ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 32/294 152/7206 6.1987484454e-15 ko04744 Phototransduction 15/294 36/7206 2.60770029244e-12 ko05033 Nicotine addiction 16/294 56/7206 3.74082704108e-10 ko04723 Retrograde endocannabinoid signaling 27/294 175/7206 1.65488701835e-09 ko04080 Neuroactive ligand-receptor interaction 45/294 423/7206 1.73643572937e-09 ko05032 Morphine addiction 21/294 110/7206 2.30503316526e-09 ko04720 Long-term potentiation 19/294 99/7206 1.25005604667e-08 ko04713 Circadian entrainment 22/294 136/7206 2.36480906345e-08 ko04024 cAMP signaling pathway 33/294 279/7206 2.48514290171e-08 ko04728 Dopaminergic synapse 26/294 185/7206 2.50806444436e-08 ko04727 GABAergic synapse 19/294 110/7206 7.48835121381e-08 ko04020 Calcium signaling pathway 31/294 265/7206 8.80069538976e-08 ko04261 Adrenergic signaling in cardiomyocytes 23/294 205/7206 8.96761249119e-06 ko04740 Olfactory transduction 13/294 80/7206 1.7896655093e-05 ko04911 Insulin secretion 16/294 117/7206 1.89160873591e-05 ko05031 Amphetamine addiction 13/294 91/7206 7.27398937558e-05 ko04725 Cholinergic synapse 18/294 160/7206 8.33734131148e-05 ko04072 Phospholipase D signaling pathway 20/294 197/7206 0.000143719011115 ko04742 Taste transduction 10/294 61/7206 0.000155698540725 ko05203 Viral carcinogenesis 1/294 277/7206 0.000250123807981 ko04721 Synaptic vesicle cycle 11/294 80/7206 0.000366931598415 ko04726 Serotonergic synapse 15/294 137/7206 0.000436767532557 ko05030 Cocaine addiction 10/294 73/7206 0.000696164313669 ko04921 Oxytocin signaling pathway 19/294 209/7206 0.000992369706214 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 10/294 79/7206 0.00130117988166 ko04062 Chemokine signaling pathway 18/294 201/7206 0.00157640491595 ko05414 Dilated cardiomyopathy 12/294 112/7206 0.00194437555818 ko04014 Ras signaling pathway 22/294 279/7206 0.00285094331078 ko05014 Amyotrophic lateral sclerosis (ALS) 9/294 74/7206 0.002974338771 ko05213 Endometrial cancer 8/294 62/7206 0.00346604199481 ko04022 cGMP-PKG signaling pathway 18/294 216/7206 0.00417646118164 ko04012 ErbB signaling pathway 11/294 109/7206 0.00471892619012 ko00512 Mucin type O-glycan biosynthesis 5/294 29/7206 0.00579370954476 ko04070 Phosphatidylinositol signaling system 11/294 112/7206 0.00579484328476 ko04141 Protein processing in endoplasmic reticulum 1/294 184/7206 0.00719546684945 ko04360 Axon guidance 18/294 233/7206 0.010021072788 ko00562 Inositol phosphate metabolism 9/294 89/7206 0.0100615320828 ko04925 Aldosterone synthesis and secretion 10/294 105/7206 0.0102938353449 ko04144 Endocytosis 24/294 342/7206 0.0106902444058 ko05231 Choline metabolism in cancer 12/294 134/7206 0.0119480759689 ko04923 Regulation of lipolysis in adipocytes 8/294 77/7206 0.0127629504623 ko03013 RNA transport 1/294 166/7206 0.015251794257 ko04260 Cardiac muscle contraction 9/294 98/7206 0.0181515411151 ko04371 Apelin signaling pathway 14/294 177/7206 0.0181746977912 ko04010 MAPK signaling pathway 22/294 321/7206 0.019444876815 ko05410 Hypertrophic cardiomyopathy (HCM) 9/294 100/7206 0.0204553859186 ko04915 Estrogen signaling pathway 11/294 131/7206 0.0218134619594 ko00601 Glycosphingolipid biosynthesis - lacto and neolacto series 4/294 28/7206 0.0256685604761 ko04110 Cell cycle 1/294 145/7206 0.0314568050004 ko04666 Fc gamma R-mediated phagocytosis 10/294 122/7206 0.0328840649745 ko04320 Dorso-ventral axis formation 4/294 31/7206 0.0358810369572 ko04730 Long-term depression 7/294 78/7206 0.0391900617097 ko05214 Glioma 7/294 79/7206 0.0415652251389 ko04972 Pancreatic secretion 9/294 111/7206 0.0464650544534 ko05169 Epstein-Barr virus infection 3/294 206/7206 0.0490786889374 ko05161 Hepatitis B 2/294 173/7206 0.0492096718588