ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	193/1090	423/7206	2.23083100278e-54
ko04724	Glutamatergic synapse	89/1090	152/7206	1.31208582555e-35
ko05033	Nicotine addiction	48/1090	56/7206	7.1935253276e-32
ko05032	Morphine addiction	66/1090	110/7206	1.74996684373e-27
ko04713	Circadian entrainment	74/1090	136/7206	6.5370659331e-27
ko04727	GABAergic synapse	65/1090	110/7206	1.52786393083e-26
ko04728	Dopaminergic synapse	83/1090	185/7206	1.15408377593e-22
ko04725	Cholinergic synapse	75/1090	160/7206	5.37715755778e-22
ko04024	cAMP signaling pathway	105/1090	279/7206	3.90269943006e-21
ko04721	Synaptic vesicle cycle	48/1090	80/7206	2.75077160886e-20
ko04723	Retrograde endocannabinoid signaling	76/1090	175/7206	8.61028884479e-20
ko04020	Calcium signaling pathway	98/1090	265/7206	4.35797570678e-19
ko04742	Taste transduction	39/1090	61/7206	4.22736211152e-18
ko04911	Insulin secretion	56/1090	117/7206	3.19912507799e-17
ko04726	Serotonergic synapse	58/1090	137/7206	9.14926638405e-15
ko04921	Oxytocin signaling pathway	76/1090	209/7206	1.3997446377e-14
ko04261	Adrenergic signaling in cardiomyocytes	73/1090	205/7206	2.12828870357e-13
ko04744	Phototransduction	25/1090	36/7206	2.72387546564e-13
ko05031	Amphetamine addiction	42/1090	91/7206	1.47413139966e-12
ko04720	Long-term potentiation	44/1090	99/7206	2.18788953325e-12
ko04970	Salivary secretion	42/1090	95/7206	8.6423744768e-12
ko03040	Spliceosome	1/1090	145/7206	2.29612940707e-09
ko04740	Olfactory transduction	34/1090	80/7206	3.02692218069e-09
ko04925	Aldosterone synthesis and secretion	40/1090	105/7206	5.89849824344e-09
ko04971	Gastric acid secretion	38/1090	98/7206	7.9963941493e-09
ko05030	Cocaine addiction	31/1090	73/7206	1.54623139026e-08
ko04022	cGMP-PKG signaling pathway	65/1090	216/7206	1.89901619472e-08
ko05203	Viral carcinogenesis	13/1090	277/7206	4.38712573254e-08
ko05168	Herpes simplex infection	6/1090	182/7206	2.84192996313e-07
ko04060	Cytokine-cytokine receptor interaction	7/1090	191/7206	3.49945190675e-07
ko04966	Collecting duct acid secretion	15/1090	26/7206	6.74577271526e-07
ko04360	Axon guidance	64/1090	233/7206	9.14507193791e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1090	74/7206	1.33828899383e-06
ko04972	Pancreatic secretion	37/1090	111/7206	1.35239610697e-06
ko05322	Systemic lupus erythematosus	5/1090	151/7206	3.07434290272e-06
ko04010	MAPK signaling pathway	79/1090	321/7206	4.82225916257e-06
ko05110	Vibrio cholerae infection	24/1090	63/7206	6.61347531734e-06
ko03013	RNA transport	7/1090	166/7206	9.00327434134e-06
ko04745	Phototransduction - fly	17/1090	38/7206	1.22753267224e-05
ko04730	Long-term depression	27/1090	78/7206	1.69922103973e-05
ko04072	Phospholipase D signaling pathway	52/1090	197/7206	2.98566434943e-05
ko04514	Cell adhesion molecules (CAMs)	38/1090	130/7206	3.31832023794e-05
ko04621	NOD-like receptor signaling pathway	7/1090	157/7206	3.76893431216e-05
ko05164	Influenza A	8/1090	167/7206	4.05123385448e-05
ko04070	Phosphatidylinositol signaling system	34/1090	112/7206	4.38672627641e-05
ko04924	Renin secretion	28/1090	86/7206	4.79147857052e-05
ko04610	Complement and coagulation cascades	1/1090	79/7206	5.21602360781e-05
ko04540	Gap junction	37/1090	128/7206	5.28659657055e-05
ko04141	Protein processing in endoplasmic reticulum	10/1090	184/7206	6.03622399459e-05
ko05414	Dilated cardiomyopathy	33/1090	112/7206	8.8922003601e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1090	79/7206	8.93850689938e-05
ko04120	Ubiquitin mediated proteolysis	6/1090	138/7206	9.58756913495e-05
ko04976	Bile secretion	26/1090	80/7206	9.98679739632e-05
ko04750	Inflammatory mediator regulation of TRP channels	35/1090	122/7206	0.00010318548842
ko04110	Cell cycle	7/1090	145/7206	0.000145317677187
ko04260	Cardiac muscle contraction	29/1090	98/7206	0.000284233371754
ko03008	Ribosome biogenesis in eukaryotes	2/1090	79/7206	0.00041070828684
ko04014	Ras signaling pathway	64/1090	279/7206	0.000439263689666
ko04915	Estrogen signaling pathway	35/1090	131/7206	0.000496211047877
ko04371	Apelin signaling pathway	44/1090	177/7206	0.000604842745415
ko04612	Antigen processing and presentation	2/1090	77/7206	0.000610659730607
ko05169	Epstein-Barr virus infection	15/1090	206/7206	0.00074568561119
ko05140	Leishmaniasis	2/1090	75/7206	0.000920473240992
ko05161	Hepatitis B	12/1090	173/7206	0.00121698780614
ko04064	NF-kappa B signaling pathway	4/1090	96/7206	0.00132854491477
ko04923	Regulation of lipolysis in adipocytes	22/1090	77/7206	0.00210810081603
ko04964	Proximal tubule bicarbonate reclamation	11/1090	29/7206	0.00225575699348
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1090	14/7206	0.00229500315608
ko05205	Proteoglycans in cancer	24/1090	271/7206	0.00240025760184
ko04146	Peroxisome	4/1090	89/7206	0.00258057063947
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1090	59/7206	0.00272981273719
ko05162	Measles	7/1090	120/7206	0.00280064914241
ko04626	Plant-pathogen interaction	8/1090	18/7206	0.00283370235193
ko04330	Notch signaling pathway	2/1090	62/7206	0.00413971706636
ko00310	Lysine degradation	3/1090	73/7206	0.00477526763373
ko05166	HTLV-I infection	28/1090	292/7206	0.00580587163721
ko04270	Vascular smooth muscle contraction	36/1090	154/7206	0.00607045660008
ko05016	Huntington's disease	19/1090	215/7206	0.00676845704076
ko04912	GnRH signaling pathway	30/1090	122/7206	0.00686424012731
ko00240	Pyrimidine metabolism	7/1090	110/7206	0.0069627714633
ko04214	Apoptosis - fly	3/1090	72/7206	0.00713433791134
ko04918	Thyroid hormone synthesis	22/1090	86/7206	0.00972539651985
ko04657	IL-17 signaling pathway	5/1090	87/7206	0.0101082811058
ko03022	Basal transcription factors	1/1090	44/7206	0.0104481213124
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1090	100/7206	0.0104994195596
ko04217	Necroptosis	15/1090	178/7206	0.0105896472729
ko05144	Malaria	1/1090	45/7206	0.0106189064436
ko00071	Fatty acid degradation	1/1090	45/7206	0.0106189064436
ko03420	Nucleotide excision repair	1/1090	46/7206	0.0111052406831
ko00480	Glutathione metabolism	2/1090	55/7206	0.0127855310401
ko05321	Inflammatory bowel disease (IBD)	2/1090	56/7206	0.0131701753489
ko04630	Jak-STAT signaling pathway	10/1090	132/7206	0.0135413405897
ko04658	Th1 and Th2 cell differentiation	6/1090	96/7206	0.0137537416503
ko04640	Hematopoietic cell lineage	3/1090	64/7206	0.0137938629273
ko03018	RNA degradation	5/1090	84/7206	0.0139227201281
ko04115	p53 signaling pathway	4/1090	74/7206	0.0141126677368
ko05231	Choline metabolism in cancer	31/1090	134/7206	0.0141968052577
ko04210	Apoptosis	16/1090	180/7206	0.0152902725908
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1090	182/7206	0.0154330637494
ko05215	Prostate cancer	8/1090	111/7206	0.0158644530429
ko00590	Arachidonic acid metabolism	2/1090	52/7206	0.0184246021187
ko05131	Shigellosis	5/1090	82/7206	0.0191633091159
ko04622	RIG-I-like receptor signaling pathway	3/1090	62/7206	0.0195597060837
ko00630	Glyoxylate and dicarboxylate metabolism	1/1090	38/7206	0.0231923754915
ko03410	Base excision repair	1/1090	38/7206	0.0231923754915
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1090	92/7206	0.0266379875143
ko03320	PPAR signaling pathway	4/1090	69/7206	0.0272137178916
ko04015	Rap1 signaling pathway	55/1090	278/7206	0.0324591047582
ko05133	Pertussis	6/1090	87/7206	0.0335422373086
ko04930	Type II diabetes mellitus	14/1090	54/7206	0.0346201512272
ko01524	Platinum drug resistance	5/1090	76/7206	0.03550882359
ko00562	Inositol phosphate metabolism	21/1090	89/7206	0.0355208317584
ko00260	Glycine, serine and threonine metabolism	2/1090	48/7206	0.0398362447504
ko05219	Bladder cancer	2/1090	48/7206	0.0398362447504
ko04114	Oocyte meiosis	30/1090	139/7206	0.0411452731048
ko04218	Cellular senescence	17/1090	177/7206	0.042745108091
ko05206	MicroRNAs in cancer	17/1090	177/7206	0.042745108091
ko05145	Toxoplasmosis	11/1090	126/7206	0.0441740872402
ko04922	Glucagon signaling pathway	28/1090	128/7206	0.045142618529
ko04960	Aldosterone-regulated sodium reabsorption	11/1090	41/7206	0.0468852812134
ko04142	Lysosome	14/1090	151/7206	0.0499353651567