ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	185/1079	423/7206	2.6819909029e-49
ko04724	Glutamatergic synapse	84/1079	152/7206	1.97059361099e-31
ko05033	Nicotine addiction	43/1079	56/7206	4.37612226934e-25
ko05032	Morphine addiction	61/1079	110/7206	3.5036476516e-23
ko04713	Circadian entrainment	67/1079	136/7206	1.64216773987e-21
ko04728	Dopaminergic synapse	80/1079	185/7206	6.32753937141e-21
ko04721	Synaptic vesicle cycle	48/1079	80/7206	1.76873701989e-20
ko04727	GABAergic synapse	57/1079	110/7206	8.04479335303e-20
ko04725	Cholinergic synapse	69/1079	160/7206	4.14496037924e-18
ko04723	Retrograde endocannabinoid signaling	70/1079	175/7206	3.01546300834e-16
ko04020	Calcium signaling pathway	92/1079	265/7206	3.96786572597e-16
ko04024	cAMP signaling pathway	94/1079	279/7206	1.39684832313e-15
ko04726	Serotonergic synapse	58/1079	137/7206	5.74661005759e-15
ko04911	Insulin secretion	52/1079	117/7206	1.36386220056e-14
ko04921	Oxytocin signaling pathway	73/1079	209/7206	3.24993198045e-13
ko04742	Taste transduction	32/1079	61/7206	7.18889546882e-12
ko05031	Amphetamine addiction	39/1079	91/7206	1.11897054061e-10
ko04720	Long-term potentiation	40/1079	99/7206	5.60115229865e-10
ko04970	Salivary secretion	38/1079	95/7206	2.13129132032e-09
ko03040	Spliceosome	1/1079	145/7206	2.18277558061e-09
ko04261	Adrenergic signaling in cardiomyocytes	63/1079	205/7206	6.49204597798e-09
ko04744	Phototransduction	20/1079	36/7206	1.80402143005e-08
ko03010	Ribosome	1/1079	129/7206	2.81158571788e-08
ko04925	Aldosterone synthesis and secretion	38/1079	105/7206	8.90013465784e-08
ko05322	Systemic lupus erythematosus	3/1079	151/7206	1.03799664686e-07
ko04971	Gastric acid secretion	35/1079	98/7206	3.74266132952e-07
ko05168	Herpes simplex infection	6/1079	182/7206	4.35250821641e-07
ko05203	Viral carcinogenesis	15/1079	277/7206	7.07263391482e-07
ko05030	Cocaine addiction	27/1079	73/7206	2.82241186213e-06
ko04972	Pancreatic secretion	36/1079	111/7206	2.82690253767e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1079	74/7206	3.82002522629e-06
ko04966	Collecting duct acid secretion	14/1079	26/7206	4.32404263422e-06
ko04120	Ubiquitin mediated proteolysis	4/1079	138/7206	5.20461087371e-06
ko04514	Cell adhesion molecules (CAMs)	39/1079	130/7206	9.69976001771e-06
ko04621	NOD-like receptor signaling pathway	6/1079	157/7206	1.18820558214e-05
ko03013	RNA transport	7/1079	166/7206	1.30477303308e-05
ko05164	Influenza A	7/1079	167/7206	1.33869418229e-05
ko04360	Axon guidance	60/1079	233/7206	1.39097177088e-05
ko04730	Long-term depression	27/1079	78/7206	1.48836003589e-05
ko04010	MAPK signaling pathway	76/1079	321/7206	2.73220709579e-05
ko04750	Inflammatory mediator regulation of TRP channels	36/1079	122/7206	3.16964878685e-05
ko04022	cGMP-PKG signaling pathway	55/1079	216/7206	4.07332255635e-05
ko04070	Phosphatidylinositol signaling system	34/1079	112/7206	4.07435366915e-05
ko04540	Gap junction	37/1079	128/7206	4.5754784663e-05
ko04745	Phototransduction - fly	16/1079	38/7206	4.87086378949e-05
ko04141	Protein processing in endoplasmic reticulum	10/1079	184/7206	6.01250206439e-05
ko04612	Antigen processing and presentation	1/1079	77/7206	7.99613006632e-05
ko04060	Cytokine-cytokine receptor interaction	11/1079	191/7206	8.33235281735e-05
ko04740	Olfactory transduction	26/1079	80/7206	9.2488235937e-05
ko04110	Cell cycle	7/1079	145/7206	0.000145793839677
ko04014	Ras signaling pathway	65/1079	279/7206	0.000209266215032
ko04072	Phospholipase D signaling pathway	49/1079	197/7206	0.000231548701718
ko05110	Vibrio cholerae infection	21/1079	63/7206	0.000236563316604
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	24/1079	79/7206	0.000399771224066
ko04964	Proximal tubule bicarbonate reclamation	12/1079	29/7206	0.000522328566878
ko03008	Ribosome biogenesis in eukaryotes	2/1079	79/7206	0.000646754663349
ko04976	Bile secretion	24/1079	80/7206	0.000692586647632
ko05414	Dilated cardiomyopathy	30/1079	112/7206	0.00114745628763
ko05161	Hepatitis B	12/1079	173/7206	0.00163622977637
ko04924	Renin secretion	24/1079	86/7206	0.00195767430474
ko05169	Epstein-Barr virus infection	16/1079	206/7206	0.00205197129758
ko04260	Cardiac muscle contraction	26/1079	98/7206	0.00251538336378
ko04146	Peroxisome	4/1079	89/7206	0.00259427001949
ko04626	Plant-pathogen interaction	8/1079	18/7206	0.00265252107759
ko05162	Measles	7/1079	120/7206	0.00277010902421
ko04064	NF-kappa B signaling pathway	5/1079	96/7206	0.0038251299779
ko04710	Circadian rhythm	14/1079	43/7206	0.00382890198341
ko04915	Estrogen signaling pathway	32/1079	131/7206	0.00412539811448
ko05166	HTLV-I infection	27/1079	292/7206	0.00426987338709
ko05140	Leishmaniasis	3/1079	75/7206	0.00493129370793
ko05205	Proteoglycans in cancer	25/1079	271/7206	0.00538941272436
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1079	59/7206	0.00540956475938
ko04330	Notch signaling pathway	2/1079	62/7206	0.00625854877896
ko04630	Jak-STAT signaling pathway	9/1079	132/7206	0.00632850530723
ko04916	Melanogenesis	33/1079	142/7206	0.00849043735638
ko03022	Basal transcription factors	1/1079	44/7206	0.010535539131
ko04217	Necroptosis	15/1079	178/7206	0.0105630771472
ko05144	Malaria	1/1079	45/7206	0.0105695351556
ko00071	Fatty acid degradation	1/1079	45/7206	0.0105695351556
ko03420	Nucleotide excision repair	1/1079	46/7206	0.0109096517447
ko05145	Toxoplasmosis	9/1079	126/7206	0.0111856756508
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1079	14/7206	0.0113518576473
ko04922	Glucagon signaling pathway	30/1079	128/7206	0.0116876743426
ko04015	Rap1 signaling pathway	57/1079	278/7206	0.0125882496695
ko04960	Aldosterone-regulated sodium reabsorption	12/1079	41/7206	0.0154837082514
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1079	100/7206	0.0157093414516
ko04270	Vascular smooth muscle contraction	34/1079	154/7206	0.0162073157208
ko04510	Focal adhesion	23/1079	240/7206	0.0164323948175
ko04371	Apelin signaling pathway	38/1079	177/7206	0.0185300703326
ko00280	Valine, leucine and isoleucine degradation	2/1079	54/7206	0.0193147010174
ko04622	RIG-I-like receptor signaling pathway	3/1079	62/7206	0.019604208353
ko04214	Apoptosis - fly	4/1079	72/7206	0.019720274257
ko00310	Lysine degradation	4/1079	73/7206	0.0198424292834
ko04912	GnRH signaling pathway	28/1079	122/7206	0.0202415700541
ko00240	Pyrimidine metabolism	8/1079	110/7206	0.0212652752328
ko04114	Oocyte meiosis	31/1079	139/7206	0.0216792366351
ko04923	Regulation of lipolysis in adipocytes	19/1079	77/7206	0.0233863889826
ko05222	Small cell lung cancer	6/1079	89/7206	0.0246859285841
ko04610	Complement and coagulation cascades	5/1079	79/7206	0.0262063122905
ko04658	Th1 and Th2 cell differentiation	7/1079	96/7206	0.0305645096996
ko04930	Type II diabetes mellitus	14/1079	54/7206	0.0331905745295
ko04657	IL-17 signaling pathway	6/1079	87/7206	0.0332875691039
ko05133	Pertussis	6/1079	87/7206	0.0332875691039
ko03410	Base excision repair	1/1079	38/7206	0.0361171198403
ko05321	Inflammatory bowel disease (IBD)	3/1079	56/7206	0.0387466122245
ko05219	Bladder cancer	2/1079	48/7206	0.0392908025505
ko05120	Epithelial cell signaling in Helicobacter pylori infection	21/1079	92/7206	0.0393036059292
ko05206	MicroRNAs in cancer	17/1079	177/7206	0.0424782641961
ko03018	RNA degradation	6/1079	84/7206	0.0444859908214
ko04115	p53 signaling pathway	5/1079	74/7206	0.0482753727245
ko04973	Carbohydrate digestion and absorption	11/1079	42/7206	0.0499682894999