ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	191/1191	423/7206	1.47043114124e-46
ko04724	Glutamatergic synapse	94/1191	152/7206	4.60374676324e-37
ko05032	Morphine addiction	73/1191	110/7206	6.5740191946e-32
ko04713	Circadian entrainment	82/1191	136/7206	2.81445966144e-31
ko05033	Nicotine addiction	48/1191	56/7206	4.86383896864e-30
ko04727	GABAergic synapse	69/1191	110/7206	5.82367750911e-28
ko04728	Dopaminergic synapse	93/1191	185/7206	5.6041697552e-27
ko04725	Cholinergic synapse	81/1191	160/7206	7.27128458917e-24
ko04723	Retrograde endocannabinoid signaling	81/1191	175/7206	1.13499766862e-20
ko04721	Synaptic vesicle cycle	50/1191	80/7206	1.83264429099e-20
ko04024	cAMP signaling pathway	109/1191	279/7206	3.11370777931e-20
ko04911	Insulin secretion	60/1191	117/7206	2.60039266171e-18
ko04726	Serotonergic synapse	66/1191	137/7206	3.5542918955e-18
ko04921	Oxytocin signaling pathway	84/1191	209/7206	1.2808544121e-16
ko04020	Calcium signaling pathway	98/1191	265/7206	2.2569791998e-16
ko04742	Taste transduction	37/1191	61/7206	7.347789083e-15
ko05031	Amphetamine addiction	47/1191	91/7206	9.13554501577e-15
ko04720	Long-term potentiation	49/1191	99/7206	2.15836023758e-14
ko04261	Adrenergic signaling in cardiomyocytes	78/1191	205/7206	5.03436863082e-14
ko04744	Phototransduction	26/1191	36/7206	1.74452988233e-13
ko04925	Aldosterone synthesis and secretion	46/1191	105/7206	3.18466374476e-11
ko04970	Salivary secretion	43/1191	95/7206	3.81409833094e-11
ko03040	Spliceosome	1/1191	145/7206	1.96545432153e-10
ko04971	Gastric acid secretion	42/1191	98/7206	5.35144023696e-10
ko05030	Cocaine addiction	33/1191	73/7206	7.61073990641e-09
ko04740	Olfactory transduction	35/1191	80/7206	7.73247575443e-09
ko04070	Phosphatidylinositol signaling system	43/1191	112/7206	2.03272300385e-08
ko04010	MAPK signaling pathway	91/1191	321/7206	5.23634828745e-08
ko04022	cGMP-PKG signaling pathway	66/1191	216/7206	2.00510846545e-07
ko04360	Axon guidance	69/1191	233/7206	3.73766281024e-07
ko05322	Systemic lupus erythematosus	5/1191	151/7206	6.03040468838e-07
ko04060	Cytokine-cytokine receptor interaction	9/1191	191/7206	8.42400378111e-07
ko03013	RNA transport	7/1191	166/7206	1.27095427815e-06
ko04745	Phototransduction - fly	19/1191	38/7206	1.8124707203e-06
ko04072	Phospholipase D signaling pathway	59/1191	197/7206	2.11142157348e-06
ko05168	Herpes simplex infection	9/1191	182/7206	2.33977118461e-06
ko04730	Long-term depression	30/1191	78/7206	3.26146538195e-06
ko04972	Pancreatic secretion	38/1191	111/7206	4.023253738e-06
ko04540	Gap junction	42/1191	128/7206	5.395745878e-06
ko04961	Endocrine and other factor-regulated calcium reabsorption	24/1191	59/7206	8.319775941e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1191	74/7206	9.42139072256e-06
ko04014	Ras signaling pathway	74/1191	279/7206	1.62504098851e-05
ko04141	Protein processing in endoplasmic reticulum	11/1191	184/7206	1.99658199274e-05
ko04110	Cell cycle	7/1191	145/7206	2.25361151922e-05
ko05203	Viral carcinogenesis	22/1191	277/7206	3.21670362836e-05
ko04915	Estrogen signaling pathway	40/1191	131/7206	6.66530019576e-05
ko04621	NOD-like receptor signaling pathway	9/1191	157/7206	7.31917267613e-05
ko04924	Renin secretion	29/1191	86/7206	9.54365983841e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1191	79/7206	0.00010317036725
ko05110	Vibrio cholerae infection	23/1191	63/7206	0.000108044302698
ko04750	Inflammatory mediator regulation of TRP channels	37/1191	122/7206	0.000117392869315
ko04612	Antigen processing and presentation	2/1191	77/7206	0.00016859722363
ko04610	Complement and coagulation cascades	2/1191	79/7206	0.00017522279534
ko03008	Ribosome biogenesis in eukaryotes	2/1191	79/7206	0.00017522279534
ko04976	Bile secretion	27/1191	80/7206	0.000188970008312
ko05164	Influenza A	11/1191	167/7206	0.000191409190189
ko05414	Dilated cardiomyopathy	34/1191	112/7206	0.000260428002534
ko04371	Apelin signaling pathway	48/1191	177/7206	0.000299894007282
ko04912	GnRH signaling pathway	36/1191	122/7206	0.000301922023594
ko04966	Collecting duct acid secretion	12/1191	26/7206	0.000392019691027
ko04260	Cardiac muscle contraction	30/1191	98/7206	0.000497465565663
ko04514	Cell adhesion molecules (CAMs)	37/1191	130/7206	0.0005039186174
ko05162	Measles	7/1191	120/7206	0.00070227611044
ko04146	Peroxisome	4/1191	89/7206	0.000816881935363
ko04626	Plant-pathogen interaction	9/1191	18/7206	0.00104547814143
ko04064	NF-kappa B signaling pathway	5/1191	96/7206	0.00127272632042
ko04120	Ubiquitin mediated proteolysis	10/1191	138/7206	0.00168364700656
ko00590	Arachidonic acid metabolism	1/1191	52/7206	0.00204310451239
ko05231	Choline metabolism in cancer	36/1191	134/7206	0.00211228822512
ko00240	Pyrimidine metabolism	7/1191	110/7206	0.00260776378327
ko04923	Regulation of lipolysis in adipocytes	23/1191	77/7206	0.00304989898329
ko04922	Glucagon signaling pathway	34/1191	128/7206	0.0036683958014
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1191	14/7206	0.00387620572481
ko00071	Fatty acid degradation	1/1191	45/7206	0.00438110001141
ko03420	Nucleotide excision repair	1/1191	46/7206	0.00441309540192
ko05205	Proteoglycans in cancer	28/1191	271/7206	0.00443569608773
ko04015	Rap1 signaling pathway	64/1191	278/7206	0.00493273205827
ko05016	Huntington's disease	21/1191	215/7206	0.00508478695905
ko00480	Glutathione metabolism	2/1191	55/7206	0.00563786874931
ko05169	Epstein-Barr virus infection	20/1191	206/7206	0.00570066408063
ko04270	Vascular smooth muscle contraction	39/1191	154/7206	0.00574039649647
ko05321	Inflammatory bowel disease (IBD)	2/1191	56/7206	0.00576491134678
ko00562	Inositol phosphate metabolism	25/1191	89/7206	0.00578476538085
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1191	182/7206	0.00623669167495
ko04640	Hematopoietic cell lineage	3/1191	64/7206	0.00639628395652
ko04062	Chemokine signaling pathway	48/1191	201/7206	0.00673044850224
ko03022	Basal transcription factors	1/1191	44/7206	0.00674872781112
ko05140	Leishmaniasis	4/1191	75/7206	0.00701471597172
ko05034	Alcoholism	55/1191	238/7206	0.00755992325641
ko04918	Thyroid hormone synthesis	24/1191	86/7206	0.00780132487324
ko04114	Oocyte meiosis	35/1191	139/7206	0.00780652006605
ko04630	Jak-STAT signaling pathway	11/1191	132/7206	0.00885265184985
ko00330	Arginine and proline metabolism	3/1191	61/7206	0.00917788701093
ko04622	RIG-I-like receptor signaling pathway	3/1191	62/7206	0.00918798790966
ko05214	Glioma	22/1191	79/7206	0.00942287036384
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1191	40/7206	0.00987080584927
ko00140	Steroid hormone biosynthesis	1/1191	41/7206	0.00994689295069
ko04710	Circadian rhythm	14/1191	43/7206	0.0112075554044
ko04916	Melanogenesis	35/1191	142/7206	0.0117174124513
ko04711	Circadian rhythm - fly	6/1191	13/7206	0.0120823758693
ko04657	IL-17 signaling pathway	6/1191	87/7206	0.0127931252382
ko03320	PPAR signaling pathway	4/1191	69/7206	0.0135091904169
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1191	100/7206	0.0142060627429
ko04930	Type II diabetes mellitus	16/1191	54/7206	0.0153226779432
ko03018	RNA degradation	6/1191	84/7206	0.0173510325483
ko04722	Neurotrophin signaling pathway	38/1191	160/7206	0.0173942026513
ko04960	Aldosterone-regulated sodium reabsorption	13/1191	41/7206	0.0175262136513
ko00260	Glycine, serine and threonine metabolism	2/1191	48/7206	0.0176441110873
ko04115	p53 signaling pathway	5/1191	74/7206	0.0182052401231
ko00512	Mucin type O-glycan biosynthesis	10/1191	29/7206	0.0196068935657
ko04964	Proximal tubule bicarbonate reclamation	10/1191	29/7206	0.0196068935657
ko05166	HTLV-I infection	34/1191	292/7206	0.0197066449104
ko04975	Fat digestion and absorption	1/1191	35/7206	0.0220742340202
ko00982	Drug metabolism - cytochrome P450	1/1191	37/7206	0.0232120448798
ko00230	Purine metabolism	44/1191	194/7206	0.0238562182123
ko04214	Apoptosis - fly	5/1191	72/7206	0.0249397492527
ko00310	Lysine degradation	5/1191	73/7206	0.0252321217788
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1191	15/7206	0.0262334172803
ko00280	Valine, leucine and isoleucine degradation	3/1191	54/7206	0.0263084816897
ko04658	Th1 and Th2 cell differentiation	8/1191	96/7206	0.0266430727142
ko05418	Fluid shear stress and atherosclerosis	18/1191	173/7206	0.0290229278287
ko05161	Hepatitis B	18/1191	173/7206	0.0290229278287
ko05145	Toxoplasmosis	12/1191	126/7206	0.0295341770802
ko05222	Small cell lung cancer	7/1191	89/7206	0.0298271370591
ko04217	Necroptosis	19/1191	178/7206	0.03177816636
ko04350	TGF-beta signaling pathway	9/1191	103/7206	0.0318087439993
ko04210	Apoptosis	19/1191	180/7206	0.0321418710935
ko01524	Platinum drug resistance	6/1191	76/7206	0.0426293810722
ko05217	Basal cell carcinoma	5/1191	68/7206	0.0470209771384
ko05340	Primary immunodeficiency	1/1191	30/7206	0.0489249450167
ko04012	ErbB signaling pathway	26/1191	109/7206	0.0499563296139