ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 95/656 423/7206 1.00738157505e-17 ko05033 Nicotine addiction 28/656 56/7206 2.73506061297e-15 ko04724 Glutamatergic synapse 46/656 152/7206 5.95266665768e-14 ko04721 Synaptic vesicle cycle 32/656 80/7206 7.81181645739e-14 ko04728 Dopaminergic synapse 47/656 185/7206 3.40303757128e-11 ko04713 Circadian entrainment 38/656 136/7206 1.38543560287e-10 ko04727 GABAergic synapse 33/656 110/7206 3.02441605509e-10 ko05032 Morphine addiction 30/656 110/7206 2.32086393945e-08 ko04966 Collecting duct acid secretion 13/656 26/7206 8.94048697797e-08 ko04723 Retrograde endocannabinoid signaling 39/656 175/7206 1.30029015143e-07 ko04970 Salivary secretion 26/656 95/7206 1.87184397941e-07 ko04911 Insulin secretion 29/656 117/7206 3.79494330065e-07 ko04514 Cell adhesion molecules (CAMs) 31/656 130/7206 3.81370335063e-07 ko04725 Cholinergic synapse 35/656 160/7206 8.3031948078e-07 ko05031 Amphetamine addiction 24/656 91/7206 1.16021999999e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 21/656 74/7206 1.48615575429e-06 ko05203 Viral carcinogenesis 6/656 277/7206 3.26524361568e-06 ko04024 cAMP signaling pathway 49/656 279/7206 5.72193435326e-06 ko04512 ECM-receptor interaction 20/656 79/7206 1.75255758887e-05 ko05030 Cocaine addiction 19/656 73/7206 1.85364814534e-05 ko04964 Proximal tubule bicarbonate reclamation 11/656 29/7206 2.45446129551e-05 ko04974 Protein digestion and absorption 22/656 96/7206 3.65096777826e-05 ko04120 Ubiquitin mediated proteolysis 1/656 138/7206 3.85259949147e-05 ko04261 Adrenergic signaling in cardiomyocytes 36/656 205/7206 0.000103498794835 ko04726 Serotonergic synapse 27/656 137/7206 0.000113513664105 ko04010 MAPK signaling pathway 50/656 321/7206 0.000137939643063 ko05322 Systemic lupus erythematosus 2/656 151/7206 0.000140922741666 ko04060 Cytokine-cytokine receptor interaction 4/656 191/7206 0.000165518699939 ko05166 HTLV-I infection 10/656 292/7206 0.000167375379293 ko05164 Influenza A 3/656 167/7206 0.000183598882833 ko04211 Longevity regulating pathway 1/656 123/7206 0.000189948187575 ko03040 Spliceosome 2/656 145/7206 0.000198288354847 ko04744 Phototransduction 11/656 36/7206 0.000235668612862 ko05168 Herpes simplex infection 4/656 182/7206 0.000333462422813 ko04360 Axon guidance 38/656 233/7206 0.000430879660301 ko04720 Long-term potentiation 20/656 99/7206 0.000570100561906 ko04978 Mineral absorption 11/656 40/7206 0.000647242361854 ko04140 Autophagy - animal 4/656 164/7206 0.000890642734395 ko01200 Carbon metabolism 2/656 128/7206 0.000892488037002 ko03013 RNA transport 4/656 166/7206 0.000895917320431 ko04932 Non-alcoholic fatty liver disease (NAFLD) 5/656 182/7206 0.000977827499891 ko04972 Pancreatic secretion 21/656 111/7206 0.0011847849571 ko05110 Vibrio cholerae infection 14/656 63/7206 0.0012934145101 ko04020 Calcium signaling pathway 40/656 265/7206 0.00143791702741 ko05120 Epithelial cell signaling in Helicobacter pylori infection 18/656 92/7206 0.00152351101904 ko04621 NOD-like receptor signaling pathway 4/656 157/7206 0.00176804512548 ko05161 Hepatitis B 5/656 173/7206 0.00188505155687 ko04924 Renin secretion 17/656 86/7206 0.00190836442949 ko04145 Phagosome 27/656 162/7206 0.00202278854445 ko04151 PI3K-Akt signaling pathway 53/656 390/7206 0.00268447922321 ko04742 Taste transduction 13/656 61/7206 0.00283331143453 ko04540 Gap junction 22/656 128/7206 0.00295425748065 ko04630 Jak-STAT signaling pathway 3/656 132/7206 0.00318857220006 ko05016 Huntington's disease 8/656 215/7206 0.00354599802641 ko04971 Gastric acid secretion 18/656 98/7206 0.00376847549248 ko04014 Ras signaling pathway 40/656 279/7206 0.00386877326415 ko04730 Long-term depression 15/656 78/7206 0.00455576711029 ko04022 cGMP-PKG signaling pathway 32/656 216/7206 0.00538405490901 ko04914 Progesterone-mediated oocyte maturation 2/656 104/7206 0.00541004862544 ko04976 Bile secretion 15/656 80/7206 0.0055820953866 ko00430 Taurine and hypotaurine metabolism 5/656 14/7206 0.00614133647373 ko00564 Glycerophospholipid metabolism 2/656 99/7206 0.00772624901681 ko04612 Antigen processing and presentation 1/656 77/7206 0.00894555768843 ko03008 Ribosome biogenesis in eukaryotes 1/656 79/7206 0.00911174704477 ko04064 NF-kappa B signaling pathway 2/656 96/7206 0.0111591740716 ko04611 Platelet activation 6/656 163/7206 0.0123472572256 ko04214 Apoptosis - fly 1/656 72/7206 0.0130985914819 ko04950 Maturity onset diabetes of the young 7/656 29/7206 0.0132416733377 ko05169 Epstein-Barr virus infection 9/656 206/7206 0.0135114241094 ko01524 Platinum drug resistance 1/656 76/7206 0.0138006939796 ko04740 Olfactory transduction 14/656 80/7206 0.0165603225909 ko04015 Rap1 signaling pathway 37/656 278/7206 0.0186663384332 ko04745 Phototransduction - fly 8/656 38/7206 0.0189621142115 ko04141 Protein processing in endoplasmic reticulum 8/656 184/7206 0.0191051673708 ko04961 Endocrine and other factor-regulated calcium reabsorption 11/656 59/7206 0.0195454979828 ko04921 Oxytocin signaling pathway 29/656 209/7206 0.0198886487392 ko05220 Chronic myeloid leukemia 2/656 85/7206 0.0222721363361 ko04213 Longevity regulating pathway - multiple species 2/656 86/7206 0.0223365350674 ko04146 Peroxisome 2/656 89/7206 0.0234701623647 ko04668 TNF signaling pathway 4/656 120/7206 0.0237855029745 ko00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 6/656 26/7206 0.0263809433893 ko04137 Mitophagy - animal 2/656 82/7206 0.0317462963728 ko00604 Glycosphingolipid biosynthesis - ganglio series 4/656 14/7206 0.0325208175894 ko03018 RNA degradation 2/656 84/7206 0.0327955081105 ko05323 Rheumatoid arthritis 14/656 89/7206 0.0391109882933 ko04110 Cell cycle 6/656 145/7206 0.0393828495809 ko00330 Arginine and proline metabolism 1/656 61/7206 0.0410008253101 ko02024 Quorum sensing 4/656 15/7206 0.0412437322668 ko04913 Ovarian steroidogenesis 1/656 63/7206 0.0429249518721 ko05215 Prostate cancer 4/656 111/7206 0.0440915656524 ko04210 Apoptosis 9/656 180/7206 0.0493619182722