ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	187/1105	423/7206	4.75374144184e-49
ko04724	Glutamatergic synapse	88/1105	152/7206	3.31528201953e-34
ko05033	Nicotine addiction	46/1105	56/7206	1.15608054645e-28
ko05032	Morphine addiction	64/1105	110/7206	2.82840799556e-25
ko04713	Circadian entrainment	72/1105	136/7206	7.41732054784e-25
ko04727	GABAergic synapse	61/1105	110/7206	1.27180401821e-22
ko04728	Dopaminergic synapse	83/1105	185/7206	2.92760182905e-22
ko04721	Synaptic vesicle cycle	48/1105	80/7206	4.98142441391e-20
ko04725	Cholinergic synapse	71/1105	160/7206	7.43883211119e-19
ko04723	Retrograde endocannabinoid signaling	75/1105	175/7206	8.85439353941e-19
ko04020	Calcium signaling pathway	93/1105	265/7206	4.64795730561e-16
ko04024	cAMP signaling pathway	95/1105	279/7206	2.72627248755e-15
ko04726	Serotonergic synapse	59/1105	137/7206	3.93848968873e-15
ko04911	Insulin secretion	52/1105	117/7206	3.69919042219e-14
ko04921	Oxytocin signaling pathway	75/1105	209/7206	1.11148861647e-13
ko04742	Taste transduction	34/1105	61/7206	3.05345709185e-13
ko05031	Amphetamine addiction	41/1105	91/7206	1.13766559254e-11
ko04720	Long-term potentiation	43/1105	99/7206	1.60317154285e-11
ko04744	Phototransduction	23/1105	36/7206	4.67817956573e-11
ko04970	Salivary secretion	39/1105	95/7206	1.07681432372e-09
ko04261	Adrenergic signaling in cardiomyocytes	64/1105	205/7206	5.69671744206e-09
ko04925	Aldosterone synthesis and secretion	40/1105	105/7206	8.82026862353e-09
ko04971	Gastric acid secretion	38/1105	98/7206	1.17654523876e-08
ko03040	Spliceosome	2/1105	145/7206	1.63370162753e-08
ko03010	Ribosome	1/1105	129/7206	1.75327936611e-08
ko05030	Cocaine addiction	29/1105	73/7206	3.47855099193e-07
ko04730	Long-term depression	30/1105	78/7206	5.03056285378e-07
ko04966	Collecting duct acid secretion	15/1105	26/7206	8.08805784902e-07
ko05168	Herpes simplex infection	7/1105	182/7206	1.03631786047e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1105	74/7206	1.77104720291e-06
ko05322	Systemic lupus erythematosus	5/1105	151/7206	3.0868925253e-06
ko04740	Olfactory transduction	29/1105	80/7206	4.73016595615e-06
ko05164	Influenza A	7/1105	167/7206	6.16122378515e-06
ko04972	Pancreatic secretion	35/1105	111/7206	1.41193022355e-05
ko04745	Phototransduction - fly	17/1105	38/7206	1.47910850634e-05
ko04060	Cytokine-cytokine receptor interaction	10/1105	191/7206	1.56504819502e-05
ko05203	Viral carcinogenesis	19/1105	277/7206	1.82219171011e-05
ko04750	Inflammatory mediator regulation of TRP channels	37/1105	122/7206	2.13574086168e-05
ko03013	RNA transport	8/1105	166/7206	2.75281329347e-05
ko04540	Gap junction	38/1105	128/7206	3.14823928418e-05
ko04010	MAPK signaling pathway	76/1105	321/7206	6.58118466323e-05
ko04621	NOD-like receptor signaling pathway	8/1105	157/7206	7.62914638207e-05
ko04110	Cell cycle	7/1105	145/7206	0.000100711038834
ko04022	cGMP-PKG signaling pathway	55/1105	216/7206	0.000106303715455
ko04514	Cell adhesion molecules (CAMs)	37/1105	130/7206	0.000110504443256
ko04141	Protein processing in endoplasmic reticulum	11/1105	184/7206	0.000110798132152
ko05110	Vibrio cholerae infection	22/1105	63/7206	0.000120272202435
ko04070	Phosphatidylinositol signaling system	33/1105	112/7206	0.00015822950033
ko05162	Measles	5/1105	120/7206	0.000168390492683
ko04120	Ubiquitin mediated proteolysis	7/1105	138/7206	0.0002840269441
ko04072	Phospholipase D signaling pathway	49/1105	197/7206	0.000402468022226
ko03008	Ribosome biogenesis in eukaryotes	2/1105	79/7206	0.000411346700637
ko05169	Epstein-Barr virus infection	15/1105	206/7206	0.000556164663136
ko04612	Antigen processing and presentation	2/1105	77/7206	0.000625250015067
ko04964	Proximal tubule bicarbonate reclamation	12/1105	29/7206	0.000652573125419
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	24/1105	79/7206	0.000732153714863
ko04360	Axon guidance	55/1105	233/7206	0.000804832182049
ko04260	Cardiac muscle contraction	28/1105	98/7206	0.000944633607045
ko05205	Proteoglycans in cancer	23/1105	271/7206	0.00102010972138
ko05161	Hepatitis B	12/1105	173/7206	0.00122360949148
ko04630	Jak-STAT signaling pathway	8/1105	132/7206	0.00142262917234
ko04710	Circadian rhythm	15/1105	43/7206	0.00197411666243
ko00520	Amino sugar and nucleotide sugar metabolism	1/1105	55/7206	0.00209222955135
ko04924	Renin secretion	24/1105	86/7206	0.00236121304046
ko04976	Bile secretion	23/1105	80/7206	0.00250346251022
ko05166	HTLV-I infection	27/1105	292/7206	0.00271051705309
ko04014	Ras signaling pathway	61/1105	279/7206	0.00294682895818
ko04915	Estrogen signaling pathway	33/1105	131/7206	0.00303784062781
ko04626	Plant-pathogen interaction	8/1105	18/7206	0.00309669453752
ko05140	Leishmaniasis	3/1105	75/7206	0.00330363215295
ko05414	Dilated cardiomyopathy	29/1105	112/7206	0.00334330473929
ko04922	Glucagon signaling pathway	32/1105	128/7206	0.00407019521853
ko04330	Notch signaling pathway	2/1105	62/7206	0.00408823460829
ko03420	Nucleotide excision repair	1/1105	46/7206	0.00693817041068
ko04610	Complement and coagulation cascades	4/1105	79/7206	0.00714818790094
ko04146	Peroxisome	5/1105	89/7206	0.00725279574652
ko04960	Aldosterone-regulated sodium reabsorption	13/1105	41/7206	0.00751312467783
ko05145	Toxoplasmosis	9/1105	126/7206	0.00830747183223
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1105	59/7206	0.00951910315394
ko04064	NF-kappa B signaling pathway	6/1105	96/7206	0.00977716014638
ko03022	Basal transcription factors	1/1105	44/7206	0.0104233602495
ko04510	Focal adhesion	23/1105	240/7206	0.0105195206564
ko00071	Fatty acid degradation	1/1105	45/7206	0.0107864582119
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1105	182/7206	0.0119927871463
ko00280	Valine, leucine and isoleucine degradation	2/1105	54/7206	0.0126302979287
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1105	14/7206	0.0127417759871
ko04270	Vascular smooth muscle contraction	35/1105	154/7206	0.0127970035758
ko00310	Lysine degradation	4/1105	73/7206	0.0140031606721
ko04918	Thyroid hormone synthesis	22/1105	86/7206	0.0147439634758
ko04912	GnRH signaling pathway	29/1105	122/7206	0.0151842238318
ko05200	Pathways in cancer	57/1105	492/7206	0.0163481579174
ko04114	Oocyte meiosis	32/1105	139/7206	0.0166976305841
ko00910	Nitrogen metabolism	7/1105	19/7206	0.0181857883122
ko05131	Shigellosis	5/1105	82/7206	0.0194084119971
ko04622	RIG-I-like receptor signaling pathway	3/1105	62/7206	0.0197174982464
ko04214	Apoptosis - fly	4/1105	72/7206	0.0198736070851
ko04930	Type II diabetes mellitus	15/1105	54/7206	0.0204820700939
ko04550	Signaling pathways regulating pluripotency of stem cells	15/1105	165/7206	0.0216197594378
ko00630	Glyoxylate and dicarboxylate metabolism	1/1105	38/7206	0.0229695048666
ko05202	Transcriptional misregulation in cancer	18/1105	188/7206	0.0239672923244
ko04657	IL-17 signaling pathway	6/1105	87/7206	0.0244024677223
ko05133	Pertussis	6/1105	87/7206	0.0244024677223
ko05222	Small cell lung cancer	6/1105	89/7206	0.0249745854192
ko04371	Apelin signaling pathway	38/1105	177/7206	0.0262556301285
ko00230	Purine metabolism	41/1105	194/7206	0.0262753662458
ko05219	Bladder cancer	2/1105	48/7206	0.0262756991393
ko04658	Th1 and Th2 cell differentiation	7/1105	96/7206	0.0309784354064
ko00240	Pyrimidine metabolism	9/1105	110/7206	0.032874145965
ko05220	Chronic myeloid leukemia	6/1105	85/7206	0.0329537027384
ko05206	MicroRNAs in cancer	17/1105	177/7206	0.0339942566351
ko04916	Melanogenesis	31/1105	142/7206	0.0341976172396
ko04115	p53 signaling pathway	5/1105	74/7206	0.0352859580466
ko05410	Hypertrophic cardiomyopathy (HCM)	23/1105	100/7206	0.0363493394583
ko05144	Malaria	2/1105	45/7206	0.037769855912
ko05321	Inflammatory bowel disease (IBD)	3/1105	56/7206	0.0386650235017
ko05418	Fluid shear stress and atherosclerosis	17/1105	173/7206	0.0421121613209
ko04810	Regulation of actin cytoskeleton	29/1105	264/7206	0.0453105772647
ko04210	Apoptosis	18/1105	180/7206	0.0460767180092
ko04620	Toll-like receptor signaling pathway	8/1105	100/7206	0.0487455486184