ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	194/1182	423/7206	3.65372531247e-49
ko04724	Glutamatergic synapse	86/1182	152/7206	3.76074101909e-30
ko05033	Nicotine addiction	46/1182	56/7206	2.4109074834e-27
ko04713	Circadian entrainment	74/1182	136/7206	1.27171578823e-24
ko05032	Morphine addiction	65/1182	110/7206	1.76707686318e-24
ko04727	GABAergic synapse	63/1182	110/7206	9.82665073872e-23
ko04728	Dopaminergic synapse	86/1182	185/7206	2.81534335061e-22
ko04721	Synaptic vesicle cycle	50/1182	80/7206	1.29982689696e-20
ko04725	Cholinergic synapse	75/1182	160/7206	8.07746477683e-20
ko04024	cAMP signaling pathway	103/1182	279/7206	2.44131160231e-17
ko04723	Retrograde endocannabinoid signaling	75/1182	175/7206	4.68397598643e-17
ko04020	Calcium signaling pathway	99/1182	265/7206	6.33508035802e-17
ko04726	Serotonergic synapse	61/1182	137/7206	5.05184077463e-15
ko04742	Taste transduction	37/1182	61/7206	5.720671755e-15
ko04911	Insulin secretion	55/1182	117/7206	6.53059767392e-15
ko04921	Oxytocin signaling pathway	76/1182	209/7206	1.45817236445e-12
ko04970	Salivary secretion	43/1182	95/7206	2.95067273232e-11
ko04261	Adrenergic signaling in cardiomyocytes	72/1182	205/7206	3.69999577549e-11
ko05031	Amphetamine addiction	41/1182	91/7206	1.02279707702e-10
ko04744	Phototransduction	23/1182	36/7206	1.91235510333e-10
ko04720	Long-term potentiation	42/1182	99/7206	6.15529984607e-10
ko03040	Spliceosome	2/1182	145/7206	2.56234225957e-09
ko05203	Viral carcinogenesis	15/1182	277/7206	2.92845819039e-08
ko04022	cGMP-PKG signaling pathway	67/1182	216/7206	6.17410788015e-08
ko04740	Olfactory transduction	33/1182	80/7206	9.71560513386e-08
ko04971	Gastric acid secretion	37/1182	98/7206	2.72350054407e-07
ko05322	Systemic lupus erythematosus	5/1182	151/7206	5.81848051028e-07
ko05168	Herpes simplex infection	8/1182	182/7206	7.28516667795e-07
ko04925	Aldosterone synthesis and secretion	38/1182	105/7206	7.39960538616e-07
ko04060	Cytokine-cytokine receptor interaction	9/1182	191/7206	8.21784238614e-07
ko04360	Axon guidance	68/1182	233/7206	8.27291524279e-07
ko05030	Cocaine addiction	29/1182	73/7206	1.47704538042e-06
ko03013	RNA transport	7/1182	166/7206	1.950884869e-06
ko04070	Phosphatidylinositol signaling system	38/1182	112/7206	4.23024561658e-06
ko04621	NOD-like receptor signaling pathway	7/1182	157/7206	5.51872261467e-06
ko04924	Renin secretion	31/1182	86/7206	1.058102159e-05
ko04972	Pancreatic secretion	37/1182	111/7206	1.20467637774e-05
ko04966	Collecting duct acid secretion	14/1182	26/7206	1.2965553168e-05
ko04010	MAPK signaling pathway	82/1182	321/7206	1.93929674628e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1182	74/7206	2.33112705594e-05
ko04540	Gap junction	40/1182	128/7206	2.94290216777e-05
ko04730	Long-term depression	28/1182	78/7206	3.4734219129e-05
ko04745	Phototransduction - fly	17/1182	38/7206	3.6645406894e-05
ko04514	Cell adhesion molecules (CAMs)	40/1182	130/7206	3.71355011758e-05
ko04964	Proximal tubule bicarbonate reclamation	14/1182	29/7206	6.39335370801e-05
ko04141	Protein processing in endoplasmic reticulum	12/1182	184/7206	7.31421891848e-05
ko04072	Phospholipase D signaling pathway	54/1182	197/7206	7.99114069945e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1182	79/7206	9.26182931454e-05
ko04110	Cell cycle	8/1182	145/7206	9.74000295412e-05
ko04976	Bile secretion	27/1182	80/7206	0.000113596648184
ko04610	Complement and coagulation cascades	2/1182	79/7206	0.00017230284423
ko03008	Ribosome biogenesis in eukaryotes	2/1182	79/7206	0.00017230284423
ko05164	Influenza A	11/1182	167/7206	0.000190977398721
ko05140	Leishmaniasis	2/1182	75/7206	0.00025349271975
ko04612	Antigen processing and presentation	2/1182	77/7206	0.00026219339287
ko04120	Ubiquitin mediated proteolysis	8/1182	138/7206	0.000268066843852
ko04750	Inflammatory mediator regulation of TRP channels	36/1182	122/7206	0.000280868774791
ko05169	Epstein-Barr virus infection	16/1182	206/7206	0.000368583556784
ko04064	NF-kappa B signaling pathway	4/1182	96/7206	0.000409787877073
ko04260	Cardiac muscle contraction	30/1182	98/7206	0.000467262077928
ko04014	Ras signaling pathway	68/1182	279/7206	0.000496938980327
ko05110	Vibrio cholerae infection	21/1182	63/7206	0.00087990260989
ko05414	Dilated cardiomyopathy	32/1182	112/7206	0.00112686076875
ko05205	Proteoglycans in cancer	26/1182	271/7206	0.00141959299675
ko05161	Hepatitis B	14/1182	173/7206	0.00172596470474
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1182	59/7206	0.00232158556999
ko04915	Estrogen signaling pathway	35/1182	131/7206	0.00264363874806
ko05166	HTLV-I infection	30/1182	292/7206	0.00279972220988
ko04923	Regulation of lipolysis in adipocytes	23/1182	77/7206	0.00287160758737
ko04146	Peroxisome	5/1182	89/7206	0.00357254723897
ko03420	Nucleotide excision repair	1/1182	46/7206	0.00441073239519
ko04626	Plant-pathogen interaction	8/1182	18/7206	0.00477235151407
ko04657	IL-17 signaling pathway	5/1182	87/7206	0.00506087381378
ko04930	Type II diabetes mellitus	17/1182	54/7206	0.0051291877015
ko04217	Necroptosis	16/1182	178/7206	0.00543051737877
ko00480	Glutathione metabolism	2/1182	55/7206	0.00566953283933
ko05321	Inflammatory bowel disease (IBD)	2/1182	56/7206	0.00572462290304
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1182	100/7206	0.00623640907158
ko03022	Basal transcription factors	1/1182	44/7206	0.00670289521076
ko04115	p53 signaling pathway	4/1182	74/7206	0.00681730200873
ko05144	Malaria	1/1182	45/7206	0.00704651048804
ko00071	Fatty acid degradation	1/1182	45/7206	0.00704651048804
ko04371	Apelin signaling pathway	43/1182	177/7206	0.007170527716
ko04922	Glucagon signaling pathway	33/1182	128/7206	0.00752676921724
ko04330	Notch signaling pathway	3/1182	62/7206	0.00920459043852
ko04622	RIG-I-like receptor signaling pathway	3/1182	62/7206	0.00920459043852
ko00310	Lysine degradation	4/1182	73/7206	0.0099332224165
ko04710	Circadian rhythm	14/1182	43/7206	0.0109584473897
ko04658	Th1 and Th2 cell differentiation	7/1182	96/7206	0.0121039355944
ko05162	Measles	10/1182	120/7206	0.0127797013316
ko05133	Pertussis	6/1182	87/7206	0.0127805281617
ko05231	Choline metabolism in cancer	33/1182	134/7206	0.013007805993
ko05215	Prostate cancer	9/1182	111/7206	0.0139586002737
ko03410	Base excision repair	1/1182	38/7206	0.0148295111775
ko03018	RNA degradation	6/1182	84/7206	0.0173911241462
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1182	14/7206	0.0175933464232
ko05219	Bladder cancer	2/1182	48/7206	0.0175999903656
ko00240	Pyrimidine metabolism	9/1182	110/7206	0.0186652505977
ko04973	Carbohydrate digestion and absorption	13/1182	42/7206	0.0189393069361
ko00562	Inositol phosphate metabolism	23/1182	89/7206	0.0206190878804
ko04630	Jak-STAT signaling pathway	12/1182	132/7206	0.0233607615697
ko05131	Shigellosis	6/1182	82/7206	0.0236296637809
ko04214	Apoptosis - fly	5/1182	72/7206	0.0250506867042
ko04640	Hematopoietic cell lineage	4/1182	64/7206	0.0262294632533
ko00280	Valine, leucine and isoleucine degradation	3/1182	54/7206	0.0263822102011
ko04510	Focal adhesion	27/1182	240/7206	0.0266213857449
ko04270	Vascular smooth muscle contraction	36/1182	154/7206	0.0270094962482
ko04960	Aldosterone-regulated sodium reabsorption	12/1182	41/7206	0.0335412241832
ko04113	Meiosis - yeast	5/1182	70/7206	0.0341910977748
ko00330	Arginine and proline metabolism	4/1182	61/7206	0.0361601258855
ko00590	Arachidonic acid metabolism	3/1182	52/7206	0.0372945469792
ko05145	Toxoplasmosis	12/1182	126/7206	0.0381774043636
ko04722	Neurotrophin signaling pathway	36/1182	160/7206	0.0400219119172
ko03320	PPAR signaling pathway	5/1182	69/7206	0.0477414273922
ko04711	Circadian rhythm - fly	5/1182	13/7206	0.0480108336377