ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	204/1198	423/7206	2.55954864014e-55
ko04724	Glutamatergic synapse	94/1198	152/7206	7.64043821165e-37
ko05033	Nicotine addiction	50/1198	56/7206	5.33683556159e-33
ko05032	Morphine addiction	71/1198	110/7206	9.84550294636e-30
ko04727	GABAergic synapse	70/1198	110/7206	9.29079024177e-29
ko04713	Circadian entrainment	79/1198	136/7206	2.01510962493e-28
ko04725	Cholinergic synapse	80/1198	160/7206	5.86029956392e-23
ko04728	Dopaminergic synapse	86/1198	185/7206	7.19865425633e-22
ko04721	Synaptic vesicle cycle	51/1198	80/7206	2.68033114825e-21
ko04723	Retrograde endocannabinoid signaling	82/1198	175/7206	3.58079740665e-21
ko04024	cAMP signaling pathway	106/1198	279/7206	2.83346994666e-18
ko04020	Calcium signaling pathway	101/1198	265/7206	9.99448580701e-18
ko04911	Insulin secretion	58/1198	117/7206	1.00122987423e-16
ko04742	Taste transduction	37/1198	61/7206	8.91331091761e-15
ko04726	Serotonergic synapse	61/1198	137/7206	9.61138958209e-15
ko04744	Phototransduction	27/1198	36/7206	1.44145452452e-14
ko04921	Oxytocin signaling pathway	79/1198	209/7206	8.62921891248e-14
ko05031	Amphetamine addiction	45/1198	91/7206	3.28273984435e-13
ko04720	Long-term potentiation	46/1198	99/7206	3.07452574118e-12
ko04261	Adrenergic signaling in cardiomyocytes	72/1198	205/7206	5.99338819069e-11
ko03040	Spliceosome	1/1198	145/7206	1.19082037734e-10
ko04970	Salivary secretion	42/1198	95/7206	1.96797874358e-10
ko04925	Aldosterone synthesis and secretion	44/1198	105/7206	6.05165192259e-10
ko04740	Olfactory transduction	36/1198	80/7206	2.17338914882e-09
ko05030	Cocaine addiction	32/1198	73/7206	3.70829136362e-08
ko04971	Gastric acid secretion	38/1198	98/7206	1.25731217745e-07
ko04360	Axon guidance	70/1198	233/7206	2.28134573061e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1198	74/7206	7.8290414253e-07
ko03013	RNA transport	7/1198	166/7206	1.29324285107e-06
ko05322	Systemic lupus erythematosus	6/1198	151/7206	2.21821653281e-06
ko05168	Herpes simplex infection	9/1198	182/7206	2.3796773429e-06
ko04022	cGMP-PKG signaling pathway	63/1198	216/7206	2.73910073415e-06
ko04621	NOD-like receptor signaling pathway	7/1198	157/7206	3.73002416264e-06
ko04060	Cytokine-cytokine receptor interaction	11/1198	191/7206	7.30461137449e-06
ko04730	Long-term depression	29/1198	78/7206	9.91300611273e-06
ko04010	MAPK signaling pathway	84/1198	321/7206	1.04435384134e-05
ko05203	Viral carcinogenesis	21/1198	277/7206	1.0800052801e-05
ko04120	Ubiquitin mediated proteolysis	6/1198	138/7206	1.38450508013e-05
ko04072	Phospholipase D signaling pathway	57/1198	197/7206	1.51149808543e-05
ko04070	Phosphatidylinositol signaling system	37/1198	112/7206	1.65946035312e-05
ko04540	Gap junction	41/1198	128/7206	1.84909454255e-05
ko04141	Protein processing in endoplasmic reticulum	11/1198	184/7206	1.98983000371e-05
ko04514	Cell adhesion molecules (CAMs)	41/1198	130/7206	2.26562724379e-05
ko04750	Inflammatory mediator regulation of TRP channels	39/1198	122/7206	2.2976530206e-05
ko04014	Ras signaling pathway	73/1198	279/7206	3.64885364412e-05
ko04972	Pancreatic secretion	36/1198	111/7206	4.63836608516e-05
ko05164	Influenza A	10/1198	167/7206	5.2332526178e-05
ko04110	Cell cycle	8/1198	145/7206	6.8278421592e-05
ko04966	Collecting duct acid secretion	13/1198	26/7206	8.53681505848e-05
ko05414	Dilated cardiomyopathy	35/1198	112/7206	0.00010239701825
ko03008	Ribosome biogenesis in eukaryotes	2/1198	79/7206	0.000112341434206
ko04612	Antigen processing and presentation	2/1198	77/7206	0.000166496067581
ko04745	Phototransduction - fly	16/1198	38/7206	0.000176907594668
ko04915	Estrogen signaling pathway	38/1198	131/7206	0.000329846452118
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1198	59/7206	0.00033726166444
ko04924	Renin secretion	28/1198	86/7206	0.000348547299479
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1198	79/7206	0.000351925686211
ko05110	Vibrio cholerae infection	22/1198	63/7206	0.00045096751214
ko05169	Epstein-Barr virus infection	17/1198	206/7206	0.00058163945152
ko04260	Cardiac muscle contraction	29/1198	98/7206	0.00141520151151
ko04923	Regulation of lipolysis in adipocytes	24/1198	77/7206	0.00169127474827
ko05162	Measles	8/1198	120/7206	0.00181294284563
ko00240	Pyrimidine metabolism	7/1198	110/7206	0.00184111800891
ko04912	GnRH signaling pathway	33/1198	122/7206	0.00307865743733
ko04610	Complement and coagulation cascades	4/1198	79/7206	0.0034121050443
ko04064	NF-kappa B signaling pathway	6/1198	96/7206	0.00353899943676
ko04976	Bile secretion	24/1198	80/7206	0.00353971726979
ko04146	Peroxisome	5/1198	89/7206	0.00365302749576
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1198	14/7206	0.00401147267047
ko00071	Fatty acid degradation	1/1198	45/7206	0.00435183989215
ko03420	Nucleotide excision repair	1/1198	46/7206	0.00442858410596
ko04626	Plant-pathogen interaction	8/1198	18/7206	0.00519735704345
ko04973	Carbohydrate digestion and absorption	14/1198	42/7206	0.00653629325705
ko00310	Lysine degradation	4/1198	73/7206	0.00674789865978
ko03022	Basal transcription factors	1/1198	44/7206	0.00680288971603
ko05131	Shigellosis	5/1198	82/7206	0.00684376226926
ko04922	Glucagon signaling pathway	33/1198	128/7206	0.0079528565108
ko04918	Thyroid hormone synthesis	24/1198	86/7206	0.00804602023936
ko00590	Arachidonic acid metabolism	2/1198	52/7206	0.00820052617964
ko04916	Melanogenesis	36/1198	142/7206	0.00833758710988
ko04015	Rap1 signaling pathway	63/1198	278/7206	0.00833782566163
ko04930	Type II diabetes mellitus	17/1198	54/7206	0.00874001416571
ko00330	Arginine and proline metabolism	3/1198	61/7206	0.00911782827596
ko04330	Notch signaling pathway	3/1198	62/7206	0.00920828476896
ko04622	RIG-I-like receptor signaling pathway	3/1198	62/7206	0.00920828476896
ko05231	Choline metabolism in cancer	34/1198	134/7206	0.00947363113643
ko04214	Apoptosis - fly	4/1198	72/7206	0.00982883619074
ko04710	Circadian rhythm	14/1198	43/7206	0.0114283942382
ko04658	Th1 and Th2 cell differentiation	7/1198	96/7206	0.0121765306367
ko05205	Proteoglycans in cancer	30/1198	271/7206	0.0123072471762
ko04657	IL-17 signaling pathway	6/1198	87/7206	0.0128637420476
ko05133	Pertussis	6/1198	87/7206	0.0128637420476
ko04371	Apelin signaling pathway	42/1198	177/7206	0.0137816618298
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1198	100/7206	0.0147195355907
ko05145	Toxoplasmosis	11/1198	126/7206	0.0151781995047
ko03018	RNA degradation	6/1198	84/7206	0.01739311563
ko05219	Bladder cancer	2/1198	48/7206	0.0177202677044
ko04630	Jak-STAT signaling pathway	12/1198	132/7206	0.0177488004985
ko04960	Aldosterone-regulated sodium reabsorption	13/1198	41/7206	0.0178961330623
ko05140	Leishmaniasis	5/1198	75/7206	0.0182725917692
ko05321	Inflammatory bowel disease (IBD)	3/1198	56/7206	0.0184961822273
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1198	182/7206	0.0204125158034
ko04062	Chemokine signaling pathway	46/1198	201/7206	0.0206409461892
ko00500	Starch and sucrose metabolism	1/1198	35/7206	0.021980323036
ko05214	Glioma	21/1198	79/7206	0.0221084824863
ko05144	Malaria	2/1198	45/7206	0.0253750616267
ko00280	Valine, leucine and isoleucine degradation	3/1198	54/7206	0.0263136546705
ko00910	Nitrogen metabolism	7/1198	19/7206	0.0275498582889
ko04270	Vascular smooth muscle contraction	36/1198	154/7206	0.0281980511193
ko04114	Oocyte meiosis	33/1198	139/7206	0.0283358255946
ko04213	Longevity regulating pathway - multiple species	22/1198	86/7206	0.0290592472852
ko05161	Hepatitis B	18/1198	173/7206	0.0292485823654
ko00562	Inositol phosphate metabolism	23/1198	89/7206	0.030154125936
ko03320	PPAR signaling pathway	5/1198	69/7206	0.0339540809625
ko00983	Drug metabolism - other enzymes	2/1198	42/7206	0.0364146727042
ko04210	Apoptosis	20/1198	180/7206	0.0427106611101
ko04964	Proximal tubule bicarbonate reclamation	9/1198	29/7206	0.0454776523461