ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	188/1113	423/7206	3.01104998413e-49
ko04724	Glutamatergic synapse	87/1113	152/7206	4.71943878528e-33
ko05033	Nicotine addiction	46/1113	56/7206	1.60158982569e-28
ko05032	Morphine addiction	63/1113	110/7206	3.38041522575e-24
ko04728	Dopaminergic synapse	85/1113	185/7206	2.01061618544e-23
ko04713	Circadian entrainment	70/1113	136/7206	4.70556674845e-23
ko04727	GABAergic synapse	61/1113	110/7206	1.8770162903e-22
ko04725	Cholinergic synapse	76/1113	160/7206	3.80720090575e-22
ko04721	Synaptic vesicle cycle	47/1113	80/7206	5.67200719556e-19
ko04723	Retrograde endocannabinoid signaling	74/1113	175/7206	5.87346477532e-18
ko04020	Calcium signaling pathway	94/1113	265/7206	2.41555308964e-16
ko04726	Serotonergic synapse	60/1113	137/7206	1.24534271487e-15
ko04024	cAMP signaling pathway	96/1113	279/7206	1.59360238625e-15
ko04911	Insulin secretion	52/1113	117/7206	4.99666453149e-14
ko04921	Oxytocin signaling pathway	76/1113	209/7206	5.53900319622e-14
ko04742	Taste transduction	34/1113	61/7206	3.78527100942e-13
ko05031	Amphetamine addiction	43/1113	91/7206	6.016597194e-13
ko04744	Phototransduction	23/1113	36/7206	5.44296554797e-11
ko04720	Long-term potentiation	42/1113	99/7206	8.81503104962e-11
ko04261	Adrenergic signaling in cardiomyocytes	64/1113	205/7206	1.01638143038e-08
ko03040	Spliceosome	2/1113	145/7206	1.66100083429e-08
ko03010	Ribosome	1/1113	129/7206	1.82058031283e-08
ko04970	Salivary secretion	37/1113	95/7206	1.94325255713e-08
ko04925	Aldosterone synthesis and secretion	38/1113	105/7206	1.44425199646e-07
ko05030	Cocaine addiction	29/1113	73/7206	4.06946074338e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1113	74/7206	5.71977340437e-07
ko04971	Gastric acid secretion	35/1113	98/7206	6.3070895639e-07
ko05168	Herpes simplex infection	7/1113	182/7206	6.97157323285e-07
ko04966	Collecting duct acid secretion	15/1113	26/7206	8.89956861588e-07
ko05322	Systemic lupus erythematosus	5/1113	151/7206	2.02966113389e-06
ko03013	RNA transport	7/1113	166/7206	6.09076320035e-06
ko04070	Phosphatidylinositol signaling system	36/1113	112/7206	8.10130681681e-06
ko04730	Long-term depression	28/1113	78/7206	8.7121982209e-06
ko04010	MAPK signaling pathway	79/1113	321/7206	1.19460695095e-05
ko05203	Viral carcinogenesis	19/1113	277/7206	1.34704560067e-05
ko04745	Phototransduction - fly	17/1113	38/7206	1.63154316043e-05
ko05164	Influenza A	8/1113	167/7206	1.93811009295e-05
ko04360	Axon guidance	60/1113	233/7206	4.15226559308e-05
ko04060	Cytokine-cytokine receptor interaction	11/1113	191/7206	4.22910473054e-05
ko04022	cGMP-PKG signaling pathway	56/1113	216/7206	5.07655061837e-05
ko04612	Antigen processing and presentation	1/1113	77/7206	5.09383615068e-05
ko04924	Renin secretion	28/1113	86/7206	6.21625911233e-05
ko04514	Cell adhesion molecules (CAMs)	38/1113	130/7206	6.45594718346e-05
ko04110	Cell cycle	7/1113	145/7206	0.000101249432277
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1113	79/7206	0.000105688775855
ko04141	Protein processing in endoplasmic reticulum	11/1113	184/7206	0.000110706146901
ko04740	Olfactory transduction	26/1113	80/7206	0.000123518318041
ko05110	Vibrio cholerae infection	22/1113	63/7206	0.000129055648098
ko04972	Pancreatic secretion	33/1113	111/7206	0.000154697695914
ko04120	Ubiquitin mediated proteolysis	7/1113	138/7206	0.000196920208297
ko04014	Ras signaling pathway	66/1113	279/7206	0.000255180301622
ko04621	NOD-like receptor signaling pathway	9/1113	157/7206	0.000296386579464
ko04750	Inflammatory mediator regulation of TRP channels	34/1113	122/7206	0.000355388887548
ko03008	Ribosome biogenesis in eukaryotes	2/1113	79/7206	0.000417447164272
ko04072	Phospholipase D signaling pathway	49/1113	197/7206	0.000436919296471
ko05162	Measles	6/1113	120/7206	0.000514954575776
ko04964	Proximal tubule bicarbonate reclamation	12/1113	29/7206	0.000697859680104
ko04260	Cardiac muscle contraction	28/1113	98/7206	0.00097959155371
ko04540	Gap junction	34/1113	128/7206	0.00115518088701
ko05169	Epstein-Barr virus infection	16/1113	206/7206	0.00117211795833
ko05166	HTLV-I infection	26/1113	292/7206	0.00119018245584
ko04710	Circadian rhythm	15/1113	43/7206	0.00202754493337
ko05414	Dilated cardiomyopathy	30/1113	112/7206	0.00211960687017
ko05161	Hepatitis B	13/1113	173/7206	0.00264995823896
ko05205	Proteoglycans in cancer	25/1113	271/7206	0.00267082327608
ko04626	Plant-pathogen interaction	8/1113	18/7206	0.00324477313969
ko05140	Leishmaniasis	3/1113	75/7206	0.0033165517919
ko04330	Notch signaling pathway	2/1113	62/7206	0.00409105732996
ko04976	Bile secretion	22/1113	80/7206	0.00478909305729
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1113	100/7206	0.00518745639705
ko04371	Apelin signaling pathway	41/1113	177/7206	0.00596688236062
ko04915	Estrogen signaling pathway	32/1113	131/7206	0.00682537141231
ko03420	Nucleotide excision repair	1/1113	46/7206	0.00691085506841
ko04610	Complement and coagulation cascades	4/1113	79/7206	0.00714587527325
ko04930	Type II diabetes mellitus	16/1113	54/7206	0.00721908352795
ko04922	Glucagon signaling pathway	31/1113	128/7206	0.00901345633659
ko04064	NF-kappa B signaling pathway	6/1113	96/7206	0.00980270771774
ko04630	Jak-STAT signaling pathway	10/1113	132/7206	0.0101450187092
ko03022	Basal transcription factors	1/1113	44/7206	0.0104547702127
ko00071	Fatty acid degradation	1/1113	45/7206	0.0109234671494
ko00280	Valine, leucine and isoleucine degradation	2/1113	54/7206	0.0126596959244
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1113	14/7206	0.0131936070967
ko05131	Shigellosis	5/1113	82/7206	0.0137739709722
ko05016	Huntington's disease	21/1113	215/7206	0.0166191020893
ko05145	Toxoplasmosis	10/1113	126/7206	0.0174615839173
ko04146	Peroxisome	6/1113	89/7206	0.0179985825467
ko00590	Arachidonic acid metabolism	2/1113	52/7206	0.0187187775642
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1113	92/7206	0.0188766061694
ko04622	RIG-I-like receptor signaling pathway	3/1113	62/7206	0.0199048423737
ko04657	IL-17 signaling pathway	6/1113	87/7206	0.0243664699933
ko05133	Pertussis	6/1113	87/7206	0.0243664699933
ko05219	Bladder cancer	2/1113	48/7206	0.0262284360107
ko04960	Aldosterone-regulated sodium reabsorption	12/1113	41/7206	0.0265556442592
ko05206	MicroRNAs in cancer	17/1113	177/7206	0.0269734606291
ko04350	TGF-beta signaling pathway	8/1113	103/7206	0.0275583256506
ko04510	Focal adhesion	25/1113	240/7206	0.0288486544624
ko04973	Carbohydrate digestion and absorption	12/1113	42/7206	0.0291294085255
ko04114	Oocyte meiosis	31/1113	139/7206	0.0319848404448
ko03018	RNA degradation	6/1113	84/7206	0.032752044327
ko00500	Starch and sucrose metabolism	1/1113	35/7206	0.0339803882999
ko04115	p53 signaling pathway	5/1113	74/7206	0.0351278439489
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1113	182/7206	0.0371703582146
ko05144	Malaria	2/1113	45/7206	0.0376523378155
ko00562	Inositol phosphate metabolism	21/1113	89/7206	0.0384036753911
ko05321	Inflammatory bowel disease (IBD)	3/1113	56/7206	0.0388586912484
ko04962	Vasopressin-regulated water reabsorption	15/1113	58/7206	0.0419759359996
ko04270	Vascular smooth muscle contraction	33/1113	154/7206	0.0423675979921
ko04912	GnRH signaling pathway	27/1113	122/7206	0.0433974783811
ko04961	Endocrine and other factor-regulated calcium reabsorption	15/1113	59/7206	0.0445050688127
ko05034	Alcoholism	48/1113	238/7206	0.0446439386904
ko04217	Necroptosis	18/1113	178/7206	0.0458926696304
ko04214	Apoptosis - fly	5/1113	72/7206	0.0478087226432