ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	204/1235	423/7206	5.78645790262e-53
ko04724	Glutamatergic synapse	89/1235	152/7206	3.07919335677e-31
ko05033	Nicotine addiction	48/1235	56/7206	2.71263158457e-29
ko05032	Morphine addiction	68/1235	110/7206	4.77700582785e-26
ko04713	Circadian entrainment	76/1235	136/7206	5.33018132003e-25
ko04727	GABAergic synapse	64/1235	110/7206	1.60947503518e-22
ko04728	Dopaminergic synapse	86/1235	185/7206	5.91350691253e-21
ko04721	Synaptic vesicle cycle	51/1235	80/7206	1.09686190325e-20
ko04024	cAMP signaling pathway	109/1235	279/7206	7.1961893351e-19
ko04020	Calcium signaling pathway	105/1235	265/7206	8.52484928329e-19
ko04725	Cholinergic synapse	74/1235	160/7206	5.10889694471e-18
ko04723	Retrograde endocannabinoid signaling	76/1235	175/7206	1.50423396936e-16
ko04742	Taste transduction	38/1235	61/7206	3.05016199909e-15
ko04911	Insulin secretion	56/1235	117/7206	9.87226188734e-15
ko04726	Serotonergic synapse	61/1235	137/7206	4.06531162181e-14
ko04921	Oxytocin signaling pathway	80/1235	209/7206	1.92258226462e-13
ko04744	Phototransduction	25/1235	36/7206	4.96923940771e-12
ko04261	Adrenergic signaling in cardiomyocytes	74/1235	205/7206	4.36215304105e-11
ko03040	Spliceosome	1/1235	145/7206	7.34622145478e-11
ko05031	Amphetamine addiction	42/1235	91/7206	9.83593765096e-11
ko04970	Salivary secretion	43/1235	95/7206	1.28857603288e-10
ko04720	Long-term potentiation	43/1235	99/7206	6.49162539185e-10
ko05203	Viral carcinogenesis	14/1235	277/7206	9.90471460212e-10
ko04022	cGMP-PKG signaling pathway	72/1235	216/7206	3.90423345353e-09
ko04740	Olfactory transduction	36/1235	80/7206	5.08238012524e-09
ko04360	Axon guidance	75/1235	233/7206	1.3908590852e-08
ko05322	Systemic lupus erythematosus	5/1235	151/7206	1.63012201611e-07
ko04060	Cytokine-cytokine receptor interaction	9/1235	191/7206	2.5679951739e-07
ko05030	Cocaine addiction	31/1235	73/7206	2.98227352522e-07
ko03013	RNA transport	7/1235	166/7206	5.76992647305e-07
ko04925	Aldosterone synthesis and secretion	39/1235	105/7206	6.95491008305e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1235	74/7206	2.36185198633e-06
ko05168	Herpes simplex infection	10/1235	182/7206	3.33689620073e-06
ko04924	Renin secretion	32/1235	86/7206	7.80602341147e-06
ko04621	NOD-like receptor signaling pathway	8/1235	157/7206	8.16068465198e-06
ko04971	Gastric acid secretion	35/1235	98/7206	8.73500384543e-06
ko05164	Influenza A	9/1235	167/7206	9.19355535481e-06
ko04010	MAPK signaling pathway	86/1235	321/7206	9.48479863813e-06
ko04141	Protein processing in endoplasmic reticulum	11/1235	184/7206	9.81708820515e-06
ko04514	Cell adhesion molecules (CAMs)	42/1235	130/7206	1.80914107111e-05
ko04966	Collecting duct acid secretion	14/1235	26/7206	2.18260157911e-05
ko04120	Ubiquitin mediated proteolysis	7/1235	138/7206	3.04062268787e-05
ko04070	Phosphatidylinositol signaling system	37/1235	112/7206	3.68358631672e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1235	79/7206	7.02470514926e-05
ko04612	Antigen processing and presentation	2/1235	77/7206	0.00010696310936
ko03008	Ribosome biogenesis in eukaryotes	2/1235	79/7206	0.000114108472298
ko04014	Ras signaling pathway	73/1235	279/7206	0.000125298357872
ko05140	Leishmaniasis	2/1235	75/7206	0.000159677569949
ko04064	NF-kappa B signaling pathway	4/1235	96/7206	0.000180722810947
ko04972	Pancreatic secretion	35/1235	111/7206	0.00018207970511
ko04260	Cardiac muscle contraction	32/1235	98/7206	0.000198522192486
ko05205	Proteoglycans in cancer	25/1235	271/7206	0.000204996469978
ko04371	Apelin signaling pathway	50/1235	177/7206	0.000238383836724
ko04745	Phototransduction - fly	16/1235	38/7206	0.000254981727518
ko05161	Hepatitis B	13/1235	173/7206	0.000311609824694
ko05169	Epstein-Barr virus infection	17/1235	206/7206	0.000325542080401
ko04540	Gap junction	38/1235	128/7206	0.000349798948448
ko04730	Long-term depression	26/1235	78/7206	0.00041951421343
ko04610	Complement and coagulation cascades	3/1235	79/7206	0.000460476749184
ko04110	Cell cycle	10/1235	145/7206	0.000482863274599
ko05414	Dilated cardiomyopathy	34/1235	112/7206	0.000535492498789
ko05110	Vibrio cholerae infection	22/1235	63/7206	0.000582843131757
ko04976	Bile secretion	26/1235	80/7206	0.00080695116749
ko05162	Measles	8/1235	120/7206	0.00130864078971
ko04146	Peroxisome	5/1235	89/7206	0.00173062748418
ko00330	Arginine and proline metabolism	2/1235	61/7206	0.00173300634249
ko04964	Proximal tubule bicarbonate reclamation	12/1235	29/7206	0.00180113789431
ko04072	Phospholipase D signaling pathway	51/1235	197/7206	0.00201170779376
ko04923	Regulation of lipolysis in adipocytes	24/1235	77/7206	0.00212458418085
ko04657	IL-17 signaling pathway	5/1235	87/7206	0.00243142553843
ko03420	Nucleotide excision repair	1/1235	46/7206	0.00281202663475
ko04750	Inflammatory mediator regulation of TRP channels	34/1235	122/7206	0.00329746606349
ko00480	Glutathione metabolism	2/1235	55/7206	0.00372990676965
ko04710	Circadian rhythm	15/1235	43/7206	0.00407279733422
ko03022	Basal transcription factors	1/1235	44/7206	0.00424575375016
ko00071	Fatty acid degradation	1/1235	45/7206	0.00438407243482
ko00240	Pyrimidine metabolism	8/1235	110/7206	0.00458740830784
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1235	59/7206	0.00464434223774
ko00310	Lysine degradation	4/1235	73/7206	0.00465566429267
ko04217	Necroptosis	17/1235	178/7206	0.00472169248647
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1235	14/7206	0.00478960812332
ko04630	Jak-STAT signaling pathway	11/1235	132/7206	0.00491214440891
ko04622	RIG-I-like receptor signaling pathway	3/1235	62/7206	0.00621975089561
ko04626	Plant-pathogen interaction	8/1235	18/7206	0.00629553334439
ko04922	Glucagon signaling pathway	34/1235	128/7206	0.00629713062063
ko04214	Apoptosis - fly	4/1235	72/7206	0.00673432306341
ko00380	Tryptophan metabolism	2/1235	50/7206	0.00803337430595
ko00590	Arachidonic acid metabolism	2/1235	52/7206	0.00835332105932
ko05145	Toxoplasmosis	11/1235	126/7206	0.00860583057396
ko05133	Pertussis	6/1235	87/7206	0.00921615620559
ko04915	Estrogen signaling pathway	34/1235	131/7206	0.00973052401713
ko04930	Type II diabetes mellitus	17/1235	54/7206	0.00975932925572
ko05215	Prostate cancer	9/1235	111/7206	0.0104425362466
ko05219	Bladder cancer	2/1235	48/7206	0.0117110551035
ko03018	RNA degradation	6/1235	84/7206	0.0125044939011
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1235	182/7206	0.0126960513138
ko04115	p53 signaling pathway	5/1235	74/7206	0.0128991410252
ko04510	Focal adhesion	27/1235	240/7206	0.0143629286717
ko04711	Circadian rhythm - fly	6/1235	13/7206	0.0144133455087
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1235	100/7206	0.0152153247288
ko05144	Malaria	2/1235	45/7206	0.0171022752858
ko05166	HTLV-I infection	35/1235	292/7206	0.0171278086453
ko05131	Shigellosis	6/1235	82/7206	0.0172491160965
ko00280	Valine, leucine and isoleucine degradation	3/1235	54/7206	0.018170136224
ko04640	Hematopoietic cell lineage	4/1235	64/7206	0.0184403052277
ko05321	Inflammatory bowel disease (IBD)	3/1235	56/7206	0.0188103295186
ko04658	Th1 and Th2 cell differentiation	8/1235	96/7206	0.0197359508019
ko05206	MicroRNAs in cancer	19/1235	177/7206	0.0200551497099
ko00562	Inositol phosphate metabolism	24/1235	89/7206	0.0222608038962
ko03320	PPAR signaling pathway	5/1235	69/7206	0.024442225883
ko04330	Notch signaling pathway	4/1235	62/7206	0.0260195448756
ko01524	Platinum drug resistance	6/1235	76/7206	0.0311913057229
ko05418	Fluid shear stress and atherosclerosis	19/1235	173/7206	0.0313991698677
ko04620	Toll-like receptor signaling pathway	9/1235	100/7206	0.0314557192716
ko04015	Rap1 signaling pathway	61/1235	278/7206	0.0346016296001
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1235	40/7206	0.0359029484054
ko05222	Small cell lung cancer	8/1235	89/7206	0.0460783339977