ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 51/448 152/7206 5.60275948057e-25 ko05033 Nicotine addiction 30/448 56/7206 3.70963526827e-22 ko04080 Neuroactive ligand-receptor interaction 80/448 423/7206 1.65532682382e-20 ko04723 Retrograde endocannabinoid signaling 44/448 175/7206 2.98232714753e-16 ko04727 GABAergic synapse 33/448 110/7206 7.19730758259e-15 ko04713 Circadian entrainment 36/448 136/7206 3.10890854658e-14 ko05032 Morphine addiction 32/448 110/7206 4.92700140204e-14 ko04728 Dopaminergic synapse 42/448 185/7206 6.91588974001e-14 ko04721 Synaptic vesicle cycle 23/448 80/7206 2.5522383787e-10 ko04911 Insulin secretion 28/448 117/7206 3.25640831178e-10 ko04024 cAMP signaling pathway 45/448 279/7206 1.97784623059e-09 ko04720 Long-term potentiation 24/448 99/7206 4.68589225854e-09 ko05031 Amphetamine addiction 21/448 91/7206 1.09782509903e-07 ko04725 Cholinergic synapse 29/448 160/7206 1.31306433112e-07 ko04020 Calcium signaling pathway 40/448 265/7206 1.38779761101e-07 ko05030 Cocaine addiction 17/448 73/7206 1.57958589911e-06 ko04742 Taste transduction 15/448 61/7206 3.14982224715e-06 ko04261 Adrenergic signaling in cardiomyocytes 31/448 205/7206 4.58117420151e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 16/448 74/7206 8.97243803734e-06 ko04921 Oxytocin signaling pathway 30/448 209/7206 1.38246132734e-05 ko04726 Serotonergic synapse 22/448 137/7206 3.26102567543e-05 ko04072 Phospholipase D signaling pathway 27/448 197/7206 0.000117059516429 ko04010 MAPK signaling pathway 38/448 321/7206 0.000118940998201 ko04970 Salivary secretion 16/448 95/7206 0.000219301621141 ko04730 Long-term depression 14/448 78/7206 0.000272247070773 ko04514 Cell adhesion molecules (CAMs) 19/448 130/7206 0.000613132936762 ko00515 Mannose type O-glycan biosynthesis 7/448 25/7206 0.000616906107472 ko04925 Aldosterone synthesis and secretion 16/448 105/7206 0.000700318849968 ko05203 Viral carcinogenesis 5/448 277/7206 0.000813780781843 ko00604 Glycosphingolipid biosynthesis - ganglio series 5/448 14/7206 0.00113709922111 ko03040 Spliceosome 1/448 145/7206 0.00149331658718 ko05168 Herpes simplex infection 2/448 182/7206 0.00149731610685 ko00512 Mucin type O-glycan biosynthesis 7/448 29/7206 0.00161304735878 ko04360 Axon guidance 27/448 233/7206 0.00205273217194 ko04630 Jak-STAT signaling pathway 1/448 132/7206 0.00318944061844 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 12/448 79/7206 0.00326147267415 ko04740 Olfactory transduction 12/448 80/7206 0.00362722814316 ko04621 NOD-like receptor signaling pathway 2/448 157/7206 0.00419204125616 ko04070 Phosphatidylinositol signaling system 15/448 112/7206 0.00447415543973 ko04014 Ras signaling pathway 29/448 279/7206 0.00728334170955 ko04915 Estrogen signaling pathway 16/448 131/7206 0.00903163732521 ko04972 Pancreatic secretion 14/448 111/7206 0.00932550840784 ko04022 cGMP-PKG signaling pathway 23/448 216/7206 0.00967317211593 ko05161 Hepatitis B 3/448 173/7206 0.00968530032333 ko04140 Autophagy - animal 3/448 164/7206 0.0132301992461 ko05164 Influenza A 3/448 167/7206 0.0135781379471 ko00513 Various types of N-glycan biosynthesis 7/448 42/7206 0.0138828531641 ko00240 Pyrimidine metabolism 1/448 110/7206 0.0147479205542 ko05414 Dilated cardiomyopathy 14/448 112/7206 0.0153420119668 ko05012 Parkinson's disease 3/448 155/7206 0.0182951405452 ko04150 mTOR signaling pathway 4/448 184/7206 0.0189226941022 ko05205 Proteoglycans in cancer 8/448 271/7206 0.020312124016 ko04924 Renin secretion 11/448 86/7206 0.0208131545256 ko00562 Inositol phosphate metabolism 11/448 89/7206 0.0246111143814 ko03013 RNA transport 4/448 166/7206 0.034253443954 ko04146 Peroxisome 1/448 89/7206 0.0436566282275 ko05231 Choline metabolism in cancer 14/448 134/7206 0.0468444211537 ko05215 Prostate cancer 2/448 111/7206 0.0472405201436 ko04550 Signaling pathways regulating pluripotency of stem cells 4/448 165/7206 0.0476435436869