ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	185/1179	423/7206	3.03297296379e-43
ko04724	Glutamatergic synapse	87/1179	152/7206	4.28787133364e-31
ko05033	Nicotine addiction	48/1179	56/7206	3.00837502999e-30
ko05032	Morphine addiction	68/1179	110/7206	2.73373273141e-27
ko04727	GABAergic synapse	66/1179	110/7206	1.92460978785e-25
ko04713	Circadian entrainment	73/1179	136/7206	6.87800822941e-24
ko04725	Cholinergic synapse	77/1179	160/7206	2.87181849885e-21
ko04728	Dopaminergic synapse	84/1179	185/7206	5.06351642921e-21
ko04721	Synaptic vesicle cycle	49/1179	80/7206	9.9832629167e-20
ko04723	Retrograde endocannabinoid signaling	78/1179	175/7206	5.40981678695e-19
ko04024	cAMP signaling pathway	99/1179	279/7206	2.12905672409e-15
ko04911	Insulin secretion	55/1179	117/7206	5.83360920373e-15
ko04744	Phototransduction	27/1179	36/7206	9.57319699714e-15
ko04742	Taste transduction	36/1179	61/7206	4.12785104264e-14
ko04020	Calcium signaling pathway	90/1179	265/7206	9.65455018761e-13
ko04726	Serotonergic synapse	57/1179	137/7206	1.21900947002e-12
ko04921	Oxytocin signaling pathway	76/1179	209/7206	1.36677824434e-12
ko03040	Spliceosome	1/1179	145/7206	1.9372053751e-10
ko04261	Adrenergic signaling in cardiomyocytes	70/1179	205/7206	2.83334123443e-10
ko05031	Amphetamine addiction	40/1179	91/7206	4.0280229025e-10
ko04720	Long-term potentiation	42/1179	99/7206	5.67554951546e-10
ko04740	Olfactory transduction	34/1179	80/7206	2.37611154462e-08
ko04925	Aldosterone synthesis and secretion	40/1179	105/7206	6.3480278033e-08
ko04970	Salivary secretion	37/1179	95/7206	1.29876059552e-07
ko04360	Axon guidance	67/1179	233/7206	1.35224282482e-06
ko05030	Cocaine addiction	29/1179	73/7206	1.39973948452e-06
ko03013	RNA transport	7/1179	166/7206	1.92146415955e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1179	74/7206	1.94738461772e-06
ko04971	Gastric acid secretion	35/1179	98/7206	2.7203383074e-06
ko05203	Viral carcinogenesis	19/1179	277/7206	2.75885964696e-06
ko05322	Systemic lupus erythematosus	6/1179	151/7206	3.33458481374e-06
ko05168	Herpes simplex infection	10/1179	182/7206	1.00956854769e-05
ko04070	Phosphatidylinositol signaling system	37/1179	112/7206	1.31667889194e-05
ko05164	Influenza A	9/1179	167/7206	1.89664089179e-05
ko04120	Ubiquitin mediated proteolysis	6/1179	138/7206	2.06302448597e-05
ko04072	Phospholipase D signaling pathway	55/1179	197/7206	3.36248432456e-05
ko04745	Phototransduction - fly	17/1179	38/7206	3.54251604387e-05
ko04514	Cell adhesion molecules (CAMs)	40/1179	130/7206	3.57243877638e-05
ko04060	Cytokine-cytokine receptor interaction	12/1179	191/7206	3.92837928513e-05
ko04010	MAPK signaling pathway	80/1179	321/7206	5.47098672589e-05
ko04966	Collecting duct acid secretion	13/1179	26/7206	7.18918703286e-05
ko04621	NOD-like receptor signaling pathway	9/1179	157/7206	7.24716000007e-05
ko04972	Pancreatic secretion	35/1179	111/7206	7.41079566404e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1179	79/7206	8.9435226858e-05
ko04022	cGMP-PKG signaling pathway	57/1179	216/7206	0.000162632924592
ko03008	Ribosome biogenesis in eukaryotes	2/1179	79/7206	0.000171834110392
ko04730	Long-term depression	26/1179	78/7206	0.00027783606809
ko04110	Cell cycle	9/1179	145/7206	0.000375245161279
ko05140	Leishmaniasis	2/1179	75/7206	0.000398192966705
ko04064	NF-kappa B signaling pathway	4/1179	96/7206	0.000407459463057
ko04014	Ras signaling pathway	68/1179	279/7206	0.000486962100283
ko04915	Estrogen signaling pathway	37/1179	131/7206	0.000493562303421
ko04141	Protein processing in endoplasmic reticulum	14/1179	184/7206	0.000557449950809
ko05110	Vibrio cholerae infection	21/1179	63/7206	0.00086018135709
ko04260	Cardiac muscle contraction	29/1179	98/7206	0.000864911069564
ko04626	Plant-pathogen interaction	9/1179	18/7206	0.000969074371819
ko04610	Complement and coagulation cascades	3/1179	79/7206	0.00105926092451
ko05414	Dilated cardiomyopathy	32/1179	112/7206	0.0011053227445
ko04924	Renin secretion	26/1179	86/7206	0.00111199795885
ko04976	Bile secretion	25/1179	80/7206	0.00111778521211
ko04750	Inflammatory mediator regulation of TRP channels	34/1179	122/7206	0.0011837274752
ko04540	Gap junction	35/1179	128/7206	0.00153714100261
ko05161	Hepatitis B	14/1179	173/7206	0.00173112999491
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1179	59/7206	0.00226976545942
ko04930	Type II diabetes mellitus	18/1179	54/7206	0.00236549218672
ko05162	Measles	8/1179	120/7206	0.00254484313279
ko00240	Pyrimidine metabolism	7/1179	110/7206	0.00257677285972
ko05205	Proteoglycans in cancer	27/1179	271/7206	0.00324920668154
ko04146	Peroxisome	5/1179	89/7206	0.00356928359391
ko05169	Epstein-Barr virus infection	19/1179	206/7206	0.00396160657093
ko04964	Proximal tubule bicarbonate reclamation	11/1179	29/7206	0.00425802329038
ko03420	Nucleotide excision repair	1/1179	46/7206	0.00441431502652
ko04612	Antigen processing and presentation	4/1179	77/7206	0.004845468926
ko00480	Glutathione metabolism	2/1179	55/7206	0.00568645594257
ko03022	Basal transcription factors	1/1179	44/7206	0.00669353862218
ko04115	p53 signaling pathway	4/1179	74/7206	0.00682638292288
ko00071	Fatty acid degradation	1/1179	45/7206	0.00700833274977
ko04923	Regulation of lipolysis in adipocytes	22/1179	77/7206	0.00752408124968
ko04622	RIG-I-like receptor signaling pathway	3/1179	62/7206	0.00922078825418
ko05166	HTLV-I infection	32/1179	292/7206	0.00962062332772
ko00310	Lysine degradation	4/1179	73/7206	0.0098847932297
ko04510	Focal adhesion	25/1179	240/7206	0.00989447662454
ko04710	Circadian rhythm	14/1179	43/7206	0.0108840457059
ko04711	Circadian rhythm - fly	6/1179	13/7206	0.0114983133139
ko04658	Th1 and Th2 cell differentiation	7/1179	96/7206	0.012123159832
ko00590	Arachidonic acid metabolism	2/1179	52/7206	0.0126596852839
ko05133	Pertussis	6/1179	87/7206	0.0127958560538
ko03320	PPAR signaling pathway	4/1179	69/7206	0.0134721798092
ko00330	Arginine and proline metabolism	3/1179	61/7206	0.0135051608289
ko00630	Glyoxylate and dicarboxylate metabolism	1/1179	38/7206	0.0148577829171
ko03410	Base excision repair	1/1179	38/7206	0.0148577829171
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1179	14/7206	0.0173825035504
ko03018	RNA degradation	6/1179	84/7206	0.0174280546737
ko04371	Apelin signaling pathway	41/1179	177/7206	0.0175423006734
ko05145	Toxoplasmosis	11/1179	126/7206	0.0201523411196
ko00562	Inositol phosphate metabolism	23/1179	89/7206	0.0203543624729
ko05131	Shigellosis	6/1179	82/7206	0.0236275476723
ko04214	Apoptosis - fly	5/1179	72/7206	0.0251137191374
ko04640	Hematopoietic cell lineage	4/1179	64/7206	0.0262110446109
ko00280	Valine, leucine and isoleucine degradation	3/1179	54/7206	0.0264269199152
ko04918	Thyroid hormone synthesis	22/1179	86/7206	0.0268718219438
ko05321	Inflammatory bowel disease (IBD)	3/1179	56/7206	0.0273078517589
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1179	100/7206	0.0281216890209
ko04210	Apoptosis	19/1179	180/7206	0.0319274631598
ko00860	Porphyrin and chlorophyll metabolism	1/1179	34/7206	0.0335440934315
ko04912	GnRH signaling pathway	29/1179	122/7206	0.0348151006656
ko00500	Starch and sucrose metabolism	1/1179	35/7206	0.0350654975781
ko05202	Transcriptional misregulation in cancer	20/1179	188/7206	0.0352283339921
ko04330	Notch signaling pathway	4/1179	62/7206	0.0366541294401
ko04922	Glucagon signaling pathway	30/1179	128/7206	0.0393259523595
ko04722	Neurotrophin signaling pathway	36/1179	160/7206	0.0396056368382
ko04217	Necroptosis	19/1179	178/7206	0.0396479980805
ko04657	IL-17 signaling pathway	7/1179	87/7206	0.0396645022921
ko04630	Jak-STAT signaling pathway	13/1179	132/7206	0.0428856847272
ko05231	Choline metabolism in cancer	31/1179	134/7206	0.04397928276
ko00230	Purine metabolism	42/1179	194/7206	0.0488352928468