ko pathway ratio_in_study ratio_in_pop p_value ko05164 Influenza A 34/213 167/7206 8.5934718099e-20 ko04060 Cytokine-cytokine receptor interaction 33/213 191/7206 6.04928567787e-17 ko05168 Herpes simplex infection 32/213 182/7206 1.10449451333e-16 ko05340 Primary immunodeficiency 15/213 30/7206 7.37488572507e-16 ko04621 NOD-like receptor signaling pathway 29/213 157/7206 8.69141038199e-16 ko04064 NF-kappa B signaling pathway 22/213 96/7206 2.99931523935e-14 ko05162 Measles 24/213 120/7206 4.93556960642e-14 ko05152 Tuberculosis 27/213 187/7206 4.53241744078e-12 ko04380 Osteoclast differentiation 23/213 134/7206 5.04829866759e-12 ko04612 Antigen processing and presentation 18/213 77/7206 5.08185531235e-12 ko04620 Toll-like receptor signaling pathway 20/213 100/7206 7.10845154308e-12 ko05145 Toxoplasmosis 22/213 126/7206 1.05818615191e-11 ko05140 Leishmaniasis 17/213 75/7206 3.46358098569e-11 ko05321 Inflammatory bowel disease (IBD) 15/213 56/7206 3.91335699292e-11 ko04650 Natural killer cell mediated cytotoxicity 18/213 97/7206 3.0951041948e-10 ko04217 Necroptosis 24/213 178/7206 3.29350371365e-10 ko05133 Pertussis 17/213 87/7206 4.21875228526e-10 ko05332 Graft-versus-host disease 9/213 18/7206 5.62091703592e-10 ko05330 Allograft rejection 10/213 24/7206 5.63755553117e-10 ko05161 Hepatitis B 23/213 173/7206 1.04904827855e-09 ko04659 Th17 cell differentiation 18/213 106/7206 1.40593201053e-09 ko05320 Autoimmune thyroid disease 10/213 29/7206 5.05723878195e-09 ko04940 Type I diabetes mellitus 10/213 32/7206 1.50693598357e-08 ko04658 Th1 and Th2 cell differentiation 16/213 96/7206 1.5832442134e-08 ko04660 T cell receptor signaling pathway 18/213 124/7206 1.86663624846e-08 ko04622 RIG-I-like receptor signaling pathway 13/213 62/7206 2.11069020694e-08 ko04630 Jak-STAT signaling pathway 18/213 132/7206 5.06588724602e-08 ko04668 TNF signaling pathway 17/213 120/7206 6.82781853839e-08 ko05167 Kaposi's sarcoma-associated herpesvirus infection 21/213 191/7206 1.71008816853e-07 ko05323 Rheumatoid arthritis 14/213 89/7206 2.72832646783e-07 ko04640 Hematopoietic cell lineage 12/213 64/7206 2.76752600537e-07 ko04062 Chemokine signaling pathway 21/213 201/7206 4.07827929549e-07 ko05144 Malaria 10/213 45/7206 5.32143231103e-07 ko05150 Staphylococcus aureus infection 9/213 36/7206 6.8439140115e-07 ko05142 Chagas disease (American trypanosomiasis) 16/213 130/7206 1.19256443791e-06 ko04623 Cytosolic DNA-sensing pathway 9/213 41/7206 2.23950309456e-06 ko05160 Hepatitis C 17/213 153/7206 2.33517655709e-06 ko05310 Asthma 6/213 17/7206 5.85862725155e-06 ko04662 B cell receptor signaling pathway 12/213 88/7206 9.26237991328e-06 ko04672 Intestinal immune network for IgA production 8/213 37/7206 9.42133954499e-06 ko05134 Legionellosis 11/213 74/7206 9.46797041841e-06 ko04210 Apoptosis 17/213 180/7206 2.10413133771e-05 ko04145 Phagosome 16/213 162/7206 2.12359593659e-05 ko04657 IL-17 signaling pathway 11/213 87/7206 4.52907894143e-05 ko05132 Salmonella infection 11/213 98/7206 0.000136311028164 ko05131 Shigellosis 10/213 82/7206 0.000137306334893 ko05416 Viral myocarditis 8/213 55/7206 0.000188032694672 ko04514 Cell adhesion molecules (CAMs) 12/213 130/7206 0.000436694816589 ko05166 HTLV-I infection 20/213 292/7206 0.000504766698505 ko03050 Proteasome 7/213 54/7206 0.00097109221453 ko05143 African trypanosomiasis 5/213 32/7206 0.00226009365032 ko05146 Amoebiasis 9/213 99/7206 0.00251333024256 ko04080 Neuroactive ligand-receptor interaction 3/213 423/7206 0.00259950618098 ko04666 Fc gamma R-mediated phagocytosis 10/213 122/7206 0.00317217606432 ko05169 Epstein-Barr virus infection 14/213 206/7206 0.00494730080352 ko04670 Leukocyte transendothelial migration 11/213 151/7206 0.00498896305849 ko04664 Fc epsilon RI signaling pathway 7/213 77/7206 0.00744788797487 ko04610 Complement and coagulation cascades 7/213 79/7206 0.00854498932464 ko05034 Alcoholism 1/213 238/7206 0.010454921371 ko05120 Epithelial cell signaling in Helicobacter pylori infection 7/213 92/7206 0.018754215628 ko05016 Huntington's disease 1/213 215/7206 0.0221666781076 ko01524 Platinum drug resistance 6/213 76/7206 0.0244260244558 ko04020 Calcium signaling pathway 2/213 265/7206 0.0251077832388 ko04310 Wnt signaling pathway 1/213 181/7206 0.0453178741172 ko04728 Dopaminergic synapse 1/213 185/7206 0.0454701533329 ko04390 Hippo signaling pathway 1/213 188/7206 0.0459604346248