ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 141/790 423/7206 1.10407355126e-37 ko04724 Glutamatergic synapse 76/790 152/7206 5.05511450689e-34 ko05033 Nicotine addiction 43/790 56/7206 8.61681858616e-31 ko04727 GABAergic synapse 54/790 110/7206 6.69472753544e-24 ko05032 Morphine addiction 54/790 110/7206 6.69472753544e-24 ko04728 Dopaminergic synapse 72/790 185/7206 7.83793697459e-24 ko04713 Circadian entrainment 59/790 136/7206 1.5656862571e-22 ko04723 Retrograde endocannabinoid signaling 66/790 175/7206 4.95041223775e-21 ko04721 Synaptic vesicle cycle 41/790 80/7206 2.64985352995e-19 ko04725 Cholinergic synapse 56/790 160/7206 2.7776754591e-16 ko04024 cAMP signaling pathway 78/790 279/7206 8.61622609465e-16 ko04911 Insulin secretion 43/790 117/7206 1.26011080258e-13 ko05031 Amphetamine addiction 35/790 91/7206 5.4631765458e-12 ko04921 Oxytocin signaling pathway 58/790 209/7206 7.3701992763e-12 ko04020 Calcium signaling pathway 67/790 265/7206 1.82411182606e-11 ko04720 Long-term potentiation 36/790 99/7206 1.85793389058e-11 ko04742 Taste transduction 27/790 61/7206 3.2112158009e-11 ko04261 Adrenergic signaling in cardiomyocytes 56/790 205/7206 3.4157224061e-11 ko04744 Phototransduction 20/790 36/7206 6.62891620819e-11 ko04726 Serotonergic synapse 42/790 137/7206 2.15736922613e-10 ko04970 Salivary secretion 30/790 95/7206 4.0202990971e-08 ko05030 Cocaine addiction 25/790 73/7206 9.24932413229e-08 ko04925 Aldosterone synthesis and secretion 30/790 105/7206 4.75349739395e-07 ko05203 Viral carcinogenesis 8/790 277/7206 6.5910437463e-07 ko03040 Spliceosome 1/790 145/7206 1.30825285671e-06 ko04060 Cytokine-cytokine receptor interaction 4/790 191/7206 5.33576808312e-06 ko04010 MAPK signaling pathway 62/790 321/7206 5.94298950084e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 22/790 74/7206 7.91383724265e-06 ko05164 Influenza A 3/790 167/7206 8.18117338506e-06 ko05168 Herpes simplex infection 4/790 182/7206 1.104228286e-05 ko04514 Cell adhesion molecules (CAMs) 32/790 130/7206 1.1197707287e-05 ko04971 Gastric acid secretion 26/790 98/7206 1.21972021423e-05 ko04745 Phototransduction - fly 14/790 38/7206 2.50587588802e-05 ko04740 Olfactory transduction 22/790 80/7206 3.09313753884e-05 ko04260 Cardiac muscle contraction 25/790 98/7206 4.74336659009e-05 ko04972 Pancreatic secretion 27/790 111/7206 4.77223818168e-05 ko04730 Long-term depression 21/790 78/7206 6.56231207988e-05 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 21/790 79/7206 8.03479891695e-05 ko04022 cGMP-PKG signaling pathway 43/790 216/7206 8.74711603843e-05 ko04072 Phospholipase D signaling pathway 40/790 197/7206 0.000105920586145 ko04120 Ubiquitin mediated proteolysis 3/790 138/7206 0.000161388430126 ko04966 Collecting duct acid secretion 10/790 26/7206 0.000243476954145 ko04621 NOD-like receptor signaling pathway 5/790 157/7206 0.000652674108973 ko05322 Systemic lupus erythematosus 5/790 151/7206 0.000889286104624 ko03013 RNA transport 6/790 166/7206 0.000947433613044 ko05169 Epstein-Barr virus infection 9/790 206/7206 0.000957066776873 ko05162 Measles 3/790 120/7206 0.000995110740906 ko04070 Phosphatidylinositol signaling system 24/790 112/7206 0.00111593119099 ko04360 Axon guidance 42/790 233/7206 0.00124330171211 ko04924 Renin secretion 20/790 86/7206 0.00130576505691 ko04140 Autophagy - animal 6/790 164/7206 0.00135551791484 ko03008 Ribosome biogenesis in eukaryotes 1/790 79/7206 0.00175793001413 ko04141 Protein processing in endoplasmic reticulum 8/790 184/7206 0.00178842219274 ko04626 Plant-pathogen interaction 7/790 18/7206 0.00198765067321 ko05215 Prostate cancer 3/790 111/7206 0.00201493514945 ko05205 Proteoglycans in cancer 15/790 271/7206 0.00206812955181 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/790 14/7206 0.00235511420281 ko04612 Antigen processing and presentation 1/790 77/7206 0.00266585718893 ko05166 HTLV-I infection 17/790 292/7206 0.00288628735265 ko04510 Focal adhesion 13/790 240/7206 0.00317698708454 ko05414 Dilated cardiomyopathy 23/790 112/7206 0.0031797253045 ko05110 Vibrio cholerae infection 15/790 63/7206 0.00337377523941 ko04540 Gap junction 25/790 128/7206 0.00381839476562 ko05161 Hepatitis B 8/790 173/7206 0.00437276479687 ko04110 Cell cycle 6/790 145/7206 0.00460493627911 ko04915 Estrogen signaling pathway 25/790 131/7206 0.00658816393722 ko04014 Ras signaling pathway 45/790 279/7206 0.00796232913587 ko04750 Inflammatory mediator regulation of TRP channels 23/790 122/7206 0.00807230252721 ko04064 NF-kappa B signaling pathway 3/790 96/7206 0.0081033476613 ko04640 Hematopoietic cell lineage 1/790 64/7206 0.0083390043526 ko04964 Proximal tubule bicarbonate reclamation 8/790 29/7206 0.0106057265834 ko00330 Arginine and proline metabolism 1/790 61/7206 0.0122940306616 ko05410 Hypertrophic cardiomyopathy (HCM) 19/790 100/7206 0.0147459103399 ko05140 Leishmaniasis 2/790 75/7206 0.0147862862173 ko04630 Jak-STAT signaling pathway 6/790 132/7206 0.0157856944499 ko04350 TGF-beta signaling pathway 4/790 103/7206 0.0163492188386 ko05010 Alzheimer's disease 33/790 202/7206 0.0163972133712 ko04214 Apoptosis - fly 2/790 72/7206 0.0212525313469 ko00310 Lysine degradation 2/790 73/7206 0.021648553689 ko03018 RNA degradation 3/790 84/7206 0.022345881224 ko04670 Leukocyte transendothelial migration 8/790 151/7206 0.0241694055071 ko05034 Alcoholism 37/790 238/7206 0.0263089726951 ko00480 Glutathione metabolism 1/790 55/7206 0.027131528426 ko00240 Pyrimidine metabolism 5/790 110/7206 0.0298189220071 ko04932 Non-alcoholic fatty liver disease (NAFLD) 11/790 182/7206 0.0299847237386 ko05217 Basal cell carcinoma 2/790 68/7206 0.0301511002372 ko04961 Endocrine and other factor-regulated calcium reabsorption 12/790 59/7206 0.0328608910888 ko00512 Mucin type O-glycan biosynthesis 7/790 29/7206 0.0335505614024 ko04912 GnRH signaling pathway 21/790 122/7206 0.0388547241551 ko00562 Inositol phosphate metabolism 16/790 89/7206 0.0399450448101 ko00513 Various types of N-glycan biosynthesis 9/790 42/7206 0.0427760487086 ko04973 Carbohydrate digestion and absorption 9/790 42/7206 0.0427760487086 ko04550 Signaling pathways regulating pluripotency of stem cells 10/790 165/7206 0.0428134361924 ko04930 Type II diabetes mellitus 11/790 54/7206 0.0442195196649 ko04810 Regulation of actin cytoskeleton 19/790 264/7206 0.0446833480018 ko04371 Apelin signaling pathway 28/790 177/7206 0.04991913352