ko pathway ratio_in_study ratio_in_pop p_value ko05217 Basal cell carcinoma 30/575 68/7206 5.52654043497e-16 ko04550 Signaling pathways regulating pluripotency of stem cells 39/575 165/7206 3.42638064762e-10 ko03050 Proteasome 20/575 54/7206 1.93143179689e-09 ko03008 Ribosome biogenesis in eukaryotes 24/575 79/7206 4.79742567259e-09 ko04080 Neuroactive ligand-receptor interaction 7/575 423/7206 9.2120973534e-09 ko04921 Oxytocin signaling pathway 1/575 209/7206 7.86650034426e-07 ko04950 Maturity onset diabetes of the young 12/575 29/7206 8.7231580159e-07 ko04390 Hippo signaling pathway 35/575 188/7206 1.66447064335e-06 ko04310 Wnt signaling pathway 33/575 181/7206 5.15635744573e-06 ko05224 Breast cancer 32/575 174/7206 6.09990711386e-06 ko04723 Retrograde endocannabinoid signaling 1/575 175/7206 1.30101747481e-05 ko05010 Alzheimer's disease 2/575 202/7206 1.54732515384e-05 ko03030 DNA replication 12/575 38/7206 2.33077126596e-05 ko04020 Calcium signaling pathway 5/575 265/7206 2.43414332437e-05 ko04340 Hedgehog signaling pathway 15/575 58/7206 3.31551885178e-05 ko05205 Proteoglycans in cancer 41/575 271/7206 5.14073417994e-05 ko03013 RNA transport 29/575 166/7206 5.5837885207e-05 ko05012 Parkinson's disease 1/575 155/7206 6.28604363277e-05 ko04932 Non-alcoholic fatty liver disease (NAFLD) 2/575 182/7206 7.08831544493e-05 ko04144 Endocytosis 10/575 342/7206 0.000130767866524 ko04072 Phospholipase D signaling pathway 3/575 197/7206 0.000139901800577 ko05200 Pathways in cancer 62/575 492/7206 0.000264937713492 ko04512 ECM-receptor interaction 16/575 79/7206 0.000412439970761 ko04621 NOD-like receptor signaling pathway 2/575 157/7206 0.000461672910434 ko04062 Chemokine signaling pathway 4/575 201/7206 0.00048507221585 ko00970 Aminoacyl-tRNA biosynthesis 11/575 44/7206 0.000510288000901 ko00670 One carbon pool by folate 7/575 20/7206 0.000613041646541 ko04022 cGMP-PKG signaling pathway 5/575 216/7206 0.00076647412158 ko05168 Herpes simplex infection 4/575 182/7206 0.00131458734734 ko04975 Fat digestion and absorption 9/575 35/7206 0.00131921474249 ko04110 Cell cycle 23/575 145/7206 0.00154984458275 ko04725 Cholinergic synapse 3/575 160/7206 0.00165050717793 ko04371 Apelin signaling pathway 4/575 177/7206 0.00183851016421 ko04713 Circadian entrainment 2/575 136/7206 0.00196729783343 ko04726 Serotonergic synapse 2/575 137/7206 0.00201208343039 ko04270 Vascular smooth muscle contraction 3/575 154/7206 0.00231570762253 ko04630 Jak-STAT signaling pathway 2/575 132/7206 0.00289447086367 ko00260 Glycine, serine and threonine metabolism 10/575 48/7206 0.00394558105819 ko05166 HTLV-I infection 37/575 292/7206 0.00405120250612 ko04612 Antigen processing and presentation 14/575 77/7206 0.00435206861752 ko04360 Axon guidance 31/575 233/7206 0.00435882967768 ko04971 Gastric acid secretion 1/575 98/7206 0.00436120936101 ko04350 TGF-beta signaling pathway 17/575 103/7206 0.00480682974384 ko04071 Sphingolipid signaling pathway 4/575 162/7206 0.00495836607659 ko04611 Platelet activation 4/575 163/7206 0.0049824796424 ko05202 Transcriptional misregulation in cancer 26/575 188/7206 0.00574433280644 ko04970 Salivary secretion 1/575 95/7206 0.00648447256389 ko04217 Necroptosis 5/575 178/7206 0.00711697939211 ko00514 Other types of O-glycan biosynthesis 7/575 30/7206 0.00799602239617 ko04070 Phosphatidylinositol signaling system 2/575 112/7206 0.0080448127568 ko00460 Cyanoamino acid metabolism 4/575 11/7206 0.00840883768669 ko04728 Dopaminergic synapse 6/575 185/7206 0.0126560409155 ko05016 Huntington's disease 8/575 215/7206 0.0149467834959 ko05222 Small cell lung cancer 14/575 89/7206 0.015477207428 ko04925 Aldosterone synthesis and secretion 2/575 105/7206 0.0165791687471 ko04666 Fc gamma R-mediated phagocytosis 3/575 122/7206 0.0175074673393 ko04722 Neurotrophin signaling pathway 5/575 160/7206 0.0175512966633 ko05169 Epstein-Barr virus infection 26/575 206/7206 0.0180956903116 ko00240 Pyrimidine metabolism 16/575 110/7206 0.0189822772428 ko04721 Synaptic vesicle cycle 1/575 80/7206 0.0201033131055 ko04138 Autophagy - yeast 1/575 81/7206 0.0204890955957 ko04137 Mitophagy - animal 1/575 82/7206 0.0210117819975 ko04974 Protein digestion and absorption 14/575 96/7206 0.0224712600252 ko05132 Salmonella infection 2/575 98/7206 0.0230324953369 ko05160 Hepatitis C 5/575 153/7206 0.0236399272328 ko03410 Base excision repair 7/575 38/7206 0.028535059543 ko04330 Notch signaling pathway 10/575 62/7206 0.0294239418082 ko04111 Cell cycle - yeast 13/575 90/7206 0.0303127170234 ko04915 Estrogen signaling pathway 4/575 131/7206 0.033159803509 ko04972 Pancreatic secretion 3/575 111/7206 0.0335043371329 ko04064 NF-kappa B signaling pathway 2/575 96/7206 0.03384069591 ko05231 Choline metabolism in cancer 4/575 134/7206 0.0341887338804 ko04024 cAMP signaling pathway 13/575 279/7206 0.0414317441249 ko04916 Melanogenesis 18/575 142/7206 0.0421461636683 ko04660 T cell receptor signaling pathway 4/575 124/7206 0.0447232555191 ko05133 Pertussis 2/575 87/7206 0.0455881629697 ko04924 Renin secretion 2/575 86/7206 0.0455996205183 ko04662 B cell receptor signaling pathway 2/575 88/7206 0.0457918040411 ko04540 Gap junction 4/575 128/7206 0.0457970355219 ko00562 Inositol phosphate metabolism 2/575 89/7206 0.0462094908481 ko05031 Amphetamine addiction 2/575 91/7206 0.0476837130416