7206 0.0224216654745 ko04130 SNARE interactions in vesicular transport 6/373 44/7206 0.0246637542505 ko04932 Non-alcoholic fatty liver disease (NAFLD) 3/373 182/7206 0.0259830763098 ko04070 Phosphatidylinositol signaling system 1/373 112/7206 0.0305975507727 ko04911 Insulin secretion 1/373 117/7206 0.0317160416482 ko04530 Tight junction 5/373 228/7206 0.0333007833228 ko04916 Melanogenesis 2/373 142/7206 0.0344195709539 ko05418 Fluid shear stress and atherosclerosis 3/373 173/7206 0.0355692051834 ko04659 Th17 cell differentiation 1/373 106/7206 0.0442924305288 ko01521 EGFR tyrosine kinase inhibitor resistance 1/373 106/7206 0.0442924305288 ko04933 AGE-RAGE signaling pathway in diabetic complications 2/373 135/7206 0.0482222076229