ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	191/1218	423/7206	5.40212376227e-45
ko04724	Glutamatergic synapse	90/1218	152/7206	1.3573398524e-32
ko05033	Nicotine addiction	48/1218	56/7206	1.40734093937e-29
ko04727	GABAergic synapse	67/1218	110/7206	1.67385591152e-25
ko05032	Morphine addiction	66/1218	110/7206	1.32257052056e-24
ko04713	Circadian entrainment	73/1218	136/7206	5.32551464154e-23
ko04721	Synaptic vesicle cycle	52/1218	80/7206	6.26747989456e-22
ko04728	Dopaminergic synapse	84/1218	185/7206	4.49549751154e-20
ko04725	Cholinergic synapse	76/1218	160/7206	1.071532865e-19
ko04723	Retrograde endocannabinoid signaling	77/1218	175/7206	1.65690951767e-17
ko04742	Taste transduction	38/1218	61/7206	1.90339994327e-15
ko04024	cAMP signaling pathway	101/1218	279/7206	2.56348758407e-15
ko04744	Phototransduction	27/1218	36/7206	2.20092951489e-14
ko04911	Insulin secretion	54/1218	117/7206	1.10246652217e-13
ko04020	Calcium signaling pathway	93/1218	265/7206	2.8418439826e-13
ko04921	Oxytocin signaling pathway	78/1218	209/7206	6.7527221938e-13
ko04726	Serotonergic synapse	57/1218	137/7206	4.90035251013e-12
ko04720	Long-term potentiation	45/1218	99/7206	2.45374755839e-11
ko05031	Amphetamine addiction	42/1218	91/7206	6.22696349594e-11
ko03040	Spliceosome	1/1218	145/7206	7.27798312459e-11
ko04261	Adrenergic signaling in cardiomyocytes	71/1218	205/7206	5.07115425773e-10
ko04740	Olfactory transduction	37/1218	80/7206	8.05091744138e-10
ko04970	Salivary secretion	39/1218	95/7206	1.86169622929e-08
ko05203	Viral carcinogenesis	16/1218	277/7206	2.76162320386e-08
ko04060	Cytokine-cytokine receptor interaction	8/1218	191/7206	7.46895630779e-08
ko05168	Herpes simplex infection	8/1218	182/7206	3.31335039977e-07
ko04966	Collecting duct acid secretion	16/1218	26/7206	3.93802146284e-07
ko04360	Axon guidance	70/1218	233/7206	4.50507586347e-07
ko04971	Gastric acid secretion	37/1218	98/7206	7.90938917212e-07
ko05030	Cocaine addiction	30/1218	73/7206	7.96112620178e-07
ko03013	RNA transport	7/1218	166/7206	8.71533969382e-07
ko04925	Aldosterone synthesis and secretion	38/1218	105/7206	2.11553180037e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1218	74/7206	4.87189341285e-06
ko05322	Systemic lupus erythematosus	7/1218	151/7206	7.75915919939e-06
ko04120	Ubiquitin mediated proteolysis	6/1218	138/7206	9.29320399483e-06
ko04022	cGMP-PKG signaling pathway	62/1218	216/7206	1.17434266274e-05
ko04621	NOD-like receptor signaling pathway	8/1218	157/7206	1.20145677427e-05
ko04610	Complement and coagulation cascades	1/1218	79/7206	1.26184854707e-05
ko04514	Cell adhesion molecules (CAMs)	42/1218	130/7206	1.45041529519e-05
ko05164	Influenza A	10/1218	167/7206	3.67721225581e-05
ko04064	NF-kappa B signaling pathway	3/1218	96/7206	4.73617040411e-05
ko05110	Vibrio cholerae infection	24/1218	63/7206	5.30796687982e-05
ko04745	Phototransduction - fly	17/1218	38/7206	5.45367297107e-05
ko04924	Renin secretion	30/1218	86/7206	5.76032758755e-05
ko04110	Cell cycle	8/1218	145/7206	6.92906625478e-05
ko04976	Bile secretion	28/1218	80/7206	7.06215218316e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1218	79/7206	0.000110201194093
ko04141	Protein processing in endoplasmic reticulum	13/1218	184/7206	0.000129578504958
ko05205	Proteoglycans in cancer	24/1218	271/7206	0.000135965909429
ko04072	Phospholipase D signaling pathway	54/1218	197/7206	0.000157058021668
ko04972	Pancreatic secretion	35/1218	111/7206	0.000161885203705
ko04070	Phosphatidylinositol signaling system	35/1218	112/7206	0.000176013485259
ko04010	MAPK signaling pathway	80/1218	321/7206	0.000177497125193
ko04730	Long-term depression	27/1218	78/7206	0.000178873028964
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1218	79/7206	0.0001983335554
ko05140	Leishmaniasis	2/1218	75/7206	0.000255515291561
ko04540	Gap junction	38/1218	128/7206	0.00029737430292
ko05169	Epstein-Barr virus infection	17/1218	206/7206	0.000436276552057
ko05414	Dilated cardiomyopathy	34/1218	112/7206	0.000490691112992
ko04915	Estrogen signaling pathway	38/1218	131/7206	0.000547469305308
ko04146	Peroxisome	4/1218	89/7206	0.000554357312984
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1218	14/7206	0.00074749508096
ko04750	Inflammatory mediator regulation of TRP channels	35/1218	122/7206	0.000937931525652
ko05161	Hepatitis B	14/1218	173/7206	0.000955369721592
ko04612	Antigen processing and presentation	3/1218	77/7206	0.00104761206473
ko04014	Ras signaling pathway	68/1218	279/7206	0.00108513029669
ko04626	Plant-pathogen interaction	9/1218	18/7206	0.00123590354312
ko05162	Measles	8/1218	120/7206	0.00129603984057
ko04964	Proximal tubule bicarbonate reclamation	12/1218	29/7206	0.00159078801335
ko04260	Cardiac muscle contraction	29/1218	98/7206	0.00159970101579
ko00240	Pyrimidine metabolism	7/1218	110/7206	0.0018444951723
ko04214	Apoptosis - fly	3/1218	72/7206	0.00220096628196
ko05321	Inflammatory bowel disease (IBD)	2/1218	56/7206	0.00377013463863
ko04371	Apelin signaling pathway	45/1218	177/7206	0.00420222967575
ko03022	Basal transcription factors	1/1218	44/7206	0.00430048174493
ko05144	Malaria	1/1218	45/7206	0.00433005991708
ko00071	Fatty acid degradation	1/1218	45/7206	0.00433005991708
ko03420	Nucleotide excision repair	1/1218	46/7206	0.00453938677718
ko03018	RNA degradation	5/1218	84/7206	0.00488581283485
ko04923	Regulation of lipolysis in adipocytes	23/1218	77/7206	0.00518013957831
ko05145	Toxoplasmosis	10/1218	126/7206	0.00542444461311
ko00480	Glutathione metabolism	2/1218	55/7206	0.0057155053329
ko04640	Hematopoietic cell lineage	3/1218	64/7206	0.0064424797916
ko00310	Lysine degradation	4/1218	73/7206	0.00680916177392
ko05166	HTLV-I infection	33/1218	292/7206	0.00834969265787
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1218	59/7206	0.00837126414569
ko00330	Arginine and proline metabolism	3/1218	61/7206	0.00910015286158
ko04657	IL-17 signaling pathway	6/1218	87/7206	0.0091539262728
ko05133	Pertussis	6/1218	87/7206	0.0091539262728
ko03320	PPAR signaling pathway	4/1218	69/7206	0.00938496656383
ko04622	RIG-I-like receptor signaling pathway	3/1218	62/7206	0.00942730225438
ko05206	MicroRNAs in cancer	18/1218	177/7206	0.0144477874194
ko00630	Glyoxylate and dicarboxylate metabolism	1/1218	38/7206	0.0148465405932
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1218	182/7206	0.0161148923814
ko00290	Valine, leucine and isoleucine biosynthesis	3/1218	4/7206	0.0168378846
ko05131	Shigellosis	6/1218	82/7206	0.0170979583201
ko04115	p53 signaling pathway	5/1218	74/7206	0.0181704486489
ko05418	Fluid shear stress and atherosclerosis	18/1218	173/7206	0.0181986232464
ko04668	TNF signaling pathway	11/1218	120/7206	0.0194972608339
ko04210	Apoptosis	19/1218	180/7206	0.0202228268147
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1218	100/7206	0.0213469634907
ko00860	Porphyrin and chlorophyll metabolism	1/1218	34/7206	0.0218517689929
ko04350	TGF-beta signaling pathway	9/1218	103/7206	0.0239178967819
ko05120	Epithelial cell signaling in Helicobacter pylori infection	24/1218	92/7206	0.0242375994474
ko04217	Necroptosis	19/1218	178/7206	0.0253705901415
ko04630	Jak-STAT signaling pathway	13/1218	132/7206	0.0260022713427
ko00590	Arachidonic acid metabolism	3/1218	52/7206	0.0260171064655
ko04658	Th1 and Th2 cell differentiation	8/1218	96/7206	0.0270064454392
ko04062	Chemokine signaling pathway	46/1218	201/7206	0.0276279794073
ko04912	GnRH signaling pathway	30/1218	122/7206	0.0277861450504
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1218	15/7206	0.0290570540447
ko01524	Platinum drug resistance	6/1218	76/7206	0.0313512826795
ko00562	Inositol phosphate metabolism	23/1218	89/7206	0.031641590065
ko04922	Glucagon signaling pathway	31/1218	128/7206	0.0316692067213
ko00380	Tryptophan metabolism	3/1218	50/7206	0.0366318872033
ko04710	Circadian rhythm	13/1218	43/7206	0.0379125456044
ko04918	Thyroid hormone synthesis	22/1218	86/7206	0.0412640628051
ko05222	Small cell lung cancer	8/1218	89/7206	0.0457703626485
ko05320	Autoimmune thyroid disease	1/1218	29/7206	0.0485938187758