ko pathway ratio_in_study ratio_in_pop p_value ko04668 TNF signaling pathway 22/262 120/7206 2.32849993878e-10 ko04210 Apoptosis 23/262 180/7206 1.19449585092e-07 ko04621 NOD-like receptor signaling pathway 20/262 157/7206 8.66962507857e-07 ko04217 Necroptosis 21/262 178/7206 1.64865016361e-06 ko04657 IL-17 signaling pathway 14/262 87/7206 2.49897948191e-06 ko00512 Mucin type O-glycan biosynthesis 8/262 29/7206 6.06143667969e-06 ko04530 Tight junction 22/262 228/7206 2.51391641327e-05 ko00511 Other glycan degradation 7/262 26/7206 2.8162295284e-05 ko04660 T cell receptor signaling pathway 15/262 124/7206 3.91084430355e-05 ko04064 NF-kappa B signaling pathway 13/262 96/7206 3.91356477195e-05 ko05161 Hepatitis B 18/262 173/7206 5.21918692809e-05 ko04380 Osteoclast differentiation 15/262 134/7206 9.67480747292e-05 ko05160 Hepatitis C 16/262 153/7206 0.000128609601401 ko04666 Fc gamma R-mediated phagocytosis 13/262 122/7206 0.000458546440906 ko00590 Arachidonic acid metabolism 8/262 52/7206 0.000514532604254 ko04060 Cytokine-cytokine receptor interaction 17/262 191/7206 0.000553920711654 ko04623 Cytosolic DNA-sensing pathway 7/262 41/7206 0.00060341525131 ko04722 Neurotrophin signaling pathway 15/262 160/7206 0.000680230528168 ko05100 Bacterial invasion of epithelial cells 11/262 99/7206 0.00087839842621 ko04214 Apoptosis - fly 9/262 72/7206 0.00110774099835 ko04142 Lysosome 14/262 151/7206 0.00113886415997 ko04670 Leukocyte transendothelial migration 14/262 151/7206 0.00113886415997 ko04662 B cell receptor signaling pathway 10/262 88/7206 0.00125848037108 ko04115 p53 signaling pathway 9/262 74/7206 0.0013503843691 ko01524 Platinum drug resistance 9/262 76/7206 0.0016341463527 ko04622 RIG-I-like receptor signaling pathway 8/262 62/7206 0.00168991213963 ko05215 Prostate cancer 11/262 111/7206 0.00224656252524 ko05131 Shigellosis 9/262 82/7206 0.00278211323586 ko05146 Amoebiasis 10/262 99/7206 0.00306275067004 ko05152 Tuberculosis 15/262 187/7206 0.00414339002106 ko04912 GnRH signaling pathway 11/262 122/7206 0.00469051902231 ko04750 Inflammatory mediator regulation of TRP channels 11/262 122/7206 0.00469051902231 ko05167 Kaposi's sarcoma-associated herpesvirus infection 15/262 191/7206 0.00473758757206 ko05206 MicroRNAs in cancer 14/262 177/7206 0.00630047810473 ko04215 Apoptosis - multiple species 6/262 47/7206 0.00669779039498 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 8/262 79/7206 0.00767934820717 ko04658 Th1 and Th2 cell differentiation 9/262 96/7206 0.00793010886038 ko04624 Toll and Imd signaling pathway 6/262 49/7206 0.00821252767967 ko05200 Pathways in cancer 29/262 492/7206 0.00850031903512 ko04611 Platelet activation 13/262 163/7206 0.00850102242899 ko00531 Glycosaminoglycan degradation 4/262 23/7206 0.00876194899997 ko04933 AGE-RAGE signaling pathway in diabetic complications 11/262 135/7206 0.00989564990769 ko05212 Pancreatic cancer 8/262 83/7206 0.0102569036294 ko04620 Toll-like receptor signaling pathway 9/262 100/7206 0.0102660596943 ko00520 Amino sugar and nucleotide sugar metabolism 6/262 55/7206 0.0142171893055 ko01522 Endocrine resistance 10/262 124/7206 0.0145677569869 ko05222 Small cell lung cancer 8/262 89/7206 0.0152571714252 ko04144 Endocytosis 21/262 342/7206 0.0169398131714 ko04931 Insulin resistance 11/262 137/7206 0.0169430613259 ko04071 Sphingolipid signaling pathway 12/262 162/7206 0.0170662358411 ko00565 Ether lipid metabolism 5/262 42/7206 0.0173345903994 ko05014 Amyotrophic lateral sclerosis (ALS) 7/262 74/7206 0.0175203156388 ko04962 Vasopressin-regulated water reabsorption 6/262 58/7206 0.0181451475128 ko05120 Epithelial cell signaling in Helicobacter pylori infection 8/262 92/7206 0.0183318873644 ko05164 Influenza A 12/262 167/7206 0.0202718571456 ko04370 VEGF signaling pathway 7/262 77/7206 0.0213725413006 ko05132 Salmonella infection 8/262 98/7206 0.0257707040833 ko05142 Chagas disease (American trypanosomiasis) 10/262 130/7206 0.027456950102 ko04915 Estrogen signaling pathway 10/262 131/7206 0.0281395337994 ko00603 Glycosphingolipid biosynthesis - globo and isoglobo series 2/262 8/7206 0.031899966763 ko03013 RNA transport 1/262 166/7206 0.0323285441355 ko04726 Serotonergic synapse 10/262 137/7206 0.0331898969823 ko05220 Chronic myeloid leukemia 7/262 85/7206 0.0344309627304 ko00540 Lipopolysaccharide biosynthesis 1/262 1/7206 0.036358590064 ko04011 MAPK signaling pathway - yeast 5/262 53/7206 0.0424818202817 ko05322 Systemic lupus erythematosus 1/262 151/7206 0.0453379753398 ko05202 Transcriptional misregulation in cancer 12/262 188/7206 0.0481112942855