ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	177/1039	423/7206	3.08364037433e-46
ko04724	Glutamatergic synapse	89/1039	152/7206	2.56875944098e-37
ko05033	Nicotine addiction	50/1039	56/7206	4.28230387432e-36
ko04727	GABAergic synapse	68/1039	110/7206	9.95697771174e-31
ko05032	Morphine addiction	68/1039	110/7206	9.95697771174e-31
ko04713	Circadian entrainment	72/1039	136/7206	1.48840618367e-26
ko04728	Dopaminergic synapse	85/1039	185/7206	1.50858416877e-25
ko04723	Retrograde endocannabinoid signaling	79/1039	175/7206	3.44913553046e-23
ko04725	Cholinergic synapse	73/1039	160/7206	7.75327481745e-22
ko04721	Synaptic vesicle cycle	46/1039	80/7206	2.63930166783e-19
ko04726	Serotonergic synapse	61/1039	137/7206	8.95185115945e-18
ko04020	Calcium signaling pathway	91/1039	265/7206	1.03064817663e-16
ko04744	Phototransduction	27/1039	36/7206	3.68955303739e-16
ko04024	cAMP signaling pathway	93/1039	279/7206	3.78874673071e-16
ko04720	Long-term potentiation	47/1039	99/7206	2.68038377899e-15
ko04911	Insulin secretion	52/1039	117/7206	2.75465703906e-15
ko04921	Oxytocin signaling pathway	75/1039	209/7206	3.2399531942e-15
ko04742	Taste transduction	34/1039	61/7206	4.81686711693e-14
ko05031	Amphetamine addiction	43/1039	91/7206	5.16757572972e-14
ko04261	Adrenergic signaling in cardiomyocytes	66/1039	205/7206	5.08221708271e-11
ko04740	Olfactory transduction	35/1039	80/7206	1.77834325669e-10
ko04970	Salivary secretion	37/1039	95/7206	2.86568114469e-09
ko04925	Aldosterone synthesis and secretion	39/1039	105/7206	5.29182359007e-09
ko05030	Cocaine addiction	30/1039	73/7206	2.12705222445e-08
ko04971	Gastric acid secretion	36/1039	98/7206	2.88187797452e-08
ko04060	Cytokine-cytokine receptor interaction	5/1039	191/7206	5.15962716781e-08
ko03040	Spliceosome	2/1039	145/7206	6.47150398489e-08
ko04070	Phosphatidylinositol signaling system	38/1039	112/7206	1.60960762174e-07
ko04730	Long-term depression	29/1039	78/7206	4.78112454944e-07
ko05203	Viral carcinogenesis	14/1039	277/7206	7.38463682753e-07
ko04745	Phototransduction - fly	18/1039	38/7206	1.20396249453e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1039	74/7206	1.8176898323e-06
ko04010	MAPK signaling pathway	78/1039	321/7206	1.87484831366e-06
ko04072	Phospholipase D signaling pathway	52/1039	197/7206	7.42287461187e-06
ko05322	Systemic lupus erythematosus	5/1039	151/7206	1.01421967863e-05
ko04141	Protein processing in endoplasmic reticulum	8/1039	184/7206	1.55808293578e-05
ko04966	Collecting duct acid secretion	13/1039	26/7206	1.80509562569e-05
ko04110	Cell cycle	5/1039	145/7206	2.09992346119e-05
ko03013	RNA transport	7/1039	166/7206	2.75326740446e-05
ko05164	Influenza A	7/1039	167/7206	2.79607108246e-05
ko04022	cGMP-PKG signaling pathway	54/1039	216/7206	2.95118279743e-05
ko04540	Gap junction	36/1039	128/7206	5.80104328237e-05
ko05168	Herpes simplex infection	9/1039	182/7206	6.19627264953e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/1039	79/7206	7.59331389978e-05
ko04621	NOD-like receptor signaling pathway	7/1039	157/7206	7.71680784563e-05
ko04972	Pancreatic secretion	32/1039	111/7206	9.47046397165e-05
ko05162	Measles	4/1039	120/7206	0.000108704476566
ko04260	Cardiac muscle contraction	29/1039	98/7206	0.00011063510499
ko05169	Epstein-Barr virus infection	12/1039	206/7206	0.000116921599709
ko04612	Antigen processing and presentation	1/1039	77/7206	0.000126404887764
ko04360	Axon guidance	55/1039	233/7206	0.000134089673452
ko05110	Vibrio cholerae infection	21/1039	63/7206	0.000169303626544
ko04514	Cell adhesion molecules (CAMs)	35/1039	130/7206	0.00019898748024
ko04750	Inflammatory mediator regulation of TRP channels	33/1039	122/7206	0.000221627445058
ko04924	Renin secretion	25/1039	86/7206	0.000493577572963
ko04915	Estrogen signaling pathway	34/1039	131/7206	0.00057987641139
ko04120	Ubiquitin mediated proteolysis	7/1039	138/7206	0.000816540580599
ko04610	Complement and coagulation cascades	2/1039	79/7206	0.000978924375847
ko03008	Ribosome biogenesis in eukaryotes	2/1039	79/7206	0.000978924375847
ko04912	GnRH signaling pathway	31/1039	122/7206	0.00107593697285
ko04932	Non-alcoholic fatty liver disease (NAFLD)	12/1039	182/7206	0.00126374031402
ko05414	Dilated cardiomyopathy	29/1039	112/7206	0.00153927952213
ko04064	NF-kappa B signaling pathway	4/1039	96/7206	0.00188807045452
ko04626	Plant-pathogen interaction	8/1039	18/7206	0.00207072088839
ko00310	Lysine degradation	2/1039	73/7206	0.00207486617015
ko00480	Glutathione metabolism	1/1039	55/7206	0.00325376352849
ko00590	Arachidonic acid metabolism	1/1039	52/7206	0.00485053221682
ko01524	Platinum drug resistance	3/1039	76/7206	0.00493519044614
ko04014	Ras signaling pathway	57/1039	279/7206	0.00524167492601
ko04657	IL-17 signaling pathway	4/1039	87/7206	0.00530333705658
ko05222	Small cell lung cancer	4/1039	89/7206	0.00552378295777
ko04371	Apelin signaling pathway	39/1039	177/7206	0.00636549664747
ko05140	Leishmaniasis	3/1039	75/7206	0.00722654203285
ko05161	Hepatitis B	13/1039	173/7206	0.00811105511975
ko05166	HTLV-I infection	27/1039	292/7206	0.00831887457119
ko00562	Inositol phosphate metabolism	22/1039	89/7206	0.00910617406339
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1039	14/7206	0.0094370333636
ko04330	Notch signaling pathway	2/1039	62/7206	0.00951338168206
ko04350	TGF-beta signaling pathway	6/1039	103/7206	0.010244678467
ko03420	Nucleotide excision repair	1/1039	46/7206	0.0107514396868
ko04630	Jak-STAT signaling pathway	9/1039	132/7206	0.0116491641739
ko05231	Choline metabolism in cancer	30/1039	134/7206	0.0123890078581
ko00240	Pyrimidine metabolism	7/1039	110/7206	0.0131234394201
ko05205	Proteoglycans in cancer	25/1039	271/7206	0.0132273630029
ko04550	Signaling pathways regulating pluripotency of stem cells	13/1039	165/7206	0.0133190647236
ko05215	Prostate cancer	7/1039	111/7206	0.0133406421065
ko05217	Basal cell carcinoma	3/1039	68/7206	0.014202103789
ko05034	Alcoholism	48/1039	238/7206	0.0143002460877
ko04146	Peroxisome	5/1039	89/7206	0.0143399872574
ko05145	Toxoplasmosis	9/1039	126/7206	0.0150080123929
ko05418	Fluid shear stress and atherosclerosis	14/1039	173/7206	0.0154428198327
ko03022	Basal transcription factors	1/1039	44/7206	0.0161003760084
ko05144	Malaria	1/1039	45/7206	0.016633317544
ko00071	Fatty acid degradation	1/1039	45/7206	0.016633317544
ko05016	Huntington's disease	19/1039	215/7206	0.017559795219
ko04210	Apoptosis	15/1039	180/7206	0.0175941940237
ko04062	Chemokine signaling pathway	41/1039	201/7206	0.0187494084613
ko04510	Focal adhesion	22/1039	240/7206	0.0190030824031
ko05321	Inflammatory bowel disease (IBD)	2/1039	56/7206	0.0196357059094
ko04114	Oocyte meiosis	30/1039	139/7206	0.0200075042606
ko05202	Transcriptional misregulation in cancer	16/1039	188/7206	0.0200236127597
ko05410	Hypertrophic cardiomyopathy (HCM)	23/1039	100/7206	0.0206865418138
ko04922	Glucagon signaling pathway	28/1039	128/7206	0.0214794320955
ko05214	Glioma	19/1039	79/7206	0.0225307905742
ko05200	Pathways in cancer	54/1039	492/7206	0.0236891253349
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1039	40/7206	0.0237032858605
ko04961	Endocrine and other factor-regulated calcium reabsorption	15/1039	59/7206	0.02372860691
ko04976	Bile secretion	19/1039	80/7206	0.0238639943588
ko05131	Shigellosis	5/1039	82/7206	0.0266624054054
ko03018	RNA degradation	5/1039	84/7206	0.0271563936235
ko04214	Apoptosis - fly	4/1039	72/7206	0.0277690536822
ko04622	RIG-I-like receptor signaling pathway	3/1039	62/7206	0.0281570378573
ko04964	Proximal tubule bicarbonate reclamation	9/1039	29/7206	0.0282027403617
ko04115	p53 signaling pathway	4/1039	74/7206	0.0286160265155
ko04918	Thyroid hormone synthesis	20/1039	86/7206	0.0289053894473
ko00982	Drug metabolism - cytochrome P450	1/1039	37/7206	0.0350945480464
ko03410	Base excision repair	1/1039	38/7206	0.0351581813171
ko05133	Pertussis	6/1039	87/7206	0.0450647248588
ko04142	Lysosome	13/1039	151/7206	0.0454880351084
ko04710	Circadian rhythm	11/1039	43/7206	0.047670880444
ko05224	Breast cancer	16/1039	174/7206	0.0487851811401